Cerebellar glioblastoma in childhood

Chin, Hong W.; Maruyama, Yosh; Tibbs, Phillip A.; Markesbery, William R.; Young, Byron

doi:10.1007/bf00165162

Cited by 12 publications

(8 citation statements)

References 15 publications

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“…In patients with cerebellopontine GBM the clinical features are similar to those of other aggressive fast growing infratentorial tumors. Signs and symptoms include headache, nausea, vomiting, and cerebellar dysfunction including ataxia, imbalance and unsteady gait, ipsilateral cranial nerves [9]- [11].…”

Section: Discussionmentioning

confidence: 99%

“…Other features as histology and biology of cerebellar GBM are similar to that of cerebral GBM.11 This includes malignant tumour cells, mitoses, hypercellularity, pleomorphism and neoangiogenesis. The presence of necrosis helps differentiate GBM from anaplastic astrocytoma or from well-differentiated astrocytoma [9].…”

Section: Discussionmentioning

confidence: 99%

“…This is attributed to rapid tumour progression, locally aggressive behaviour as well as the common findings of CSF pathway spread [12]. Early intervention has been advocated to increase the disease-free interval and to prolong survival includes, aggressive surgery as well as aggressive radiation and chemotherapy [9], [12]. Despite these measures; however, survival of children with CP angle GBM is very poor.…”

Section: Discussionmentioning

confidence: 99%

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Primary cerebellopontine angle glioblastoma in a child. A rare entity

Kaushik¹,

Pandey²

2019

roneuro

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Cerebellopontine angle extraaxial glioblastoma (GBM) is extremely rare at any age but especially in children. We reported a case of 14-year-old girl, who presented with nausea, vomiting and ataxia. She was evaluated with computed tomography (CT) and magnetic resonance imaging (MRI). Imaging demonstrated irregular ring enhancing right CP angle mass. The atypical findings of irregular ring enhancement, CP angle location and presentation in childhood, combine to make the prospective diagnosis of GBM a difficult one. This combination of findings has been reported very rarely.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Primary cerebellopontine angle glioblastoma in a child. A rare entity

Kaushik¹,

Pandey²

2019

roneuro

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“…Signs and symptoms include headache, nausea, vomiting, and cerebellar dysfunction including ataxia, imbalance and unsteady gait [1-4]. …”

Section: Discussionmentioning

confidence: 99%

“…The clinical features of patients with cerebellar GBM are similar to those of other aggressive fast growing infratentorial tumors. Signs and symptoms include headache, nausea, vomiting, and cerebellar dysfunction including ataxia, imbalance and unsteady gait [ 1 - 4 ].…”

Section: Discussionmentioning

confidence: 99%

Pediatric Cerebellar Hemorrhagic Glioblastoma Multiforme

Kalina

2012

Open Neuroimag J

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We report the case of an 11 year old boy who presented with nausea, vomiting and ataxia. He was evaluated with computed tomography (CT) and magnetic resonance imaging (MRI). Imaging demonstrated minimal enhancement and hemorrhage of a cerebellar mass. Cerebellar glioblastoma multiforme (GBM) is extremely rare in the cerebellum at any age but especially in children. The atypical findings of minimal enhancement, cerebellar location and hemorrhagic presentation combine to make the prospective diagnosis of GBM a difficult one. This rare combination of findings has not been previously reported.

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Poorly differentiated gliomas of the cerebellum. A study of 18 patients

Chamberlain

Silver

Levin

1990

Cancer

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Eighteen patients with poorly differentiated gliomas of the cerebellum were treated by the University of California San Francisco Neuro-Oncology Service between January 1977 and January 1987. Within this group pathologic diagnosis included five glioblastoma multiforme (28%), nine anaplastic astrocytomas (50%), and four mixed malignant gliomas (22%). The group included 13 male and five female patients with a median age at diagnosis of 23 years (range, 4-46 years). All patients underwent surgical resection, 16 of 18 received radiation therapy (12 limited-field irradiation and four whole-brain with or without a posterior fossa boost), and 16 of 18 received chemotherapy. Overall median survival was 31.5 months (range, 5-366 months). Ten patients (55%) died of recurrent disease with a median survival of 32 months (range, 5-128 months), two of whom manifested metastatic disease within the central nervous system (one parietal lobe and one cervical cord). Of the two extracerebellar metastatic recurrences, one patient failed at the junction of whole-brain irradiation and the cervical cord and one patient failed after inadequate posterior fossa irradiation. Eight patients (45%) are alive with a median follow-up of 27.5 months (range, 14-366 months). In this series recurrences of primary cerebellar anaplastic gliomas were locoregional failures. As a consequence, the authors suggest high-dose limited-field irradiation directed at the primary tumor as in their current strategy utilized for supratentorial gliomas.

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Cerebellar glioblastoma in childhood

Cited by 12 publications

References 15 publications

Primary cerebellopontine angle glioblastoma in a child. A rare entity

Primary cerebellopontine angle glioblastoma in a child. A rare entity

Pediatric Cerebellar Hemorrhagic Glioblastoma Multiforme

Poorly differentiated gliomas of the cerebellum. A study of 18 patients

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