Cerebral astroblastoma: A case report and review of literature

Agarwal, Vivek; Mally, Rahul; Palande, DA; Velho, Vernon

doi:10.4103/1793-5482.98657

Cited by 23 publications

(44 citation statements)

References 10 publications

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“…This has prognostic value, as patients with a low-grade astroblastoma survive for a longer time than those with the anaplastic form. The recurrence rate is very low and commonly occurs within 4.5 years (1,5,38,40) in contrast to our patient who was classified as low grade astroblastoma but had a recurrence after about 1 year with the same pathology despite GTR at the first surgery. This indicates that low-grade astroblastoma may also recur rapidly and that even if the tumor behaviour is more benign, it is still aggressive enough to cause recurrence.…”

Section: █ Case Reportcontrasting

confidence: 42%

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Astroblastoma; case report and review of literature

Barakat

Ammar²,

Salama³

et al. 2014

Turkish Neurosurgery

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ABSTRACTa gradual progressive course for the last two weeks. He presented with recurrent attacks of vomiting and confusion that rapidly worsened. Neurologically, the patient was confused and uncooperative with recurrent attacks of vomiting and bradycardia but no other neurological symptoms or signs. Computed tomography (CT) and magnetic resonance imaging (MRI) showed a well-demarcated enhancing spaceoccupying lesion, that was partially cystic, partially calcified in the subependymal area of the left frontal lobe partially projecting into the frontal horn of the lateral ventricle and causing obstructive hydrocephalus (Figure 1). We managed the patient as an urgent case in our intensive care unit (ICU) and performed urgent external ventricular drainage to manage the increased intracranial pressure (ICP). About one week later, we performed surgery for tumor resection by left frontal craniotomy. The tumor was pink-yellow in color, highly vascular, soft in consistency in parts and firm and calcified in other parts and was partially succable and well circumscribed which allowed total resection of the tumor. After the surgery, the patient ws transported routinely to the ICU for 3 days. Follow-up CT showed gross total resection (GTR) with mild postoperative brain edema at the site of surgery. The patient was followed up periodically every month for the first 3 months and then every 6 months without postoperative chemotherapy or radiotherapy and without recurrence. After one year, he showed a recurrent mass at the same site as the primary lesion in the follow-up MRI that was managed █ INTRODUCTION A stroblastoma is a rare glial tumor of the brain. It is estimated to account for 0.45-2.8% of all primary cerebral gliomas (1,30,31). Astroblastomas are initially described by Bailey and Cushing (3) and further characterized by Bailey and Bucy (2). However, much confusion has arisen regarding criteria for their diagnosis in the following years. Moreover, the origin of these tumors has been debated, because they share common histological characteristics with ependymomas and astrocytomas. Recent studies suggested that astroblastoma is a distinct histological and genetic entity (6,7,31,39). It has a distinctive characteristic of perivascular pseudorosettes with frequent vascular hyalinization. Perivascular pseudorosettes in astroblastoma have short and thick cytoplasmic processes and blunt-ended foot plates (30).We introduced a case of astroblastoma and reviewed all relevant literature of astroblastoma in order to discuss astroblastoma from the clinical, pathological, management, and prognostic view points. We tried to discover more secrets of astroblastoma and to introduce a standard approach to its diagnosis and management. █ CASE REPORTA forty-year old male patient complained of headache, nausea, vomiting, and deterioration of conscious level with Astroblastoma is a rare and distinct type of aggressive glial tumor for which there is much confusion regarding the diagnostic criteria. We present a case of astroblastoma and review...

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Section: █ Case Reportcontrasting

confidence: 42%

“…It is estimated to account for 0.45-2.8% of all primary cerebral gliomas (1,30,31). Astroblastomas are initially described by Bailey and Cushing (3) and further characterized by Bailey and Bucy (2).…”

Section: █ Introductionmentioning

confidence: 99%

Astroblastoma; case report and review of literature

Barakat

Ammar²,

Salama³

et al. 2014

Turkish Neurosurgery

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“…Other histological characteristics are lack of fibrillary background and compressing rather than infiltrative margin [6,7]. As histological variation, few cases of astroblastoma with rhabdoid features are reported [8,9].…”

Section: Introductionmentioning

confidence: 99%

A case of cerebral astroblastoma with rhabdoid features: a cytological, histological, and immunohistochemical study

et al. 2015

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“…[1] Other authors support GTR as the optimal way of treating a low-grade astroblastoma. [218] In a review of 85 patients by Sughrue et al ., those undergoing GTR experienced improved survival compared to those undergoing subtotal resection, with 85% survival at 5 years in the gross total resection group vs. 55% in the subtotal resection group. [20] Alternatively, Shen et al .…”

Section: Discussionmentioning

confidence: 99%

A case of astroblastoma: Radiological and histopathological characteristics and a review of current treatment options

Samples¹,

Henry²,

Bazán³

et al. 2016

Surg Neurol Int

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Background:Astroblastoma is a rare neuroepithelial tumor that often originates in the cerebral hemisphere of children and young adults. Diagnosis of this obscure neoplasm can be difficult because these tumors are so infrequently encountered and share common radiological and neuropathological features of other glial neoplasms. As such, it should be included in the differential diagnosis of astrocytoma and ependymoma if the clinical and radiographic features suggest it. Standardized treatment of astroblastomas remains under dispute because of the lack of knowledge regarding the tumor and a paucity of studies in the literature.Case Description:We present a case of a low-grade astroblastoma diagnosed in a 30-year-old female with seizures, headache, and vision changes. She underwent gross total resection and, without evidence of high-grade features, adjuvant therapy was not planned postoperatively. Post-operative surveillance suggested early recurrence, warranting referral to radiation therapy. Patient ended up expiring despite adjuvant therapy secondary to extensive recurrence and tumor metastasis.Conclusions:Astroblastoma must be considered in the differential of supratentorial tumors in children and young adults. Treatment of such, as suggested by most recent literature, includes gross total resection and adjuvant radiotherapy for lesions exhibiting high-grade features.

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Cerebral astroblastoma: A case report and review of literature

Cited by 23 publications

References 10 publications

Astroblastoma; case report and review of literature

Astroblastoma; case report and review of literature

A case of cerebral astroblastoma with rhabdoid features: a cytological, histological, and immunohistochemical study

A case of astroblastoma: Radiological and histopathological characteristics and a review of current treatment options

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