Central subfield thickness and cube average thickness as bioimaging biomarkers for ellipsoid zone disruption in diabetic retinopathy

Abstract

BackgroundTo evaluate the association of central subfield thickness (CST) and cube average thickness (CAT) with ellipsoid zone (EZ) disruption on spectral domain optical coherence tomography (SD-OCT) in patients of diabetic retinopathy (DR).MethodsCross sectional study including consecutive patients of type 2 diabetes mellitus [without DR (No DR, n = 97); non-proliferative DR (NPDR, n = 91); proliferative DR (PDR, n = 83)] and healthy controls (n = 82) was undertaken. CST and CAT values were measured using SD-OCT. Data was analyzed using Chi square test, ANOVA and multivariate analysis. Discriminant values of CST and CAT for EZ disruption were evaluated using receiver operator characteristic curve. Area under curve (AUC) was computed.ResultsMean CAT and CST values in the study subjects showed an incremental trend. Multivariate ordinal logistic regression analysis showed increase in CST (OR = 1.022, p < 0.001) and CAT (OR = 1.029, p < 0.001) as significant independent predictors of EZ disruption. Area under curve showed excellent predictive results of CST (AUC = 0. 943 ± 0.021, 95% CI, 0.902–0.984, p < 0.05) and CAT (AUC = 0.959 ± 0.012, 95% CI 0.936–0.982, p < 0.05), as bioimaging biomarkers, for EZ disruption.ConclusionIncrease in CST and CAT is associated with increased odds of EZ disruption and these macular parameters serve as bioimaging biomarkers for EZ disruption in DR.

Correlation between vitamin D serum levels and severity of diabetic retinopathy in patients with type 2 diabetes mellitus

“…11 Early change in DRIL prospectively identifies eyes with a high probability of subsequent VA improvement or decline. Disruption of the ellipsoid zone (EZ) has been found to be associated with a decrease in VA. [12][13][14][15][16][17] RPE topographic alterations have been found to be associated with a decrease in VA and EZ disruption. [18][19][20][21] The present study was undertaken to evaluate the correlation of serum vitamin D levels with central subfield thickness (CST), cube average thickness (CAT), DRIL, EZ disruptions and RPE topographic alterations, for the first time.…”

QUANTITATIVE OPTICAL COHERENCE TOMOGRAPHY REVEALS ROD PHOTORECEPTOR DEGENERATION in EARLY DIABETIC RETINOPATHY

“…Previous studies have demonstrated the close correlation between retinal vascular abnormalities and DR severity, 5,6 and quantitative vascular features of nonproliferative DR (NPDR) have been validated for computer-aided DR staging. 7,8 Recent studies have also reported early retinal neurodegeneration in DR. [9][10][11] Moreover, electrophysiologic features have provided evidence for photoreceptor changes in patients with DR, 12,13 suggesting that outer retinal alterations may be observed in optical coherence tomography (OCT).…”