Centrifugal Blood Pump for Temporary Ventricular Assist Devices With Low Priming and Ceramic Bearings

Abstract

A new model of centrifugal blood pump for temporary ventricular assist devices has been developed and evaluated. The design of the device is based on centrifugal pumping principles and the usage of ceramic bearings, resulting in a pump with reduced priming (35 ± 2 mL) that can be applied for up to 30 days. Computational fluid dynamic (CFD) analysis is an efficient tool to optimize flow path geometry, maximize hydraulic performance, and minimize shear stress, consequently decreasing hemolysis. Initial studies were conducted by analyzing flow behavior with different impellers, aiming to determine the best impeller design. After CFD studies, rapid prototyping technology was used for production of pump prototypes with three different impellers. In vitro experiments were performed with those prototypes, using a mock loop system composed of Tygon tubes, oxygenator, digital flow meter, pressure monitor, electronic driver, and adjustable clamp for flow control, filled with a solution (1/3 water, 1/3 glycerin, 1/3 alcohol) simulating blood viscosity and density. Flow-versus-pressure curves were obtained for rotational speeds of 1000, 1500, 2000, 2500, and 3000 rpm. As the next step, the CFD analysis and hydrodynamic performance results will be compared with the results of flow visualization studies and hemolysis tests.

Ventricular Assist Device Research and Development in Brazil: A Long and Promising Relationship Between Medicine and Engineering

“…In this way, the device has lower risks for thrombus formation, heating, and hemolysis, thus providing assistance for up to 30 days. The results of the hydrodynamic and hemolysis performance tests with the TCSD were satisfactory for the requirements necessary for temporary circulatory assistance, obtaining high hydrodynamic performance and low hemolysis rates [ 15 ] .…”

Numerical study on the effect of different types of impeller blades in centrifugal heart assist pump

“…Verilen grafikler (32-35) incelenecek olursa çark dönme hızının artmasıyla basınç farkının da arttığı ve debinin artmasıyla da toplam basınç farkının azaldığı tespit edilmiştir. Verilen grafiklerdeki artış ve azalış eğilimleri yapılan literatür incelemeleri sonucunda uyumlu olduğu kanısına varılmıştır [9], [10], [19], [25].…”

“…Verilen grafikler (32-35) incelenecek olursa çark dönme hızının artmasıyla basınç farkının da arttığı ve debinin artmasıyla da toplam basınç farkının azaldığı tespit edilmiştir. Verilen grafiklerdeki artış ve azalış eğilimleri yapılan literatür incelemeleri sonucunda uyumlu olduğu kanısına varılmıştır [9], [10], [19], [25]. Farklı kanat tasarımlarına sahip pompaların tasarım parametreleri için toplam basınç farkları incelendiğinde eğik kanat geometrisine sahip pompanın radyal kanat geometrisine sahip pompaya göre toplam basınç farkı %2 daha fazla olduğu tespit edilmiştir.…”

Properties of a monopivot centrifugal blood pump manufactured by 3D printing

“…Gregory et al [7] manufactured a modified blood pump prototype with adjusted inlet and outlet ports using the MJ method and evaluated the pump for suitable anatomic fit through a fitting trial. Leme et al [8] produced pump prototypes with a layer thickness of 16 lm using the MJ method to develop and evaluate a new centrifugal blood pump model and performed hydraulic experiments with the obtained prototypes using a mock loop system. Thus, the use of 3D printing technology has become more widespread in the initial development of rotary blood pumps.…”