Central serous chorioretinopathy fundus autofluorescence comparison with two different confocal scanning laser ophthalmoscopes

Nam, Ki Tae; Yun, Cheol Min; Kim, Jee Taek; Yang, Kyung Sook; Kim, Hyun Joo; Kim, Seong-Woo; Oh, Jaeryung; Huh, Kuhl

doi:10.1007/s00417-015-2958-6

Cited by 8 publications

(3 citation statements)

References 20 publications

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“…Near-infrared (NIR) OCT (787 nm) provided better visualization of the subretinal and choroidal structures than the light of the shorter red laser wavelengths used in the Optos 200TxTM imaging system (633 nm). All participants were imaged with pseudocolor, simulated white light (488-633 nm) and green light (GAF) autofluorescence (532 nm) on UWF imaging [17].…”

Section: Methodsmentioning

confidence: 99%

Hyperpigmented spots at fundus examination: a new ocular sign in Neurofibromatosis Type I

Moramarco

Mallone

Sacchetti

et al. 2021

Orphanet J Rare Dis

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Background Neurofibromatosis Type I (NF1), also termed von Recklinghausen disease, is a rare genetic disorder that is transmitted by autosomal dominant inheritance, with complete penetrance and variable expressivity. It is caused by mutation in the NF1 gene on chromosome 17 encoding for neurofibromin, a protein with oncosuppressive activity, and it is 50% sporadic or inherited. The disease is characterized by a broad spectrum of clinical manifestations, mainly involving the nervous system, the eye and skin, and a predisposition to develop multiple benign and malignant neoplasms. Ocular diagnostic hallmarks of NF1 include optic gliomas, iris Lisch nodules, orbital and eyelid neurofibromas, eyelid café-au-lait spots. Choroidal nodules and microvascular abnormalities have recently been identified as additional NF1-related ocular manifestations. The present study was designed to describe the features and clinical significance of a new sign related to the visual apparatus in NF-1, represented by hyperpigmented spots (HSs) of the fundus oculi. Results HSs were detected in 60 (24.1%) out of 249 patients with NF1, with a positive predictive value of 100% and a negative predictive value of 44.2%. None of the healthy subjects (150 subjects) showed the presence of HSs. HSs were visible under indirect ophthalmoscopy, ultra-wide field (UWF) pseudocolor imaging and red-only laser image, near-infrared reflectance (NIR)-OCT, but they were not appreciable on UWF green reflectance. The location and features of pigmentary lesions matched with the already studied NF1-related choroidal nodules. No significant difference was found between the group of patients (n = 60) with ocular HSs and the group of patients (n = 189) without ocular pigmented spots in terms of age, gender or severity grading of the disease. A statistically significant association was demonstrated between the presence of HSs and neurofibromas (p = 0.047), and between the presence of HSs and NF1-related retinal microvascular abnormalities (p = 0.017). Conclusions We described a new ocular sign represented by HSs of the fundus in NF1. The presence of HSs was not a negative prognostic factor of the disease. Following multimodal imaging, we demonstrated that HSs and choroidal nodules were consistent with the same type of lesion, and simple indirect ophthalmoscopy allowed for screening of HSs in NF1.

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Section: Methodsmentioning

confidence: 99%

Hyperpigmented spots at fundus examination: a new ocular sign in Neurofibromatosis Type I

Moramarco

Mallone

Sacchetti

et al. 2021

Orphanet J Rare Dis

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“…All participants were imaged with multicolor, simulated white light (488-633 nm) and green light (GAF) auto uorescence (532 nm) on UWF imaging [17].…”

Section: Methodsmentioning

confidence: 99%

Hyperpigmented Spots at Fundus Examination: A New Ocular Sign in Neurofibromatosis Type I

