Cerebral Amyloidoma Accompanied by Sjögren’s Syndrome: A Case Report and Literature Review

Abstract

We present a 69-year-old woman with colorectal cancer and a left frontal lobe tumor that was diagnosed as a cerebral amyloidoma after surgical resection. Further postoperative systemic evaluation revealed another amyloidoma in her hip as well as Sjögren's syndrome. Systemic amyloidosis was not present. To the best of our knowledge, this is the first case of cerebral amyloidoma presenting as one of the multiple localized amyloidomas accompanied by Sjögren's syndrome. We also present a systematic review of 65 cerebral amyloidoma cases reported in the literature over the past 40 years and discuss patient characteristics and pathological and imaging findings associated with prognosis.

Primary cerebral immunoglobulin light chain amyloidoma in a patient with multiple sclerosis

“…One case series described 20 patients diagnosed with both marginal zone lymphoma and amyloid depositions, of whom 6 had a history of autoimmune disorders (such as Sjogren disease or lupus or a lupus-like syndrome; no multiple sclerosis) 25. Another case report describes a patient with a cerebral amyloidoma accompanied by Sjogren disease and another amyloidoma in the hip 27. The relationship between localised amyloidosis and autoimmune disorders is yet unclear.…”

Clinical and morphological features of localized laryngeal amyloidosis

“…На долю амилоидоза приходится 0,2-1,2% от всех доброкачественных опухолеподобных поражений гортани [8][9][10]. В литературе нередко встречается термин «амилоидома», обозначающий опухолевидный амилоидный очаг, который часто наблюдается при амилоидном поражении гортани, а также может обнаруживаться в головном мозге, коже, легких, подкожной жировой клетчатке [11][12][13].…”