Ceramic prosthesis surfaces induce an inflammatory cell response and fibrotic tissue changes

Bertrand, Jessica; Delfosse, Daniel; Mai, V; Awiszus, Friedemann; Harnisch, Karsten; Lohmann, Christoph H.

doi:10.1302/0301-620x.100b7.bjj-2017-1590.r2

Cited by 23 publications

(22 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The previously reported incidence of ceramic fracture after C-O-C THA varied between 0.26% and 13.4% [34], whereas that of squeaking ranged from 0% to 10.7% [34]. In (36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47) .961 Vertical (mm)…”

Section: Discussionmentioning

confidence: 96%

“…Ceramic hip implants have generally been considered to be inert, and they do not produce osteolysis caused by wear particles [17]. Rony et al [46] and Bertand et al [47], however, described that the generation of wear particles from C-O-C articulations may be biologically active. Bertrand et al [47] found that the fibrotic response was more pronounced in C-O-C bearings compared with the tissues obtained from metal-on-metal or ceramic-onpolyethylene pairings.…”

Section: Discussionmentioning

confidence: 99%

“…Rony et al [46] and Bertand et al [47], however, described that the generation of wear particles from C-O-C articulations may be biologically active. Bertrand et al [47] found that the fibrotic response was more pronounced in C-O-C bearings compared with the tissues obtained from metal-on-metal or ceramic-onpolyethylene pairings. Hernigou et al [48] suggested that the risk of late dislocation was less in C-O-C bearings because of increased capsular thickness.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Eighteen-Year Follow-Up Study of 2 Alternative Bearing Surfaces Used in Total Hip Arthroplasty in the Same Young Patients

Kim

Park

2020

The Journal of Arthroplasty

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Eighteen-Year Follow-Up Study of 2 Alternative Bearing Surfaces Used in Total Hip Arthroplasty in the Same Young Patients

Kim

Park

2020

The Journal of Arthroplasty

View full text Add to dashboard Cite

“…Ample evidence is available for the pathological role of polyethylene particles in the mechanisms leading to PPOL and AL [11,[29][30][31][32]. Biotribological experiments demonstrate that even hard materials like ceramics generate nano-sized debris that could induce inflammation [33].…”

Section: Stimuli Of Periprosthetic Inflammationmentioning

confidence: 99%

Periprosthetic Osteolysis: Mechanisms, Prevention and Treatment

Goodman

Gallo

2019

JCM

177

163

View full text Add to dashboard Cite

Clinical studies, as well as in vitro and in vivo experiments have demonstrated that byproducts from joint replacements induce an inflammatory reaction that can result in periprosthetic osteolysis (PPOL) and aseptic loosening (AL). Particle-stimulated macrophages and other cells release cytokines, chemokines, and other pro-inflammatory substances that perpetuate chronic inflammation, induce osteoclastic bone resorption and suppress bone formation. Differentiation, maturation, activation, and survival of osteoclasts at the bone–implant interface are under the control of the receptor activator of nuclear factor kappa-Β ligand (RANKL)-dependent pathways, and the transcription factors like nuclear factor κB (NF-κB) and activator protein-1 (AP-1). Mechanical factors such as prosthetic micromotion and oscillations in fluid pressures also contribute to PPOL. The treatment for progressive PPOL is only surgical. In order to mitigate ongoing loss of host bone, a number of non-operative approaches have been proposed. However, except for the use of bisphosphonates in selected cases, none are evidence based. To date, the most successful and effective approach to preventing PPOL is usage of wear-resistant bearing couples in combination with advanced implant designs, reducing the load of metallic and polymer particles. These innovations have significantly decreased the revision rate due to AL and PPOL in the last decade.

show abstract

“…Joints perform tens of thousands of frictional movements in their lifetime [ 4 ]. Although the wear rate of alumina ceramic has been shown to be less than 1 μm/year, the fine particles (FPs) of Al 2 O 3 are generated by continuous frictional movement, which may promote inflammation in the adjacent tissue of implant [ 2 , 3 , 5 , 6 ]. Previous studies have shown that the treatment of Al 2 O 3 FPs induced activation of human macrophages, which produced higher levels of tumor necrosis factor-α (TNF-α) [ 7 , 8 , 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Alumina Ceramic Exacerbates the Inflammatory Disease by Activation of Macrophages and T Cells

Lim

Hwang

Park

et al. 2020

IJMS

View full text Add to dashboard Cite

(1) Background: Aluminum oxide (Al2O3) ceramic is one of the materials used for artificial joints, and it has been known that their fine particles (FPs) are provided by the wear of the ceramic. Al2O3 FPs have been shown to induce macrophage activation in vitro; however, the inflammatory effect in vivo has not been studied. (2) Methods: We examined the in vivo effect of Al2O3 FPs on the innate and adaptive immune cells in the mice. (3) Results: Al2O3 FPs promoted the activation of spleen macrophages; however, conventional dendritic cells (cDCs), plasmacytoid DCs (pDCs), and natural killer (NK) cells were not activated. In addition, increases in the CD4 and CD8 T cells was induced in the spleens of the mice treated with Al2O3 FPs, which differentiated into interferon-gamma (IFN-γ)-producing helper T1 (Th1) and cytotoxic T1 (Tc1) cells. Finally, the injection of Al2O3 FPs exacerbated dextran sulfate sodium (DSS)-induced inflammation in the colon, mediated by activated and increased number of CD4 and CD8 T cells. (4) Conclusions: These data demonstrate that FPs of Al2O3 ceramic may contribute to the exacerbation of inflammatory diseases in the patients.

show abstract

Ceramic prosthesis surfaces induce an inflammatory cell response and fibrotic tissue changes

Cited by 23 publications

References 20 publications

Eighteen-Year Follow-Up Study of 2 Alternative Bearing Surfaces Used in Total Hip Arthroplasty in the Same Young Patients

Eighteen-Year Follow-Up Study of 2 Alternative Bearing Surfaces Used in Total Hip Arthroplasty in the Same Young Patients

Periprosthetic Osteolysis: Mechanisms, Prevention and Treatment

Alumina Ceramic Exacerbates the Inflammatory Disease by Activation of Macrophages and T Cells

Contact Info

Product

Resources

About