Cerebellar mutism syndrome

Catsman‐Berrevoets, Coriene E.; Patay, Zoltán

doi:10.1016/b978-0-444-64189-2.00018-4

Cited by 42 publications

(25 citation statements)

References 136 publications

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“…The cerebellar mutism syndrome is a profound speech disorder that has been observed after the resection of large midline tumors (medulloblastoma) in children [18,127] (see also [128] for review) or cerebellitis [19]. It can be associated with oropharyngeal dyspraxia and ataxia and various manifestations of the so-called cognitive affective syndrome of the cerebellar patient [93].…”

Section: Cerebellar Mutismmentioning

confidence: 99%

Contribution of the Cerebellum and the Basal Ganglia to Language Production: Speech, Word Fluency, and Sentence Construction—Evidence from Pathology

Silveri

2020

Cerebellum

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Evidence reported in recent decades increasingly confirms that both the cerebellum and the basal ganglia, which are primarily involved in movement control, also have a significant role in a vast range of cognitive and affective functions. Evidence from pathology indicates that the disorders of some aspects of language production which follow damage of the cerebellum or respectively basal ganglia, i.e., disorders of speech, word fluency, and sentence construction, have identifiable neuropsychological profiles and that most manifestations can be specifically attributed to the dysfunctions of mechanisms supported by one or the other of these structures. The cerebellum and the basal ganglia are reciprocally interconnected. Thus, it is plausible that some disorders observed when damage involves one of these structures could be remote effects of abnormal activity in the other. However, in a purely clinical-neuropsychological perspective, primary and remote effects in the network are difficult to disentangle. Functional neuroimaging and non-invasive brain stimulation techniques likely represent the indispensable support for achieving this goal.

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Section: Cerebellar Mutismmentioning

confidence: 99%

Contribution of the Cerebellum and the Basal Ganglia to Language Production: Speech, Word Fluency, and Sentence Construction—Evidence from Pathology

Silveri

2020

Cerebellum

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“…in 2010 with an overall incidence rate of 11–29%. 2 This mutism develops with a mean latency of 1.7 days and persists for an average of 6–8 weeks. Although the general tendency is for mutism to slowly improve by way of dysarthria, speech rarely returns to normal.…”

Section: Discussionmentioning

confidence: 99%

“…CMS typically occurs in children and it is rarely found in adults (1%). 2 This condition is characterized by a significant lack or complete loss of speech and it is part of a large variety of symptoms which often involve ataxia, mood changes, and impaired swallowing and vision. The biological origin of CMS remains largely unclear and there are no standardized treatments.…”

Section: Introductionmentioning

confidence: 99%

Bromocriptine for the treatment of postoperative cerebellar mutism syndrome in pediatric patients: Three case reports

Amor-García

Fernández-Llamazares

Manrique-Rodríguez

et al. 2020

J Oncol Pharm Pract

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Introduction Cerebellar mutism syndrome (CMS) is a common complication after posterior fossa tumor resection. It is characterized by a significant lack or loss of speech. Its biological origin remains unclear and there are no standardized treatments. However, bromocriptine seems to be a possible treatment for this condition. Case report In this paper, we present three cases of pediatric patients (4, 5, and 17-year old) who developed CMS after posterior fossa tumor surgery. They were treated with bromocriptine to improve neurological symptoms. Management and outcome: Bromocriptine was started at a low dose and was progressively increased to reach the minimum effective dose. After four months of treatment, a normal and fluid speech was observed in the three patients. No discontinuation due to adverse events were reported. Discussion Bromocriptine has shown to be an effective and safe treatment for CMS in pediatric patients after posterior fossa tumor resection.

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“…This surgical approach is burdened by many intra-and postoperative complications (22), which are very much similar to those listed for the craniotomies presented above. One very specific complication, though, is cerebellar mutism syndrome, a postoperative syndrome typically arising 1 to 2 days after resection of a midline posterior fossa tumours, which consists of diminished speech progressing to mutism, emotional lability, hypotonia, and ataxia (23). While some of the symptoms recover after a few months, neuropsychological testing shows long-term deficits in language (agrammatism), executive function and verbal memory (24).…”

Section: Advancedmentioning

confidence: 99%

Pre-operative imaging and post-operative appearance of standard paediatric neurosurgical approaches: a training guide for neuroradiologists

2021

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A short-cut narrative review was conducted according to the SANRA guidelines to identify studies describing normal and abnormal postoperative radiological features of the most common paediatric neurosurgical procedures. Rather than focusing on the original pathology addressed by neurosurgical means, this review explored three main areas of operative neurosurgery: ventricular access, supratentorial & infratentorial craniotomies, and posterior fossa/craniocervical junction decompression. A total of twenty-three landmark papers were included for review based on their relevance to address the research question and serve as a practical guide for paediatric neuroradiology trainees and fellows. Accurate in text referencing of the ClinicalTrials.gov identifier, and weblink, has also been provided for all trials discussed in the results section. All the above is complemented by relevant iconography meant to describe a wide range of postoperative changes and early complications. Finally, the review is enriched by a discussion touching upon haemostatic agents, intentionally retained foreign bodies and the future of machine learning for neuroradiology reporting. Overall, the information presented in a systematic fashion will not only help trainees and fellows to deepen these topics and expand their knowledge in preparation for written and oral boards, but will also represent a useful resource for everyone including trained neuroradiologists and neurosurgeons themselves.

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Cerebellar mutism syndrome

Cited by 42 publications

References 136 publications

Contribution of the Cerebellum and the Basal Ganglia to Language Production: Speech, Word Fluency, and Sentence Construction—Evidence from Pathology

Contribution of the Cerebellum and the Basal Ganglia to Language Production: Speech, Word Fluency, and Sentence Construction—Evidence from Pathology

Bromocriptine for the treatment of postoperative cerebellar mutism syndrome in pediatric patients: Three case reports

Pre-operative imaging and post-operative appearance of standard paediatric neurosurgical approaches: a training guide for neuroradiologists

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