Centrifugal partition chromatographic reaction for the production of chiral amino acids

The centrifugal partition reactor, a novel intensified continuous reactor for liquid–liquid enzymatic reactions

“…In this work, it is proposed to operate this system as a two liquid phase reactor (termed Centrifugal Partition Reactor, CPR) as already proposed as a continuous reactor for catalysis [11][12] and as a chromatographic reactor for enzymatic reactions [13][14]. Indeed, in the CPC apparatus, one of the phases, containing the enzyme catalyst, can be maintained in the reactor while the other one, carrying substrates and products, is continuously fed and extracted from the system.…”

Catalysis in Multifunctional Reactors

“…liquid-liquid extraction). CPCR has been successfully applied for enzymatic reactions [150,151]. Figure 12.…”

Polyethylene glycol and solutions of polyethylene glycol as green reaction media

“…199 Chirally selective enzymatic acylase hydrolysis of N-acetyl-L-methionine into acetic acid and L-methionine was carried out in PEG-K 3 PO 4 ABS in liquid-liquid centrifugal partition chromatography (CPC), and the products and reactants were obtained separately in the same process. 200,201 Enzyme-biocatalysts are often considered to be inherently green, clean, and nontoxic as opposed to traditional catalysts, which are often toxic metal compounds. Enzymatic syntheses are capable of providing high stereo-and regio-selectivities without using chemical protection-deprotection.…”