Cerebellar contributions to self-motion perception: evidence from patients with congenital cerebellar agenesis

Dahlem, Kilian; Valko, Yulia; Schmahmann, Jeremy D.; Lewis, Richard

doi:10.1152/jn.00763.2015

Cited by 21 publications

(11 citation statements)

References 44 publications

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“…However, neural detection thresholds for single otolith afferents are substantially higher (~10 cm/s 2 ) (Jamali et al, 2013; Yu et al, 2015), indicating that pooling the activities of multiple otolith afferents is required to give rise to perception of translational self-motion. By contrast, when considering differences in static head orientation relative to gravity, our results here have shown that single regular otolith afferents display discriminability values that are similar to those reported in psychophysical studies (~2 o ) (Clemens et al, 2011; Valko et al, 2012; Karmali et al, 2014; Janssen et al, 2011; Dahlem et al, 2016; Tarnutzer et al, 2013). This suggests that little additional pooling of afferent activities is actually required.…”

Section: Discussionsupporting

confidence: 85%

Coding strategies in the otolith system differ for translational head motion vs. static orientation relative to gravity

Jamali

Carriot

Chacron

et al. 2019

eLife

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The detection of gravito-inertial forces by the otolith system is essential for our sense of balance and accurate perception. To date, however, how this system encodes the self-motion stimuli that are experienced during everyday activities remains unknown. Here, we addressed this fundamental question directly by recording from single otolith afferents in monkeys during naturalistic translational self-motion and changes in static head orientation. Otolith afferents with higher intrinsic variability transmitted more information overall about translational self-motion than their regular counterparts, owing to stronger nonlinearities that enabled precise spike timing including phase locking. By contrast, more regular afferents better discriminated between different static head orientations relative to gravity. Using computational methods, we further demonstrated that coupled increases in intrinsic variability and sensitivity accounted for the observed functional differences between afferent classes. Together, our results indicate that irregular and regular otolith afferents use different strategies to encode naturalistic self-motion and static head orientation relative to gravity.

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Section: Discussionsupporting

confidence: 85%

Coding strategies in the otolith system differ for translational head motion vs. static orientation relative to gravity

Jamali

Carriot

Chacron

et al. 2019

eLife

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“…The hypothesis that cerebellar deficits lead to increased vestibular noise fits with results of several other studies that have documented impaired vestibular perception in cerebellar patients [8][9][10]. There is, however, also evidence of impaired visual motion processing in cerebellar patients [11] and perceptual deficits more broadly, particularly in the temporal domain [12].…”

supporting

confidence: 86%

Gravity Perception: The Role of the Cerebellum

MacNeilage

Glasauer

2018

Current Biology

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“…Cerebellar agenesis is a rare condition which is mainly associated with motor impairment, postural and balance disturbances (Glickstein, 1994; Velioglu et al, 1998). The absence of cerebellum or its functional disruption can lead to deficits that are not only related to motor processing but also to cognitive functions (Fiez et al, 1992; Arrigoni et al, 2015; Dahlem et al, 2016). Similarly, lesions to basal ganglia are associated with motor deficits and with various cognitive processes (linguistic, attentional, mnestic, and executive); in particular, their dysfunction has been related to neurodevelopmental disorders (Riva et al, 2018).…”

Section: Brain Mechanisms At the Root Of Consciousness And Attentionmentioning

confidence: 99%

The Neural Correlates of Consciousness and Attention: Two Sister Processes of the Brain

et al. 2019

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During the last three decades our understanding of the brain processes underlying consciousness and attention has significantly improved, mainly because of the advances in functional neuroimaging techniques. Still, caution is needed for the correct interpretation of these empirical findings, as both research and theoretical proposals are hampered by a number of conceptual difficulties. We review some of the most significant theoretical issues concerning the concepts of consciousness and attention in the neuroscientific literature, and put forward the implications of these reflections for a coherent model of the neural correlates of these brain functions. Even though consciousness and attention have an overlapping pattern of neural activity, they should be considered as essentially separate brain processes. The contents of phenomenal consciousness are supposed to be associated with the activity of multiple synchronized networks in the temporo-parietal-occipital areas. Only subsequently, attention, supported by fronto-parietal networks, enters the process of consciousness to provide focal awareness of specific features of reality.

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Cerebellar contributions to self-motion perception: evidence from patients with congenital cerebellar agenesis

Abstract: Dahlem K, Valko Y, Schmahmann JD, Lewis RF. Cerebellar contributions to self-motion perception: evidence from patients with congenital cerebellar agenesis.

Cited by 21 publications

References 44 publications

Coding strategies in the otolith system differ for translational head motion vs. static orientation relative to gravity

Coding strategies in the otolith system differ for translational head motion vs. static orientation relative to gravity

Gravity Perception: The Role of the Cerebellum

The Neural Correlates of Consciousness and Attention: Two Sister Processes of the Brain

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