2022
DOI: 10.15252/embr.202153805
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Centrosome linker protein C‐Nap1 maintains stem cells in mouse testes

Abstract: The centrosome linker component C-Nap1 (encoded by CEP250) anchors filaments to centrioles that provide centrosome cohesion by connecting the two centrosomes of an interphase cell into a single microtubule organizing unit. The role of the centrosome linker during development of an animal remains enigmatic. Here, we show that male CEP250 À/À mice are sterile because sperm production is abolished. Premature centrosome separation means that germ stem cells in CEP250 À/À mice fail to establish an E-cadherin polari… Show more

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Cited by 5 publications
(20 citation statements)
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“…The Seckel-like syndrome phenotype of cattle with a homozygous truncation mutation in CEP250 made it important to study the consequence of CEP250 knockout in a mammalian model organism such as mouse. Two recent studies reported [95,96]. Importantly, both manuscripts report that Cep250 KO mice have defects in centrosome cohesion in the germline and male gametogenesis [95,96].…”
Section: The Essential Role Of Centrosome Linker In Spermatogenesismentioning
confidence: 96%
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“…The Seckel-like syndrome phenotype of cattle with a homozygous truncation mutation in CEP250 made it important to study the consequence of CEP250 knockout in a mammalian model organism such as mouse. Two recent studies reported [95,96]. Importantly, both manuscripts report that Cep250 KO mice have defects in centrosome cohesion in the germline and male gametogenesis [95,96].…”
Section: The Essential Role Of Centrosome Linker In Spermatogenesismentioning
confidence: 96%
“…Histological analysis of the major tissues of Cep250 KO mice also did not detect obvious defects although this analysis may not have tracked down minor defects. However, loss of CEP250 resulted in a defect in germ stem cell (GSC) maintenance in the testis as early as P2, leading to depletion of germ cells and male infertility [95]. Dang et al [95], showed an essential role of centrosome linker in spermatogenesis by controlling spindle orientation and asymmetric centrosome inheritance via facilitating the establishment of E-cadherin-based cortical polarity during male GSC division.…”
Section: The Essential Role Of Centrosome Linker In Spermatogenesismentioning
confidence: 99%
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