2009
DOI: 10.1002/mrm.22010
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Cerebral activation by fasting induces lactate accumulation in the hypothalamus

Abstract: Obesity is a pandemic syndrome frequently associated with the most prevalent pathologies in developed countries, including diabetes, atherosclerosis, ischemic episodes, and cancer (1). Obesity results from an imbalance in the complex system of peripheral and intrahypothalamic pathways controlling appetite regulation and energy homeostasis (2). The hypothalamic control of energy homeostasis involves interaction between food intake stimulating neurons (orexigenic), expressing neuropeptide Y/agouti-related protei… Show more

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Cited by 17 publications
(24 citation statements)
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“…(2- 13 C) acetate or 13 C 2 acetate derived from colonic fermentation of (U- 13 C) inulin administered by gavage. 1 H-decoupled 13 C HR-MAS spectra of cerebral biopsies provide information on the operation of the tricarboxylic acid cycle (TCA) and the transcellular glutamate–glutamine and γ-amino butyric acid (GABA) cycles2021. Here we implemented the 13 C HR-MAS approach to investigate the metabolism of labelled [2- 13 C] acetate or 13 C 2 acetate in the hypothalamus of fasted mice as well as in biopsies from the ‘remaining brain’ obtained for comparison.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…(2- 13 C) acetate or 13 C 2 acetate derived from colonic fermentation of (U- 13 C) inulin administered by gavage. 1 H-decoupled 13 C HR-MAS spectra of cerebral biopsies provide information on the operation of the tricarboxylic acid cycle (TCA) and the transcellular glutamate–glutamine and γ-amino butyric acid (GABA) cycles2021. Here we implemented the 13 C HR-MAS approach to investigate the metabolism of labelled [2- 13 C] acetate or 13 C 2 acetate in the hypothalamus of fasted mice as well as in biopsies from the ‘remaining brain’ obtained for comparison.…”
Section: Resultsmentioning
confidence: 99%
“…), and the 13 C incorporation was normalized to the myo-inositol C1+C3 resonance (73.2 p.p.m. ), which provides a useful internal reference from which all 13 C resonances can be normalized independently of the amount of tissue2047, introducing appropriate corrections for nuclear Overhausser enhancement and saturation.…”
Section: Methodsmentioning
confidence: 99%
“…The characteristic and significant GABA increases in fasted animals (Violante et al, 2009) and MnCl 2 -infused animals (Zwingmann et al, 2004(Zwingmann et al, , 2007 relative to normal animals were already described following the measurements of brain extracts using Carbon-13 ( 13 C)-NMR spectroscopy. These metabolic changes in the glutamine-glutamate-GABA cycle were attributed to impaired cerebral energy metabolism.…”
Section: Spectroscopic Analysis Of the Hypothalamus Energy Metabolismmentioning
confidence: 94%
“…Lactate also increased in our in vivo study for CTL ( + Mn 2 + ) rats but not for OFS ( + Mn 2 + ) rats. Violante et al (2009) attributed the increased GABA levels of fasted mice to a reduction in the GABA degradation pathway since no significant increases in Glu and Gln were detected. Without MnCl 2 , Glu levels increased significantly in our OFS rats relative to CTL.…”
Section: Spectroscopic Analysis Of the Hypothalamus Energy Metabolismmentioning
confidence: 99%
“…Once released, GABA is taken-up by astrocytes through specific transporters and catabolized to succinate that enters the tricarboxylic acid cycle to generate glutamine [99]. Similarly fasting, possibly through stimulation of ghrelin secretion, increases hypothalamic GABA concentrations [133]. Hence, astrocytes take part in mediating ghrelin’s effects on hypothalamic synaptic transmission not only through modifications in neurotransmitter uptake, but also in their metabolism [19].…”
Section: Ghrelin and Astrocytes In Metabolic Controlmentioning
confidence: 99%