Cerebral blood flow and carbon dioxide reactivity in children with bacterial meningitis

Ashwal, Stephen; Stringer, Warren A.; Tomasi, Lawrence G.; Schnelder, Sanford; Thompson, Joseph R.; Perkin, Ron

doi:10.1016/s0022-3476(05)80683-3

Cited by 91 publications

(35 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Since the skull cannot expand, cerebral edema will result in increased intracranial pressure and impeded cerebral perfusion (16). Sometimes fatal brain stem herniation occurs.…”

Section: Outcome Of Meningococcal Meningitismentioning

confidence: 99%

Update on Meningococcal Disease with Emphasis on Pathogenesis and Clinical Management

Deuren¹,

Brandtzæg²,

Meer³

2000

Clinical Microbiology Reviews

398

236

View full text Add to dashboard Cite

“…Since the skull cannot expand, cerebral edema will result in increased intracranial pressure and impeded cerebral perfusion (16). Sometimes fatal brain stem herniation occurs.…”

Section: Outcome Of Meningococcal Meningitismentioning

confidence: 99%

Update on Meningococcal Disease with Emphasis on Pathogenesis and Clinical Management

Deuren¹,

Brandtzæg²,

Meer³

2000

Clinical Microbiology Reviews

398

236

View full text Add to dashboard Cite

“…A decrease in cerebral blood flow has been observed in patients with this infection [62][63][64][65]. The data on cerebral blood flow in animals with experimental meningitis are extensive and sometimes conflicting.…”

Section: Cerebral Blood Flow and Metabolism During Bacterial Meningitismentioning

confidence: 99%

Mechanisms of Brain Injury in Bacterial Meningitis: Workshop Summary

Pfister

Fontana²,

Täuber³

et al. 1994

Clinical Infectious Diseases

View full text Add to dashboard Cite

Morbidity and mortality associated with bacterial meningitis remain high, although antibiotic therapy has improved during recent decades. The major intracranial complications of bacterial meningitis are cerebrovascular arterial and venous involvement, brain edema, and hydrocephalus with a subsequent increase of intracranial pressure. Experiments in animal models and cell culture systems have focused on the pathogenesis and pathophysiology of bacterial meningitis in an attempt to identify the bacterial and/or host factors responsible for brain injury during the course of infection. An international workshop entitled "Bacterial Meningitis: Mechanisms of Brain Injury" was organized by the Department of Neurology at the University of Munich and was held in Eibsee, Germany, in June 1993. This conference provided a forum for the exchange of current information on bacterial meningitis, including data on the clinical spectrum of complications, the associated morphological alterations, the role of soluble inflammatory mediators (in particular cytokines) and of leukocyte-endothelial cell interactions in tissue injury, and the molecular mechanisms of neuronal injury, with potential mediators such as reactive oxygen species, reactive nitrogen species, and excitatory amino acids. It is hoped that a better understanding of the pathophysiological events that take place during bacterial meningitis will lead to the development of new therapeutic regimens.Although the recent licensure of Haeniophilus influenzae type b (Hib) polysaccharide conjugate protein vaccines has had a marked impact on the incidence of invasive Hib disease in the United States and Western Europe. bacterial meningitis overall remains a significant problem worldwide. In addition, despite the introduction of new antimicrobial agents and improved diagnostic techniques, the mortality and morbidity associated with bacterial meningitis remain unacceptably high. This discrepancy between a rapid bacteriologic response at the site of infection (i.e .. eradication of viable bacteria from the CSF due to treatment with potent bactericidal agents) and the persistence of the associated neurological sequelae and mortality has prompted intense investigation over the past two decades into the pathophysiology of this disease. Indeed. recent clinical studies have employed adjunctive agents (e.g .. dexamethasone) in an attempt to reduce mortality and alleviate neurological sequelae [1][2][3][4]. These studies and the resulting recommendations regarding the use of adjunctive dexamethasone have recently been reviewed [5.6].In line with the current emphasis on the pathogenesis and pathophysiology of bacterial meningitis. two workshops were held in California in the 1980s [7]. Recognizing that many advances have been made in this field in the several years since those meetings. the Department of Neurology at the University of Munich organized a similar workshop, which was held in Eibsce. Germanv. on 25 and 26 June 1993. As IS evident from its title-"Bacterial Meningitis: Mechanisms...

show abstract

“…CO 2 reactivity ͓i.e., change in CBF per change in partial pressure of CO 2 ͑pCO 2 ͔͒ is of interest, because impaired CO 2 reactivity has been associated with poor neurodevelopmental outcome and a higher risk of death in all age groups. [42][43][44] Neonates with complex forms of CHD are dependent on a patent ductus arteriosus for systemic blood flow, including CBF. In these neonates, management of the delicate balance of pulmonary blood flow and systemic blood flow is critical.…”

Section: Introductionmentioning

confidence: 99%

Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects

et al. 2010

View full text Add to dashboard Cite

Abstract. We employ a hybrid diffuse correlation spectroscopy ͑DCS͒ and near-infrared spectroscopy ͑NIRS͒ monitor for neonates with congenital heart disease ͑n =33͒. The NIRS-DCS device measured changes during hypercapnia of oxyhemoglobin, deoxyhemoglobin, and total hemoglobin concentrations; cerebral blood flow ͑rCBF DCS ͒; and oxygen metabolism ͑rCMRO 2 ͒. Concurrent measurements with arterial spin-labeled magnetic resonance imaging ͑rCBF ASL-MRI , n =12͒ cross-validate rCBF DCS against rCBF ASL-MRI , showing good agreement ͑R = 0.7, p = 0.01͒. The study demonstrates use of NIRS-DCS on a critically ill neonatal population, and the results indicate that the optical technology is a promising clinical method for monitoring this population.

show abstract

Cerebral blood flow and carbon dioxide reactivity in children with bacterial meningitis

Cited by 91 publications

References 22 publications

Update on Meningococcal Disease with Emphasis on Pathogenesis and Clinical Management

Update on Meningococcal Disease with Emphasis on Pathogenesis and Clinical Management

Mechanisms of Brain Injury in Bacterial Meningitis: Workshop Summary

Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects

Contact Info

Product

Resources

About