Cephaloconiosis: A free radical perspective on the proposed particulate-induced etiopathogenesis of alzheimer's dementia and related disorders

Evans, Peter H.; Klinowski, Jacek; Yano, Eriko

doi:10.1016/0306-9877(91)90213-i

Cited by 21 publications

(3 citation statements)

References 124 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Also, a quantitative relationship between free radicals and atherosclerosis does not seem to have been established. This absence of a quantitative relationship also holds, for example, for the proposed relationship between free radicals and Alzheimer's Disease (see Jeandel, Nicolas, Dubois, Nabet-Belleville, Penin, & Cuny, 1989;Evans, Klinowski, & Yano, 1991;Halliwell, 1989). Distinguishing between free radicals associated with normal aging and free radicals associated with disease may be difficult; however, this seems necessary if we are to determine if free radicals are causally involved in the aging process.…”

Section: Relationship Between Aging and Diseasesmentioning

confidence: 96%

The Free Radical Theory of Aging: A Critique and Unresolved Questions

Carlson

Forbes

1992

Can. J. Aging

View full text Add to dashboard Cite

RÉSUMÉLa théorie des radicaux libres du vieillissement est très critiquée. Ce compte-rendu traite des effets biologiques des radicaux libres au cours du processus du vieillissement, de la relation entre le vieillissement et la maladie (comment ces deux concepts peuvent être affectés par les radicaux libres) et des effets des radicaux libres tout au long du cycle de vie. Cet article met en relief des aspects qui demandent une étude plus approfondie.

show abstract

Section: Relationship Between Aging and Diseasesmentioning

confidence: 96%

The Free Radical Theory of Aging: A Critique and Unresolved Questions

Carlson

Forbes

1992

Can. J. Aging

View full text Add to dashboard Cite

show abstract

“…vitamin E and selenium, may be of some value in the treatment of geriatric subjects [58]. Recent clinical studies utilizing the aluminium and iron chelating drug desferrioxamine, suggest that the resultant claimed success of the drug could be related to its capacity to counter the adverse effects of free radicals generated by an iron-dependent mechanism [59], or indeed by direct reaction with peroxynitrite [54], Although yet to be sub stantiated, the growing evidence for oxyradical-mediated cellular injury in neuronal degeneration [60] indicates that such concepts may be of value in the continuing endeavour to elucidate the pathogenesis, and hence the prevention, of Alzheimer's dementia.…”

Section: Discussionmentioning

confidence: 99%

Aluminosilicate-lnduced Free Radical Generation by Murine Brain Glial Cells in vitro: Potential Significance in the Aetiopathogenesis of Alzheimer's Dementia

Evans

Peterhans

Bürge

et al. 1992

Dement Geriatr Cogn Disord

View full text Add to dashboard Cite

While previous studies have identified aluminosilicate deposits within the senile plaque cores from subjects with Alzheimer''s dementia, their possible role in the aetiopathogenesis of the disease remains unknown. In the present in vitro chemiluminescent study, we show that cultured murine glial cells exhibit the capacity to generate free radical and related oxygen-derived metabolites when exposed to various natural and synthetic model aluminosilicate particulate samples of differing particle size, morphology and composition. These results, if applicable to the proposed analogous in vivo situation in humans, suggest that further research into the biochemical and cellular mechanisms influencing the production and modulation of tissue-injurious free radical oxygen-derived metabolites within the brain, could have significant implications in the pathogenesis, prevention and treatment of Alzheimer''s disease.

show abstract

“…These processes underlie oxidative stress, which activates microglia, at least in part, by stimulating PRRs (e.g., TLRs), resulting in phagocytosis of the toxic molecules. The result of these processes may lead to neurodegeneration [ 86 , 87 , 88 ]. Previous studies showed that murine microglial cells exposed in vitro to aluminosilicate particles stimulated the generation of free radical reactive oxygen metabolites such as hydrogen peroxide, superoxide, and hydroxyl free radicals, leading to tissue injury [ 89 , 90 ].…”

Section: Current Perspectives On the Etiopathogenesis Of Dementiamentioning

confidence: 99%

Current Perspectives and Mechanisms of Relationship between Intestinal Microbiota Dysfunction and Dementia: A Review

Welcome

2018

Dement Geriatr Cogn Disord Extra

View full text Add to dashboard Cite

Background: Accumulating data suggest a crucial role of the intestinal microbiota in the development and progression of neurodegenerative diseases. More recently, emerging reports have revealed an association between intestinal microbiota dysfunctions and dementia, a debilitating multifactorial disorder, characterized by progressive deterioration of cognition and behavior that interferes with the social and professional life of the sufferer. However, the mechanisms of this association are not fully understood. Summary: In this review, I discuss recent data that suggest mechanisms of cross-talk between intestinal microbiota dysfunction and the brain that underlie the development of dementia. Potential therapeutic options for dementia are also discussed. The pleiotropic signaling of the metabolic products of the intestinal microbiota together with their specific roles in the maintenance of both the intestinal and blood-brain barriers as well as regulation of local, distant, and circulating immunocytes, and enteric, visceral, and central neural functions are integral to a healthy gut and brain. Key Messages: Research investigating the effect of intestinal microbiota dysfunctions on brain health should focus on multiple interrelated systems involving local and central neuroendocrine, immunocyte, and neural signaling of microbial products and transmitters and neurohumoral cells that not only maintain intestinal, but also blood brain-barrier integrity. The change in intestinal microbiome/dysbiome repertoire is crucial to the development of dementia.

show abstract

Cephaloconiosis: A free radical perspective on the proposed particulate-induced etiopathogenesis of alzheimer's dementia and related disorders

Cited by 21 publications

References 124 publications

The Free Radical Theory of Aging: A Critique and Unresolved Questions

The Free Radical Theory of Aging: A Critique and Unresolved Questions

Aluminosilicate-lnduced Free Radical Generation by Murine Brain Glial Cells in vitro: Potential Significance in the Aetiopathogenesis of Alzheimer's Dementia

Current Perspectives and Mechanisms of Relationship between Intestinal Microbiota Dysfunction and Dementia: A Review

Contact Info

Product

Resources

About