Ceramides improve atherosclerotic cardiovascular disease risk assessment beyond standard risk factors

Serum Ceramides as Prognostic Biomarkers of Large Thrombus Burden in Patients with STEMI: A Micro-Computed Tomography Study

“…Our results are consistent with previous studies which demonstrated significant association between elevated ceramide levels and increased coronary atherosclerotic burden in STEMI patients [9,25]. Besides the proatherogenic role that ceramides may exert, studies have also documented that distinct ceramides are associated with specific plaque characteristics (plaque rupture, higher necrotic core fraction or higher lipid core burden) or increased cardiovascular and cerebrovascular risk [26][27][28].…”

“…Ceramides constitute members of the sphingolipid family, which support the structure of the membrane of eukaryotic cells and mediate multiple cellsignaling pathways. Emerging evidence suggests that aberrant accumulation of ceramides has been linked to the development and progression of atherosclerosis by promoting low density lipoprotein infiltration to the endothelium [8,9]. Recent data also support their role as determinants of plaque components and predictors of plaque rupture in patients with STEMI [10], rendering these bioactive sphingolipids useful indicators for STEMI risk-stratification.…”

Emerging Roles of Ceramide in Cardiovascular Diseases

“…Moreover, multi-omics analysis of the intestinal microbiota of 161 patients with coronary artery disease revealed that intestinal microbes might affect the occurrence of atherosclerosis by regulating the metabolism of ceramide [ 92 ]. Ceramide has been identified as a subclinical marker of atherosclerosis and is considered useful for assessing the risk of atherosclerotic CVD that exceeds the standard risk factors [ 93 ]. Hazard ratios for Cer16:0, Cer18:0, and Cer24:1 and atherosclerotic cardiovascular outcomes in different clinical trials range from 1.1(95%CI, 1.02, 1.21) to 4.49 (95%CI, 2.24-8.99).…”

Effects of Wine and Tyrosol on the Lipid Metabolic Profile of Subjects at Risk of Cardiovascular Disease: Potential Cardioprotective Role of Ceramides

“…Antioxidants 2021, 10, 1679 2 of 14 Ceramides are a class of circulating sphingolipids that have received increasing attention due to their potential as CVD biomarkers [4] as they have been shown to better predict CVD risk irrespective of traditional risk factors [5]. Several studies in humans indicate that circulating ceramides are not only accurate biomarkers of adverse CVD outcomes but also drivers of CVD [6].…”