Ceramics for Osseo-Integrated Implants

Heimke, G.

doi:10.1111/j.1551-2916.1987.tb00144.x

Cited by 14 publications

(19 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the metallic category of Biomaterials, Titanium alloys are commonly used as implant material, due to high fracture strength associated with their high fracture toughness [1]. As feasible alternative to metals due to many problems associated with them, Ceramic materials are used because of their chemical composition being closer to that of hard tissues, which give rise to a better biocompatibility [2,3]. Chemical composition of the mineral bone is close to that calcium phosphates and therefore maximum attention has been given to bioceramics compounds of this family [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Study of Microstructure at Different Sintering Temperatures of Alumina Reinforced Hydroxyapatite Bioceramic Composite

Trivedi¹,

Srivastav²,

bhatnagar³

et al. 2016

IOSR

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Study of Microstructure at Different Sintering Temperatures of Alumina Reinforced Hydroxyapatite Bioceramic Composite

Trivedi¹,

Srivastav²,

bhatnagar³

et al. 2016

IOSR

View full text Add to dashboard Cite

“…The essential feature of this bonding to bone is due to the layer of tiny hydroxyapatite particles that are deposited by the body onto the implant surface that in turn initiates a continuous bond formation (Heimke, 1990). The bone that bonds to the ceramic is free of clefts or inclusions of giant cells.…”

Section: Introduction To Calcium Phosphate Ceramicsmentioning

confidence: 99%

“…Ceramic surfaces without bone contact are typically covered by a thin layer of fibroblasts, mono-or multinuclear macrophages (giant cells). The new lamellar bone has a structure of part bone and part ceramic (Heimke, 1990).…”

Section: Introduction To Calcium Phosphate Ceramicsmentioning

confidence: 99%

“…However, Heimke (1990) noted that this did not require an absence of forces. The only forces that disturb healing are the ones that cause excessive movement at the two surfaces of the fracture.…”

mentioning

confidence: 99%

“…After the soft tissue layer forms, a layer of densified bone that looks like lamella of cortical bone forms between the soft tissue and underlying bone. Clinically, this is considered a nonunion case (Heimke, 1990).…”

mentioning

confidence: 99%

See 2 more Smart Citations

Calcium phosphate ceramic composites used for orthopedic implant applications

Olson

View full text Add to dashboard Cite

Evaluation of cytocompatibility and bending modulus of nanoceramic/polymer composites

McManus

Doremus

Siegel

et al. 2004

J Biomedical Materials Res

103

View full text Add to dashboard Cite

In an attempt to simulate the microstructure and mechanical properties of natural bone, novel nanoceramic/polymer composite formulations were fabricated and characterized with respect to their cytocompatibility and mechanical properties. The bending moduli of nanocomposite samples of either poly(L-lactic acid) (PLA) or poly(methyl methacrylate) (PMMA) with 30, 40, and 50 wt % of nanophase (<100 nm) alumina, hydroxyapatite, or titania loadings were significantly (p < 0.05) greater than those of pertinent composite formulations with conventional, coarser grained ceramics. The nanocomposite bending moduli were 1-2 orders of magnitude larger than those of the homogeneous, respective polymer. For example, compared with 0.06 GPa for the 100% PLA, the bending modulus of 50/50 nanophase alumina/PLA composites was 3.5 GPa. Osteoblast adhesion on the surfaces of the nanophase alumina/PLA composites increased as a function of the nanophase ceramic content. Most importantly, osteoblast adhesion on the 50/50 nanophase alumina/PLA substrates was similar to that observed on the 100% nanophase ceramic substrates. Similar trends of osteoblast adhesion were observed on the surfaces of the nanophase titania/polymer and nanophase hydroxyapaptite/polymer composites that were tested. In contrast, fibroblast adhesion on the nanophase composites was either similar or lower than that observed on the conventional composites with either PLA or PMMA and minimum on all tested neat nanophase substrates. The calcium content in the extracellular matrix of cultured osteoblasts was also enhanced on the nanoceramic/PLA composite substrates tested as a function of the nanophase ceramic loading and duration of cell culture. The results of the present in vitro study provide evidence that nanoceramic/polymer composite formulations are promising alternatives to conventional materials because they can potentially be designed to match the chemical, structural, and mechanical properties of bone tissue in order to overcome the limitations of the biomaterials currently used as bone prostheses.

show abstract

Ceramics for Osseo-Integrated Implants

Cited by 14 publications

References 32 publications

Study of Microstructure at Different Sintering Temperatures of Alumina Reinforced Hydroxyapatite Bioceramic Composite

Study of Microstructure at Different Sintering Temperatures of Alumina Reinforced Hydroxyapatite Bioceramic Composite

Calcium phosphate ceramic composites used for orthopedic implant applications

Evaluation of cytocompatibility and bending modulus of nanoceramic/polymer composites

Contact Info

Product

Resources

About