1987
DOI: 10.1073/pnas.84.7.2101
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Cerebellar GABAergic processes: evidence for critical involvement in a form of simple associative learning in the rabbit.

Abstract: Converging evidence from electrophysiological recording and lesion studies suggests an essential role for the cerebellum in classical conditioning of the nictitating membrane response in the rabbit. The present study begins to delineate within this structure neurotransmitter systems that appear critical for the expression of this form of simple associative learning. Experiments reported here demonstrate that microinfusion of y-aminobutyric acid (GABA) antagonists (either bicuculline methiodide or picrotoxin) i… Show more

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Cited by 48 publications
(41 citation statements)
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“…In one study, application of the GABA antagonist picrotoxin into the anterior interpositus nucleus resulted in short-latency, reducedamplitude, prolonged conditioned responses but at a frequency similar to that observed in the absence of infusion (Garcia and Mauk 1998). These results are contradicted by other studies in which picrotoxin infusions into the interpositus blocked the expression of CRs completely (Mamounas et al 1987;Bao et al 2002). A much more precise elimination of cortical input can be achieved through sequential infusions of muscimol and picrotoxin.…”
Section: Complete Cortical Eliminationcontrasting
confidence: 51%
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“…In one study, application of the GABA antagonist picrotoxin into the anterior interpositus nucleus resulted in short-latency, reducedamplitude, prolonged conditioned responses but at a frequency similar to that observed in the absence of infusion (Garcia and Mauk 1998). These results are contradicted by other studies in which picrotoxin infusions into the interpositus blocked the expression of CRs completely (Mamounas et al 1987;Bao et al 2002). A much more precise elimination of cortical input can be achieved through sequential infusions of muscimol and picrotoxin.…”
Section: Complete Cortical Eliminationcontrasting
confidence: 51%
“…These results indicate that GABA and its actions on GABA receptors in the interpositus are important for both learning and performance of the CR. However, equivalent doses of strychnine had no effect on the CR or the UR, suggesting that glycine receptors are not involved (Mamounas et al 1987). Infusion of AP5 into the interpositus markedly impaired acquisition of the eyeblink CR (Chen and Steinmetz 2000).…”
Section: Interpositus Nucleusmentioning
confidence: 96%
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“…Specifically, non-human experiments have determined that activation of the CR is principally controlled by the cerebellar deep nuclei, specifically the interpositus nucleus (McCormick and Thompson, 1984a;Woodruff-Pak et al, 1985;Steinmetz et al, 1991;Sears and Steinmetz, 1991). Inhibitory projections from Purkinje cortical neurons modulate the activity of the interpositus, effectively manipulating the timing of the CR (Mamounas et al, 1987;Bao et al, 2002). Evidence suggests that one locus of CR timing modification is the anterior regions of cerebellar cortex (Green and Steinmetz, 2005), an area wherein lesions disrupt CR onset and peak latencies (McCormick and Thompson, 1984b;Logan, 1991;Perrett et al, 1993;Garcia et al, 1999) and, perhaps, CR acquisition (Lavond and Steinmetz, 1989;Garcia et al, 1999).…”
Section: Introductionmentioning
confidence: 99%
“…While shortterm memory is concerned, there is a temporary increase in sensitivity of synapses to neurotransmitter and in longterm memory-sensitivity of synapses to the consecutive stimulation is constant in character (Deutsch 1971, Mamounas et al 1987, Tronel et al 2004). …”
Section: Figmentioning
confidence: 99%