Moramarco

Mallone

Sacchetti

et al. 2020

Preprint

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Background: Neurofibromatosis Type I (NF1), also termed von Recklinghausen disease, is a rare genetic disorder that is transmitted by autosomal dominant inheritance, with complete penetrance and variable expressivity. It is caused by mutation in the NF1 gene on chromosome 17 encoding for neurofibromin, a protein with oncosuppressive activity, and it is 50 % sporadic or inherited.The disease is characterized by a broad spectrum of clinical manifestations, mainly involving the nervous system, the eye and skin, and a predisposition to develop multiple benign and malignant neoplasms. Ocular diagnostic hallmarks of NF1 include optic gliomas, iris Lisch nodules, orbital and eyelid neurofibromas, eyelid café-au-lait spots. Choroidal nodules and microvascular abnormalities have recently been identified as additional NF1-related ocular manifestations. The present study was designed to describe the features and clinical significance of a new sign related to the visual apparatus in NF-1, represented by hyperpigmented spots (HSs) of the fundus oculi.Results: HSs were detected in 60 (24.1%) out of 249 patients with NF1, with a positive predictive value of 100% and a negative predictive value of 44.2%. None of the healthy subjects showed the presence of HSs. HSs were visible under indirect ophthalmoscopy and infrared light, but not appreciable on green reflectance. The location and features of pigmentary lesions matched with the already studied NF1-related choroidal nodules. No significant difference was found between the group of patients (n=60) with ocular HSs and the group of patients (n=189) without ocular pigmented spots in terms of age, gender or severity grading of the disease. A statistically significant association was demonstrated between the presence of HSs and neurofibromas (p=0.047), and between the presence of HSs and NF1-related retinal microvascular abnormalities (p=0.017).Conclusions: we described a new ocular sign represented by HSs of the fundus in NF1. The presence of HSs was not a negative prognostic factor of the disease. Following an in-depth instrumental investigation, we demonstrated that HSs and choroidal nodules were consistent with the same type of lesion, and simple indirect ophthalmoscopy allowed for screening of HSs in NF1.

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“…1 Precise measurement of the VF is important in the disease and is usually performed using a static automated perimeter, such as the Humphrey Field Analyzer (HFA; Carl Zeiss Meditec, Dublin, CA, USA). 2,3 Recent reports have suggested that fundus autofluorescence (FAF) imaging provides an objective measurement of the accumulation of lipofuscin in the retina in various retinal diseases, including age-related macular degeneration, central serous chorioretinopathy, 4,5 and RP. 6,7 In eyes with RP, a characteristic FAF ring is often observed in the macular region, suggesting the accumulation of lipofuscin at the level of the retinal pigment epithelium.…”

mentioning

confidence: 99%

A Prediction Method of Visual Field Sensitivity Using Fundus Autofluorescence Images in Patients With Retinitis Pigmentosa

Inoue

Nakajima

Hashimoto

et al. 2020

Invest. Ophthalmol. Vis. Sci.

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The purpose of this study was to investigate the association between fundus autofluorescence (FAF) and visual field (VF) sensitivities in eyes with retinitis pigmentosa (RP). We also investigated the model we developed to predict VF sensitivity using the FAF ring and its prediction accuracy. METHODS. The training dataset consisted of 51 eyes of 28 patients, and the testing dataset consisted of 42 eyes of 25 patients with RP. VF and FAF measurements were conducted using the Humphrey Field Analyzer (HFA) 10-2 test and Optos. The HFA 10-2 test was divided into three sectors according to the association with the FAF (IN, ON, and OUT). Moreover, concentric curves were drawn at 1-degree intervals outside the FAF ring and OUT was divided into six sectors (from OUT1 to OUT6 toward the periphery). Finally, the total deviation (TD) value was predicted using age and visual acuity (VA) in the whole field, and each of the eight sectors was compared. RESULTS. The TD value decreased significantly from IN, ON, and then toward OUT6. The absolute prediction error with the FAF ring (average, 7.6 dB) was significantly smaller than that without the FAF ring (average, 8.7 dB). The absolute prediction error with the FAF ring was significantly smaller in the central areas (IN, 4.4 dB and ON, 5.3 dB) than those in the peripheral areas (OUT1-6, 6.8-9.1 dB). CONCLUSIONS. VF sensitivity decreases in association with the FAF ring. We developed a model to predict 10-2 VF sensitivity values using the FAF ring, which enabled us to predict 10-2 TD values.

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Central serous chorioretinopathy fundus autofluorescence comparison with two different confocal scanning laser ophthalmoscopes

Abstract: The two types of FAF images of CSC showed different lesion brightness before and after CSC resolution but demonstrated similar lesion composite patterns.

Cited by 8 publications

References 20 publications

Hyperpigmented spots at fundus examination: a new ocular sign in Neurofibromatosis Type I

Hyperpigmented spots at fundus examination: a new ocular sign in Neurofibromatosis Type I

Hyperpigmented Spots at Fundus Examination: A New Ocular Sign in Neurofibromatosis Type I

A Prediction Method of Visual Field Sensitivity Using Fundus Autofluorescence Images in Patients With Retinitis Pigmentosa

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