Ceramic scaffolds enriched with gentamicin loaded poly(lactide- co -glycolide) microparticles for prevention and treatment of bone tissue infections

Rumian, Łucja; Tiainen, Hanna; Cibor, Urszula; Krok-Borkowicz, Małgorzata; Brzychczy-Włoch, Monika; Haugen, Håvard Jostein; Pamuła, Elżbieta

doi:10.1016/j.msec.2016.07.065

Cited by 40 publications

(24 citation statements)

References 54 publications

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“…Polymer composites have various excellent properties, such as biodegradability and mechanical properties. [122][123][124][125][126][127][128][129][130][131] Ceramic materials, especially HA, are the main inorganic constituents of natural bone. 19 Composite materials composed of ceramic materials and polymer materials have desirable properties for the manufacturing of scaffolds for bone tissue engineering.…”

Section: Composite Biomaterials Scaffoldsmentioning

confidence: 99%

Biomaterials for bone tissue engineering scaffolds: a review

et al. 2019

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Section: Composite Biomaterials Scaffoldsmentioning

confidence: 99%

Biomaterials for bone tissue engineering scaffolds: a review

et al. 2019

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“…In our study, at the end of the experiments (28 days), the total RFP released was 82% of the loaded drug in the scaffolds. The initial burst and the subsequent long-term sustained release is applicable to bone infection-control, allowing adequate regeneration of bone while avoiding the impairment of bone repair (Gimeno et al, 2015;Rumian et al, 2016).…”

Section: Characterization Of Composite Scaffoldsmentioning

confidence: 99%

“…Bone infection resulting from implantation or orthopaedic surgery is a serious complication characterized by an inflammatory reaction and bone destruction (Arciola et al, 2012;Rumian et al, 2016). Although implant-associated infections in orthopaedics are relatively uncommon (2-5%), implant replacement and possible resulting disabilities have a high impact on the patient's quality of life and result in economic and clinical burden (Darouiche, 2004).…”

Section: Introductionmentioning

confidence: 99%

“…Oral and systemic administration of antibiotics for the prophylaxis or treatment of bone infections can be ineffective due to low delivery and permeation of antibiotics into bone and the possible presence of bacterial biofilms (Flores et al, 2016;Furustrand Tafin et al, 2015;Zhu et al, 2015). Therefore, the need for local treatments, characterized by an initial burst of antibiotics followed by a sustained release of an adequate drug dose to prevent any further infection, seems to be imperative to successfully treat these pathologies (Gimeno et al, 2015;Rumian et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

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Composite scaffold obtained by electro-hydrodynamic technique for infection prevention and treatment in bone repair

Aragón

Feoli

Irusta

et al. 2019

International Journal of Pharmaceutics

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Bone infection is a devastating condition resulting from implant or orthopaedic surgery. Therapeutic strategies are extremely complicated and may result in serious side effects or disabilities. The development of enhanced 3D scaffolds, able to promote efficient bone regeneration, combined with targeted antibiotic release to prevent bacterial colonization, is a promising tool for the successful repair of bone defects. Herein, polymeric electrospun scaffolds composed of polycaprolactone (PCL) nanofibres decorated with poly(lactic-co-glycolic acid) (PLGA) particles loaded with rifampicin were fabricated to achieve local and sustained drug release for more efficient prevention and treatment of infection. The release profile showed an initial burst of rifampicin in the first six hours, enabling complete elimination of bacteria. Sustained and long-term release was observed until the end of the experiments (28 days), facilitating a prolonged effect on the inhibition of bacterial growth, which is in agreement with the common knowledge concerning the acidic degradation of the microparticles. In addition, bactericidal effects against gram negative (Escherichia coli) and gram positive (Staphylococcus aureus) bacteria were demonstrated at concentrations of released rifampicin up to 58 ppm after 24 h, with greater efficacy against S. aureus (13 ppm vs 58 ppm for E. coli). Cell morphology and cytocompatibility studies highlighted the suitability of the fabricated scaffolds to support cell growth, as well as their promising clinical application for bone regeneration combined with prevention or treatment of bacterial infection.

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“…The fabricated system provided the required doses of gentamicin to combat the infection after implementation of the scaffold. The system was fully cytocompatible when tested against osteoblast-like cells (Rumian et al., 2016 ).…”

Section: Systems Under Investigation For the Local Delivery Of Antibiotic For Osteomyelitis Managementmentioning

confidence: 99%

Recent advances in the local antibiotics delivery systems for management of osteomyelitis

et al. 2021

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Ceramic scaffolds enriched with gentamicin loaded poly(lactide- co -glycolide) microparticles for prevention and treatment of bone tissue infections

Cited by 40 publications

References 54 publications

Biomaterials for bone tissue engineering scaffolds: a review

Biomaterials for bone tissue engineering scaffolds: a review

Composite scaffold obtained by electro-hydrodynamic technique for infection prevention and treatment in bone repair

Recent advances in the local antibiotics delivery systems for management of osteomyelitis

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