Cerebellar Balloon-Cell Metastasis of a Melanoma

Ferracini, R; Manetto,; Minghetti, G; Lanzanova, Giuseppe

doi:10.1177/030089168206800214

Cited by 5 publications

(6 citation statements)

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“…Only 4 cases of BCMM with brain metastasis have been reported to date (6)(7)(8)(9). In the current case, the cytological balloon cell change was associated with loss of HMB-45 expression.…”

Section: Discussionmentioning

confidence: 52%

Therapeutic Effectiveness of Immunoradiotherapy on Brain-metastatic BRAF/MEK Inhibitor-resistant Melanoma with Balloon Cell Change

Goto¹,

Shimauchi²,

Fukuchi³

et al. 2019

Acta Derm Venerol

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Wet wrap therapy, based on skin application of a double layer of tubular bandages or gauze with a moist first inner layer and a dry second outer layer, is utilized to treat various pruritic conditions, in particular severe and refractory atopic dermatitis. This review, by literature search, evaluates current knowledge about wet wrap therapy. Wet wrap therapy superimposed topical corticosteroids appears more efficient than emollients only, at least for short-time treatments. Despite higher efficacy, there is a tendency towards more frequent infections when topical corticosteroids are covered with wet wrap bandages compared to emollients only. While temporary suppression of hypothalamic-pituitary-adrenocortical-axis was seen due to systemic bioactivity of corticosteroids, no long-term observation studies on putative adverse effects were identified. One hypothesis suggests that wet wrap therapy may trigger increased lamellar body secretion resulting in recovery of the damaged intercellular lipid laminar structure. Otherwise, little investigation on mechanisms exists.

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“…Only 4 cases of BCMM with brain metastasis have been reported to date (6)(7)(8)(9). In the current case, the cytological balloon cell change was associated with loss of HMB-45 expression.…”

Section: Discussionmentioning

confidence: 52%

Therapeutic Effectiveness of Immunoradiotherapy on Brain-metastatic BRAF/MEK Inhibitor-resistant Melanoma with Balloon Cell Change

Goto¹,

Shimauchi²,

Fukuchi³

et al. 2019

Acta Derm Venerol

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“…10,24 Additional research instead suggests that melanocytic ballooning occurs because of melanosome enlargement and subsequent demelanization. 24,59 The further fusion of these transformed melanosomes is thought to create the classic vacuolated appearance of balloon cells. 60 Ferracini et al hypothesized that the vertical growth pattern of melanomas results in two distinct cell populationspigmented melanocytes and nonpigmented balloon cellswhich are commonly observed in histopathological preparations of BCM.…”

Section: Discussionmentioning

confidence: 99%

“…60 Ferracini et al hypothesized that the vertical growth pattern of melanomas results in two distinct cell populationspigmented melanocytes and nonpigmented balloon cellswhich are commonly observed in histopathological preparations of BCM. 59 Vertical growth phases of melanocytes are more frequently associated with metastatic transformation, which may explain the increased observation of balloon cell populations in metastatic melanomas. 59 Indeed, we observed a predominance of balloon cell infiltration in 100% of reported BCM metastases, with metastatic lesions often entirely replaced by balloon cell transformation.…”

Section: Discussionmentioning

confidence: 99%

“…59 Vertical growth phases of melanocytes are more frequently associated with metastatic transformation, which may explain the increased observation of balloon cell populations in metastatic melanomas. 59 Indeed, we observed a predominance of balloon cell infiltration in 100% of reported BCM metastases, with metastatic lesions often entirely replaced by balloon cell transformation. The majority of metastatic BCM cases also presented with an unknown primary origin, mirroring the presentation of our unique case.…”

Section: Discussionmentioning

confidence: 99%

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Balloon cell melanoma: a systematic review

et al. 2021

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Balloon cell melanoma (BCM) is a rare presentation of malignant melanoma characterized by large, foamy melanocytes lacking pigmentation. This is a comprehensive review of the clinical, dermoscopic, and histological features among BCM cases reported in the literature. A systematic review of all case reports and series published since 1970 was conducted via MEDLINE, Embase, and Web of Science, using "balloon cell melanoma" and synonymous search terms. Our systematic search identified 76 cases (49% male, 51% female) of BCM in the literature. The mean age at presentation was 57.81 years. Prior skin cancer, particularly melanoma (47%), accounted for 58% of pertinent medical history.Prominent clinical exam findings included raised (46%), ulcerated (73%) lesions larger than 1 cm (68%) in the lower extremities (35%). Median Breslow thickness of primary BCM cases was 2.5 mm. Hairpin vessels (75%) and structureless architecture (75%) were predominant on dermoscopy. Notable histopathology included large (47%), vacuolated (58%) cells with foamy cytoplasm (62%) and conspicuous nucleoli (27%). Positive S-100 immunohistochemistry (73%) was most frequently employed to diagnose BCM. We observed 47% primary and 53% metastatic BCM cases. Of metastatic BCMs, balloon cells in the primary lesion were unknown in 48%, devoid in 33%, and present in 20% of cases.All metastases displayed predominant balloon cell morphology. BCM may represent an advanced phase in the progression of malignant melanoma. Improved awareness of BCM characteristics among clinicians may reduce the risk of misdiagnoses.

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“…Balloon cell melanoma has also been reported as a primary lesion of the CNS arising from the leptomeninges . We were able to identify only a single prior case report of metastatic balloon cell melanoma to the cerebellum .…”

Section: Discussionmentioning

confidence: 99%