Cerebellar Theta-Burst Stimulation Selectively Enhances Lexical Associative Priming

Argyropoulos, Georgios P. D.

doi:10.1007/s12311-011-0269-y

Cited by 38 publications

(51 citation statements)

References 59 publications

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“…Also, the cerebellum is strongly activated by semantic discrimination tasks and the intensity of the activation correlates positively with the difficulty of the task (Xiang et al, 2003). Finally, it should be noted that cerebellar theta-burst stimulation with TMS has been shown to selectively enhance associative priming, while semantic priming was unaffected (Argyropoulos, 2011). …”

Section: The Cerebellum and High-level Cognitive Processingmentioning

confidence: 99%

Seeking a unified framework for cerebellar function and dysfunction: from circuit operations to cognition

D’Angelo

Casali²

2013

Front. Neural Circuits

268

282

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Following the fundamental recognition of its involvement in sensory-motor coordination and learning, the cerebellum is now also believed to take part in the processing of cognition and emotion. This hypothesis is recurrent in numerous papers reporting anatomical and functional observations, and it requires an explanation. We argue that a similar circuit structure in all cerebellar areas may carry out various operations using a common computational scheme. On the basis of a broad review of anatomical data, it is conceivable that the different roles of the cerebellum lie in the specific connectivity of the cerebellar modules, with motor, cognitive, and emotional functions (at least partially) segregated into different cerebro-cerebellar loops. We here develop a conceptual and operational framework based on multiple interconnected levels (a meta-levels hypothesis): from cellular/molecular to network mechanisms leading to generation of computational primitives, thence to high-level cognitive/emotional processing, and finally to the sphere of mental function and dysfunction. The main concept explored is that of intimate interplay between timing and learning (reminiscent of the “timing and learning machine” capabilities long attributed to the cerebellum), which reverberates from cellular to circuit mechanisms. Subsequently, integration within large-scale brain loops could generate the disparate cognitive/emotional and mental functions in which the cerebellum has been implicated. We propose, therefore, that the cerebellum operates as a general-purpose co-processor, whose effects depend on the specific brain centers to which individual modules are connected. Abnormal functioning in these loops could eventually contribute to the pathogenesis of major brain pathologies including not just ataxia but also dyslexia, autism, schizophrenia, and depression.

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Section: The Cerebellum and High-level Cognitive Processingmentioning

confidence: 99%

Seeking a unified framework for cerebellar function and dysfunction: from circuit operations to cognition

D’Angelo

Casali²

2013

Front. Neural Circuits

268

282

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“…). Argyropoulos and colleagues used TMS to transiently disrupt cerebellar function while healthy young adults performed a range of linguistic tasks . In one experiment, cerebellar TMS was found to affect associative linguistic priming where the relationship between the prime and target is based on sequential probabilities (e.g., pigeon‐HOLE).…”

Section: Cerebellar Internal Models Beyond Motor Control: the Case Ofmentioning

confidence: 99%

Cerebellar contributions to motor control and language comprehension: searching for common computational principles

Moberget

Ivry

2016

Ann. N.Y. Acad. Sci.

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The past 25 years have seen the functional domain of the cerebellum extend beyond the realm of motor control, with considerable discussion of how this subcortical structure contributes to cognitive domains including attention, memory, and language. Drawing on evidence from neuroanatomy, physiology, neuropsychology, and computational work, sophisticated models have been developed to describe cerebellar function in sensorimotor control and learning. In contrast, mechanistic accounts of how the cerebellum contributes to cognition have remained elusive. Inspired by the homogeneous cerebellar microanatomy and a desire for parsimony, many researchers have sought to extend mechanistic ideas from motor control to cognition. One influential hypothesis centers on the idea that the cerebellum implements internal models, representations of the context-specific dynamics of an agent’s interactions with the environment, enabling predictive control. We briefly review cerebellar anatomy and physiology, to review the internal model hypothesis as applied in the motor domain, before turning to extensions of these ideas in the linguistic domain, focusing on speech perception and semantic processing. While recent findings are consistent with this computational generalization, they also raise challenging questions regarding the nature of cerebellar learning, and may thus inspire revisions of our views on the role of the cerebellum in sensorimotor control.

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“…Although most TMS studies of linguistic functions have investigated the brain's responses to single "point-like" stimuli in event-related paradigms, the study of syntax requires considering the relation between at least two elements. Two studies have examined the phenomenon of lexical priming (Argyropoulos, 2011;Argyropoulos et al, 2011). In one experiment (Sakai et al, 2002), online paired-pulse TMS was applied to the pars opercularis of the left IFG and to the left MFG.…”

Section: Syntaxmentioning

confidence: 99%

Language

Cattaneo

2013

Handbook of Clinical Neurology

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Cerebellar Theta-Burst Stimulation Selectively Enhances Lexical Associative Priming

Cited by 38 publications

References 59 publications

Seeking a unified framework for cerebellar function and dysfunction: from circuit operations to cognition

Seeking a unified framework for cerebellar function and dysfunction: from circuit operations to cognition

Cerebellar contributions to motor control and language comprehension: searching for common computational principles

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