Central serous chorioretinopathy associated with administration of sympathomimetic agents

Michael, John C.; Pak, John; Pulido, José S.; Venecia, Guillermo de

doi:10.1016/s0002-9394(03)00076-x

Cited by 80 publications

(45 citation statements)

References 5 publications

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“…Although some studies showed that considerable amounts of MDMA can reach the vitreous humor and the eye globe De Letter et al, 2000, the toxic effect of MDMA on the retina is not completely elucidated. MDMA causes retinal hemorrhage (Jacks and Hykin, 1998), impairment of retinal function (Firth, 2006) and central serous chorioretinopathy (Michael et al, 2003). In the present study, we showed that MDMA induced toxicity in cultured rat retinal neural cells in a concentration-and temperature-dependent manner.…”

Section: Discussionsupporting

confidence: 53%

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Neuropeptide Y protects retinal neural cells against cell death induced by ecstasy

et al. 2008

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Section: Discussionsupporting

confidence: 53%

“…Although MDMA was detected in significant amounts in the eye globe and vitreous humor De Letter et al, 2000, and some serious consequences to vision have been reported in MDMA users (Jacks and Hykin, 1998;Michael et al, 2003;Firth, 2006), the effect of MDMA on the retina has only been examined in one very recent study (Miranda et al, 2007).…”

mentioning

confidence: 99%

Neuropeptide Y protects retinal neural cells against cell death induced by ecstasy

et al. 2008

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“…Recent studies have indicated that the possible site of primary pathology is the choroidal vessels [2], and that the involvement of the retinal pigment epithelium may play a pathogenetic role. Risk factors including psychological stress and type-A behaviour [3], corticosteroids [4] and sympathomimetic use [5] have been reported to induce or exacerbate CSC. Patients with CSC demonstrated increased heart-rate variability as a marker of sympathetic activity compared to controls [6].…”

Section: Introductionmentioning

confidence: 99%

Obstructive sleep apnea in patients with central serous chorioretinopathy

Kloos

Laube

Thoelen

2008

Graefes Arch Clin Exp Ophthalmol

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Background Patients with central serous chorioretinopathy (CSC) show an increased sympathetic activity compared to controls. Additionally, there are several reports of increased corticosteroid and catecholamine levels in these patients. Obstructive sleep apnea syndrome (OSAS) has been shown to enhance sympathetic activity depending on severity. Respiratory disturbance increases urinary catecholamine secretion and is associated with the occurance of hypertension in a dose dependent manner. Therefore we hypothesize that OSAS may act as a risk factor for the development of CSC. Methods Patients with active CSC or with pigment epithelial disturbances after CSC were contacted to answer a questionnaire about general health, drugs and sleeping habits and to complete the Epworth Sleepiness Scale (ESS) score, a widely used subjective measure of daytime sleepiness. Patients with an ESS score of >10 were referred to our department of pulmonary medicine for evaluating of respiratory disturbance in sleep. ResultsWe identified 56 consecutive patients with angiographic criteria for acute CSC or pigment epithelial defects after CSC, seven (12.5%) of whom were excluded because of a history of systemic or topic corticosteroid use. Thirtysix (73.5%) of the remaining 49 patients returned the questionnaire. Fourteen (38.8%) had an ESS score of >10. They were referred to the Department of Pulmonary Medicine. In eight (22.2%) of these patients, a diagnosis of obstructive sleep apnea syndrome was confirmed. Conclusions We found that 22% of the patients with acute or chronic CSC in this case series also suffered from OSAS, whereas in the general population OSAS is considerably less frequently reported (2-4%). OSAS therefore may act as a risk factor for the development of CSC. However, prospective controlled data is needed to definitely evaluate the possible association between CSC and OSAS. Also the clinical course of CSC during treatment of OSAS would be of particular interest.

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“…Although the etiology of CSCR has yet to be elucidated, several predisposing factors including type-A behavior [2], psychological stress [3], pregnancy [4], Cushing's syndrome [5], and corticosteroid [6,7], and sympathomimetic [8] use have been reported to induce or exacerbate CSCR. The common associations between many of these conditions are increased corticosteroid and catecholamine levels, which, indeed are higher in CSCR patients [6,7,9,10].…”

Section: Introductionmentioning

confidence: 99%

Central serous chorioretinopathy and risk for obstructive sleep apnea

Leveque

Musch

et al. 2007

Sleep Breath

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Patients with obstructive sleep apnea (OSA), in comparison to controls, have increased levels of circulating epinephrine and norepinephrine, both of which are risk factors for the development of central serous chorioretinopathy (CSCR). The aim of this pilot study was to investigate the frequency of symptoms that suggest OSA in CSCR patients and normal controls. The Berlin Questionnaire, a validated research tool to assess risk for OSA, was administered to 29 patients who met the criteria for active, acute, non-steroid-induced CSCR and 29 controls matched for age and sex. In this retrospective case-controlled study, the main outcome measure was increased risk for OSA. The mean age of the patients was 47.8 years (range 29-72) and the mean age of controls was 47.3 years (range 25-70). Seventy-six percent (22) of both groups were men. Survey scores showed 58.6% (17) of patients with CSCR to be at an increased risk for OSA compared to 31.0% (nine) of controls. A conditional logistic regression analysis showed that the CSCR group had a higher proportion with an increased risk for OSA compared to the control group (odds ratio=3.67; 95% CI: 1.02, 13.14; P = 0.046). Patients with CSCR may be more likely than other adults to have OSA, and screening for this sleep disorder should be considered in this population. Further research is warranted to determine whether sleep apnea may contribute to the development of CSCR, and to assess whether treatment of sleep apnea might offer a new therapeutic option for some patients with CSCR.

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Central serous chorioretinopathy associated with administration of sympathomimetic agents

Cited by 80 publications

References 5 publications

Neuropeptide Y protects retinal neural cells against cell death induced by ecstasy

Neuropeptide Y protects retinal neural cells against cell death induced by ecstasy

Obstructive sleep apnea in patients with central serous chorioretinopathy

Central serous chorioretinopathy and risk for obstructive sleep apnea

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