Cerebellar Volume in Offspring From Multiplex Alcohol Dependence Families

Hill, Shirley Y.; Muddasani, Srirangam; Prasad, Konasale M.; Nutche, Jeffrey; Steinhauer, Stuart R.; Scanlon, Joelle M.; McDermott, M. P.; Keshavan, Matcheri S.

doi:10.1016/j.biopsych.2006.01.007

Cited by 78 publications

(95 citation statements)

References 55 publications

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“…We do not have a clear-cut explanation for these associations. They may reflect the influence of factors other than alcohol on hippocampal size such as psychosocial stress (Smith, 1996;Winter and Irle, 2004), mood disorders (Campbell and Macqueen, 2004;Videbech and Ravnkilde, 2004), personality disorders (Laakso et al, 2000), withdrawal induced neurotoxicity (Crews et al, 2005;Prendergast et al, 2000), genetic susceptibility (Hill et al, 2006), or the modest size of our cohort. .…”

Section: Hippocampal Volumesmentioning

confidence: 98%

Chronic cigarette smoking modulates injury and short-term recovery of the medial temporal lobe in alcoholics

Gaździński

Durazzo

Yeh

et al. 2008

Psychiatry Research: Neuroimaging

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Memory function is largely mediated by medial temporal lobe (MTL), and its compromise has been observed in alcohol dependence and chronic cigarette smoking. The effects of heavy alcohol consumption and chronic smoking on hippocampal volumes and MTL metabolites and their recovery during abstinence from alcohol have not been assessed. Male alcoholics in treatment (ALC) [13 smokers (sALC) and 11 non-smokers (nsALC)] underwent quantitative magnetic resonance imaging and short-echo proton magnetic resonance spectroscopic imaging at one week and one month of sobriety. Outcome measures were compared to 14 age-matched, non-smoking light-drinkers and were related to visuospatial learning and memory. Over one month of abstinence, N-acetylaspartate, a neuronal marker, and membrane-associated choline-containing metabolites normalized in the MTL of nsALC, but remained low in the MTL of sALC. Metabolite concentration changes in both groups were associated with improvements in visuospatial memory. Hippocampal volumes increased in both groups during abstinence, but increasing volumes correlated with visuospatial memory improvements only in nsALC. In summary, chronic cigarette smoking in alcohol-dependent men appears to have adverse effects on MTL metabolite recovery during short-term sobriety. These data may also have implications for other conditions with established MTL involvement and significant smoking co-morbidity, such as schizophrenia-spectrum and mood disorders.

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Section: Hippocampal Volumesmentioning

confidence: 98%

Chronic cigarette smoking modulates injury and short-term recovery of the medial temporal lobe in alcoholics

Gaździński

Durazzo

Yeh

et al. 2008

Psychiatry Research: Neuroimaging

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“…Some of the previously published studies examined differences in brain volume between groups in a dichotomous fashion, such as comparing youth with and without familial alcoholism (Hanson et al, 2010), whereas others took a similar approach but included ultra-high-risk youth with multiplex familial AUDs in the family history group, thereby comparing high-and low-risk groups with very distinct levels of vulnerability toward AUDs (Hill et al, 2001(Hill et al, , 2007(Hill et al, , 2009(Hill et al, , 2011(Hill et al, , 2013a(Hill et al, , 2013b. However, the current study examined the degree of familial risk for alcoholism and its relationship with brain volume in a large cohort of youth all considered at risk because of the presence of at least one second-degree relative with an AUD.…”

Section: Discussionmentioning

confidence: 99%

“…Research using a region of interest (ROI) approach has found greater cerebellar volume (Hill et al, 2007(Hill et al, , 2011 and consistently smaller amygdalar and hippocampal (Benegal et al, 2007;Hanson et al, 2010;Hill et al, 2001Hill et al, , 2013b volumes in youth and young adults with familial alcoholism compared with controls. This suggests that morphometric characteristics of the brain may be particularly important markers of risk, but that structural variation related to risk may be present across brain areas.…”

mentioning

confidence: 99%

“…For example, interactions with familial history risk status and externalizing disorders were reported in a study that found smaller caudate volume in youth and young adults from multiplex families with AUDs (Hill et al, 2013a). Importantly, studies that have examined brain volume in individuals with familial alcoholism have included samples of youth with little to no experience with alcohol (Benegal et al, 2007;Hanson et al, 2010) or individuals who were largely free of abuse or dependence diagnoses during childhood/adolescence (Hill et al, 2001(Hill et al, , 2007(Hill et al, , 2009(Hill et al, , 2011(Hill et al, , 2013a(Hill et al, , 2013b, thereby controlling for confounding alcohol-related neurotoxic effects on the brain.…”

mentioning

confidence: 99%

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Family History Density of Alcoholism Relates to Left Nucleus Accumbens Volume in Adolescent Girls

