Cerebral blood flow in humans following resuscitation from cardiac arrest.

Cohan, Stanley; Mun, Seongpyo; Petite, J P; Correia, John A.; Silva, A T Tavelra Da; Waldhorn, Richard

doi:10.1161/01.str.20.6.761

Cited by 86 publications

(36 citation statements)

References 55 publications

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“…However, the values for CBF were significantly lower than the study by Cohan et al 4 and were only hyperperfused relative to controls in patients who survived. 5 A study by Nogami et al 6 using xenon-CT perfusion 8 -20 days after the hypoxic event showed a decrease in hemispheric CBF in patients with a severe disability, but also noted hyperperfusion within the putamen.…”

Section: Resultscontrasting

confidence: 71%

“…20,36,38 Xenon-CT perfusion has been used to evaluate CBF after cardiac resuscitation. A study by Cohan et al 4 showed an increase in global whole-brain CBF by up to 300% in nonsurviving patients. The CBF values obtained in the 6 patients who died in the Cohan et al study closely parallel the mean and range of our ASL data.…”

Section: Resultsmentioning

confidence: 98%

“…17,27,28 Little human research exists regarding the effect of global anoxia on autoregulation. 4,20,[29][30][31][32][33][34][35][36][37] Animal models have shown a loss of cerebral vascular resistance in the postanoxic state resulting in uncontrolled hyperperfusion. [38][39][40][41][42] Cerebral blood volume has been shown to increase with loss of autoregulation secondary to ischemia, but no large studies have demonstrated a similar relationship for CBF.…”

Section: Resultsmentioning

confidence: 99%

“…Xenon CT perfusion has been used to evaluate postresuscitation patients with mixed results. [4][5][6] Other cerebral perfusion methods, such as nuclear medicine hexamethylpropyleneamine oxime singlephoton emission CT and O-15 positron-emission tomography (PET), rely on differences in regional perfusion and may not detect a global symmetric hyperperfusion pattern. 7 The goal of this study was to use ASL to characterize the perfusion patterns encountered after anoxic injury to the brain.…”

mentioning

confidence: 99%

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Anoxic Injury-Associated Cerebral Hyperperfusion Identified with Arterial Spin-Labeled MR Imaging

Pollock¹,

Whitlow²,

Deibler³

et al. 2008

AJNR Am J Neuroradiol

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Section: Resultscontrasting

confidence: 71%

Section: Resultsmentioning

confidence: 98%

Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

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Anoxic Injury-Associated Cerebral Hyperperfusion Identified with Arterial Spin-Labeled MR Imaging

Pollock¹,

Whitlow²,

Deibler³

et al. 2008

AJNR Am J Neuroradiol

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“…1 A lack of oxygen to the brain for just a few minutes during CA can result in diffuse acquired brain injury (ABI). 2 In clinical practice the main method of identifying ABI and predicting outcome is clinical examination. 3 Clinical examination to identify ABI includes level of consciousness, presence of seizure activity, brainstem reflexes and vestibular reflexes.…”

Section: Introductionmentioning

confidence: 99%

The psychosocial outcomes of anoxic brain injury following cardiac arrest

et al. 2014

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Aim of the study: This exploratory study aimed to investigate the psychosocial outcomes for cardiac arrest survivors and explore if there is a greater impact on psychosocial outcome for individuals experiencing anoxic brain injury as a result of the cardiac arrest. Methods: Self-report measures were used to compare the quality of life, social functioning and symptoms of anxiety, depression and post-traumatic stress of individuals with and without anoxic brain injury. Secondary measures of subjective memory and executive difficulties were also used. Fifty-six participants (27 with anoxia, 29 without anoxia) took part in the study between six months and four years after experiencing cardiac arrest. Results: A MANOVA identified a significant difference between the two groups, with the anoxia group reporting more psychosocial difficulties. They reported more social functioning difficulties and more anxiety, depression and post-traumatic stress symptoms. There was, however, no significant difference in self-reported quality of life between the two groups. Conclusion: As the first known study to compare psychosocial outcomes for cardiac arrest survivors experiencing anoxic brain injury with those without anoxia, the current results suggest that cardiac arrest survivors with subsequent acquired brain injury experience more psychosocial difficulties. This could be due to a combination of neuropsychological, social and psychological factors. Â© 2014 Elsevier Ireland Ltd

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