Central β-adrenoceptors mediate phasic and sustained components of hemodynamic responses to acute behavioral stress

Rauls, R. A.; Tan, Yun Long; Knuepfer, Mark M.

doi:10.1016/j.brainres.2005.04.057

Cited by 6 publications

(3 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The present results are in line with our previous study showing that a supratherapeutic dose of inhaled salbutamol increases isolated quadriceps endurance without any effect on peripheral neuromuscular fatigue (assessed by evoked muscle responses during artificial muscle stimulation) both at submaximal exercise and at exhaustion (Decorte et al, 2013). Finally, based on both the results of the present study and our previous study (Decorte et al, 2013), one can speculate that the ergogenic effect of β2-agonists may underlie on mechanisms outside the muscles, within the central nervous system for instance (Elias et al, 2004;Rauls et al, 2005).…”

Section: Discussionsupporting

confidence: 78%

Impact of salbutamol on muscle metabolism assessed by ³¹P NMR spectroscopy

Decorte

Lamalle

Carlier

et al. 2014

Scandinavian Med Sci Sports

View full text Add to dashboard Cite

The potential ergogenic effects of oral salbutamol intake were demonstrated for decades but the underlying mechanisms remain to elucidate. We hypothesized that improved exercise performance after acute oral salbutamol administration is associated with changes in muscle metabolism. Twelve healthy, nonasthmatic, moderately trained, male subjects were recruited to compare in a double-blind crossover randomized study, an oral dose of salbutamol (4 mg) and a placebo. After treatment administration, subjects performed repetitive plantar flexions to exhaustion in a 3T magnet. Continuous (31) P nuclear magnetic resonance spectroscopy assessment of the calf muscles was performed at rest, during exercise, and during recovery. No significant difference between treatments was detected in metabolite concentration at rest (P > 0.05). Creatine phosphate and inorganic phosphate changes during and immediately after exercise were similar between treatments (P > 0.05). Intramuscular pH (pHi) was significantly higher at rest, at submaximal exercise but not at exhaustion with salbutamol (pHi at 50% of exercise duration, 6.8 ± 0.1/6.9 ± 0.1 for placebo and salbutamol, respectively, P < 0.05). The maximal power (28 ± 7 W/23 ± 7 W; P = 0.001) and total work (1702 ± 442 J/1381 ± 432 J; P = 0.003) performed during plantar flexions were significantly increased with salbutamol. Salbutamol induced significant improvement in calf muscle endurance with similar metabolic responses during exercise, except slight differences in pHi. Other mechanisms than changes in muscle metabolism may be responsible for the ergogenic effect of salbutamol administration.

show abstract

Section: Discussionsupporting

confidence: 78%

Impact of salbutamol on muscle metabolism assessed by ³¹P NMR spectroscopy

Decorte

Lamalle

Carlier

et al. 2014

Scandinavian Med Sci Sports

View full text Add to dashboard Cite

show abstract

“…It is well known that propranolol, a non-selective β-adrenoceptor antagonist, acts, in part, in the central nervous system as an antihypertensive agent (Scriabine et al, 1976). Furthermore, central β-adrenoceptors have been proposed to be involved in autonomic responses induced by acute stress (Koepke and DiBona, 1985;Tan et al, 2000;Rauls et al, 2005). In contrast to heat, pretreatment with sotalol, a non-selective β-adrenoceptor antagonist, effectively reduced the CRF-induced elevation of plasma noradrenaline, whereas the reagent was relatively ineffective in the CRF-induced elevation of plasma adrenaline.…”

Section: Discussionmentioning

confidence: 99%

Role of brain adrenoceptors in the corticortopin-releasing factor-induced central activation of sympatho-adrenomedullary outflow in rats

et al. 2008

View full text Add to dashboard Cite

“…Noradrenergic and adrenergic neurotransmission within the brain can modulate the cardiovascular, neuroendocrine, behavioural and metabolic responses to psychological stress (Koepke & DiBona, 1986; Pacak et al 1995; Morilak et al 2005; Rauls et al 2005; Ritter et al 2006; Rinaman, 2007). Previous work indicates that neuronal cell bodies which synthesize noradrenaline and adrenaline are found in a limited number of brain regions, all of which are involved in cardiovascular regulation.…”

Section: Introductionmentioning

confidence: 99%

Nucleus of the solitary tract catecholaminergic neurons modulate the cardiovascular response to psychological stress in rats

Daubert

McCowan

Erdös

et al. 2012

The Journal of Physiology

View full text Add to dashboard Cite

Catecholaminergic neurons within the central nervous system are an integral part of stress-related neurocircuitry, and the nucleus of the solitary tract (NTS) plays a critical role in cardiovascular regulation. We tested the hypothesis that NTS catecholaminergic neurons attenuate psychological stress-induced increases in blood pressure and promote neuroendocrine activation in response to psychological stress.Anti-dopamine-β-hydroxylase antibody conjugated to the neurotoxin saporin (DSAP) or saline vehicle was microinjected into the NTS to lesion catecholaminergic neurons in male Sprague-Dawley rats, and 17 days later the rats were subjected to 60 min of restraint stress for five consecutive days. DSAP treatment significantly enhanced the integrated increase in mean arterial pressure during restraint on the first (800 ± 128 and 1115 ± 116 mmHg (min) for saline- and DSAP-treated rats) and fifth days (655 ± 116 and 1035 ± 113 mmHg (min) for saline- and DSAP-treated rats; P<0.01 for overall effect of DSAP treatment) of restraint. In contrast, after 60 min of restraint plasma corticosterone concentration was significantly lower in DSAP-treated compared with saline-treated rats (25.9 ± 7 compared with 46.8 ± 7 μg dl(-1) for DSAP- and saline-treated rats; P <0.05). DSAP treatment also significantly reduced baseline plasma adrenaline concentration (403 ± 69 compared with 73 ± 29 pg ml(-1) for saline- and DSAP-treated rats), but did not alter the magnitude of the adrenaline response to restraint. The data suggest that NTS catecholaminergic neurons normally inhibit the arterial pressure response, but help maintain the corticosterone response to restraint stress.

show abstract

Central β-adrenoceptors mediate phasic and sustained components of hemodynamic responses to acute behavioral stress

Cited by 6 publications

References 36 publications

Impact of salbutamol on muscle metabolism assessed by ³¹P NMR spectroscopy

Impact of salbutamol on muscle metabolism assessed by ³¹P NMR spectroscopy

Role of brain adrenoceptors in the corticortopin-releasing factor-induced central activation of sympatho-adrenomedullary outflow in rats

Nucleus of the solitary tract catecholaminergic neurons modulate the cardiovascular response to psychological stress in rats

Contact Info

Product

Resources

About

Central β-adrenoceptors mediate phasic and sustained components of hemodynamic responses to acute behavioral stress

Cited by 6 publications

References 36 publications

Impact of salbutamol on muscle metabolism assessed by 31P NMR spectroscopy

Impact of salbutamol on muscle metabolism assessed by 31P NMR spectroscopy

Role of brain adrenoceptors in the corticortopin-releasing factor-induced central activation of sympatho-adrenomedullary outflow in rats

Nucleus of the solitary tract catecholaminergic neurons modulate the cardiovascular response to psychological stress in rats

Contact Info

Product

Resources

About

Impact of salbutamol on muscle metabolism assessed by ³¹P NMR spectroscopy

Impact of salbutamol on muscle metabolism assessed by ³¹P NMR spectroscopy