Cservenka¹,

Gillespie²,

Michael³

et al. 2015

J. Stud. Alcohol Drugs

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ABSTRACT. Objective: A family history of alcoholism is a significant risk factor for the development of alcohol use disorders (AUDs). Because common structural abnormalities are present in reward and affective brain regions in alcoholics and those with familial alcoholism, the current study examined the relationship between familial loading of AUDs and volumes of the amygdala and nucleus accumbens (NAcc) in largely alcohol-naive adolescents, ages 12-16 years (N = 140). Method: The amygdala and NAcc were delineated on each participant's T1-weighted anatomical scan, using FMRIB Software Library's FMRIB Integrated Registration & Segmentation Tool, and visually inspected for accuracy and volume outliers. In the 140 participants with accurate segmentation (75 male/65 female), subcortical volumes were represented as a ratio to intracranial volume (ICV). A family history density (FHD) score was calculated for each adolescent based on the presence of AUDs in fi rst-and second-degree relatives (range: 0.03-1.50; higher scores represent a greater prevalence of familial AUDs). Multiple regressions, with age and sex controlled for, examined the association between FHD and left and right amygdala and NAcc volume/ICV. Results: There was a signifi cant positive relationship between FHD and left NAcc volume/ ICV (ǵR 2 = .04, p = .02). Post hoc regressions indicated that this effect was only signifi cant in females (ǵR 2 = .11, p = .006). Conclusions: This fi nding suggests that the degree of familial alcoholism, genetic or otherwise, is associated with alterations in reward-related brain structure. Further work will be necessary to examine whether FHD is related to future alcohol-related problems and reward-related behaviors. (J. Stud. Alcohol Drugs, 76, 47-56, 2015)

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“…alcohol use and cerebellar volume of healthy individuals have all been studied previously (Hutchinson et al;Keller et al, 2003;Laycock et al, 2008;Hill et al, 2007;Göçmen-Mas et al, 2009). In blind individuals, visual cortex and plasticity have also been studied profusely (Burton, 2003;Lambert et al, 2004).…”

mentioning

confidence: 99%

Comparison of Cerebellar Volume Between Subjects with Bilateral Congenital Blindness and Healthy Individuals

2013

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SUMMARY: Cerebellum regulates motor control and physical coordination. It is known that when eye and hand need to be worked in combination, cerebellum is active and it provides coordination between eye and hand. Cerebellar cortex atrophy appears with dismetry and saccadic eye movement. If there is no stimulant related to vision, how cerebellum is adopted under this circumstance? In order to explore this, 27 male and 16 female volunteers with bilateral congenital blindness were compared with 35 male and 33 female healthy volunteers in this study. MR images of cross-sectional sequential cerebellum of volunteers with 1.5 mm thickness were realized in coronal plane. The surface area of apparent cerebellum seen in cross-sections was calculated by using Onis (Ver. 2.1) programme. Surface area data obtained by systematic randomized sampling were converted to volume by Cavalieri method. Cerebellar volume of bilateral congenital blind male was 128.15 ± 11.11 cm 3 , and cerebellar volume of bilateral congenital blind female was 118.60 ±10.73 cm 3. Cerebellar volume for healthy men and women were 132.89 ± 12.51 cm 3 and 125.97 ± 10.78 cm 3 , respectively. It was revealed that cerebellar volume for bilateral congenital blind men was smaller than that of healthy men, but this difference was not significant. On the other hand cerebellar volume of bilateral congenital blind women was significantly smaller than that of healthy women (p<0.05). No asymmetry was detected between right and left side of cerebellum in both bilateral congenital blind and healthy subjects. 240alcohol use and cerebellar volume of healthy individuals have all been studied previously (Hutchinson et al.;Keller et al., 2003;Laycock et al., 2008;Hill et al., 2007;Göçmen-Mas et al., 2009). In blind individuals, visual cortex and plasticity have also been studied profusely (Burton, 2003;Lambert et al., 2004). However, cerebellar volume has not been a subject of research in people with bilateralcongenital blindness. How does the cerebellum adapt itself to the absence of visual stimulants? Our study will shed light on this issue. MATERIAL AND METHODIncluded in the study were 27 males (average age 39±12) and 16 females (average age 32±10) with bilateral congenital blindness. In order to make a comparison with healthy individuals, 35 males (average age 43±14) and 33 females (average age 37±9) were also included in the study. Following an approval from the ethics committee of Abant Izzet Baysal University Faculty of Medicine, consecutive images were obtained in coronal direction with 1.5 mm section thickness from the volunteers by using the 1.5 Tesla Magneton Symphony model MR device made in Germany, at the Department of Radiology in our hospital (Levitt et al., 1999). Images were saved in Dicom format. Images were then viewed by using the Onis (Ver. 2.1) software. All the sections showing cerebellum from anterior towards posterior were observed. Following a windowing procedure that would distinguish cerebellum from peripheral tissues, the same software was used t...

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Cerebellar Volume in Offspring From Multiplex Alcohol Dependence Families

Cited by 78 publications

References 55 publications

Chronic cigarette smoking modulates injury and short-term recovery of the medial temporal lobe in alcoholics

Chronic cigarette smoking modulates injury and short-term recovery of the medial temporal lobe in alcoholics

Family History Density of Alcoholism Relates to Left Nucleus Accumbens Volume in Adolescent Girls

Comparison of Cerebellar Volume Between Subjects with Bilateral Congenital Blindness and Healthy Individuals

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