Cerebral Blood Volume and Hemoglobin Oxygen Saturation Monitoring in Neonatal Brain by near IR Spectroscopy

Ferrari, Marco; Marchis, C De; Giannini, I; Nicola, Anna Di; Agosti, Massimo; Nodari, S; Bucci, G.

doi:10.1007/978-1-4684-5188-7_27

Cited by 63 publications

(23 citation statements)

References 15 publications

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“…Subsequently JObsis showed that by using near infrared light (NIR), tissue absorption became sufficiently low to make transillumination of the cat head possible (JObsis, 1977). In the near infrared region (700-1300 nm) there is sufficient spectral information available to permit changes in the concentration of haemoglobin and cytochrome a~ to be calculated, and hence changes in the oxygenation state of the brain (Brazy et aI., 1985(Brazy et aI., , 1986Ferrari et al, 1986;Fox et aI., 1985). This technique is now used routinely to monitor cerebral oxygenation and haemodynamics in the human newborn infant (Wyatt et aI., 1986;Edwards et aI., 1988), using an instrument designed to transilluminate the heads of most newborn infants .…”

Section: Introducfionmentioning

confidence: 98%

The Effect of Optode Positioning on Optical Pathlength in Near Infrared Spectroscopy of Brain

Zee

Arridge

Cope

et al. 1990

Advances in Experimental Medicine and Biology

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Section: Introducfionmentioning

confidence: 98%

The Effect of Optode Positioning on Optical Pathlength in Near Infrared Spectroscopy of Brain

Zee

Arridge

Cope

et al. 1990

Advances in Experimental Medicine and Biology

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“…13 First clinical applications of this technique have principally been focused on the cerebral circulation. 12,17,38,39 More recent studies indicate the clinical relevance of NIRS measurement on muscle. The NIRS technique has been used to quantify human skeletal muscle oxygen consumption, 5,8 blood flow, 9,11 and venous saturation.…”

Section: Introductionmentioning

confidence: 99%

Parameters of Postocclusive Reactive Hyperemia Measured by Near Infrared Spectroscopy in Patients with Peripheral Vascular Disease and in Healthy Volunteers

Kragelj

Jarm

Erjavec³

et al. 2001

Annals of Biomedical Engineering

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Abstract-The main purpose of our study was to determine the parameters of the postocclusive reactive hyperemia test that could help and provide the clinician with information about the tissue oxygenation, the severity of the disease, and the results of the applied therapies. Near infrared spectroscopy ͑NIRS͒ proved to be a valid noninvasive trend monitor useful for investigating the physiology of oxygen transport to tissue. Important advantages of NIRS over transcutaneous oximetry (TcpO 2 ) are: ͑a͒ a more dynamic nature of the NIRS signals which reflects more closely the actual response of the peripheral vasculature to the occlusive provocation; ͑b͒ larger sampling volume; and ͑c͒ the ability of assessing tissue oxygenation at deeper tissue levels. We demonstrated that the time parameters of reactive hyperemia, the rate of reactive hyperemia, and the maximal change during reactive hyperemia, all calculated from the oxyhemoglobin (HbO 2 ) signal of the NIRS, clearly distinguish between healthy volunteers and patients with vascular disorder. The time parameters of reactive hyperemia were significantly longer (pϽ0.01), and the rate of reactive hyperemia (pϭ0.01) as well as the maximal change during reactive hyperemia (pϭ0.02) were significantly lower in patient group compared to healthy volunteers. These parameters were also in good correlation with the values of ankle brachial index ͑ABI͒ and the resting values of oxygen partial pressure (TcpO 2 ). Values of the chosen parameters obtained from the HbO 2 signal were further compared between groups of diabetic and nondiabetic patients with peripheral vascular disease. Although longer time parameters of reactive hyperemia and lower rates of hyperemic response were detected, the difference between both groups was not statistically significant.

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“…The development over the last 30 years of noninvasive optical techniques such as optical reflectance spectroscopy (ORS) (2,18,22,33) and near-infrared spectroscopy (NIRS) (7, 23) has significantly advanced our understanding of the hemodynamics of the cutaneous (1, 20), muscle (36), cerebral (11,13,29,48), and gastrointestinal (15, 38) microcirculation. Furthermore, mean blood saturation (S mb O 2 ) and tissue oxygen index (TOI) derived by ORS and NIRS, respectively, evoke a concept that we can also measure the oxygen delivery to the tissue.…”

mentioning

confidence: 99%

Is mean blood saturation a useful marker of tissue oxygenation?

Thorn¹,

Matcher²,

Meglinski³

et al. 2009

American Journal of Physiology-Heart and Circulatory Physiology

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Thorn CE, Matcher SJ, Meglinski IV, Shore AC. Is mean blood saturation a useful marker of tissue oxygenation?. Am J Physiol Heart Circ Physiol 296: H1289 -H1295, 2009. First published March 13, 2009 doi:10.1152/ajpheart.01192.2008.-Increasingly we are monitoring the distribution of oxygen through the microcirculation using optical techniques such as optical reflectance spectroscopy (ORS) and near-infrared spectroscopy. Mean blood oxygen saturation (SmbO2) and tissue oxygenation index measured by these two techniques, respectively, evoke a concept of the measurement of oxygen delivery to tissue. This study aims to establish whether SmbO2 is an appropriate indicator of tissue oxygenation. Spontaneous fluctuations in SmbO2 observed as changes in concentration of oxyhemoglobin ([HbO2]) and deoxyhemoglobin ([Hb]) were measured by ORS in the skin microcirculation of 30 healthy subjects (15 men, age 21-42 yr). Fourier analysis identified two distinctly different spontaneous falls in SmbO2. The first type of swing, thought to be induced by fluctuations in arterial blood volume, resulted from the effects of respiration, endothelial, sympathetic, and myogenic activity. There was no apparent change in [Hb]. In contrast, a second type of swing resulted from a fall in [HbO2] accompanied by a rise in [Hb] and was only induced by endothelial and sympathetic activity. Thus the same fall in SmbO2 can be induced by two distinct responses. A "type I" swing does not suggest an inadequacy in oxygen delivery whereas a "type II" swing may indicate a change in oxygen delivery from blood to tissue. SmbO2 alone cannot therefore be accepted as a definitive marker of tissue oxygenation.optical reflectance spectroscopy; microcirculation THE EXQUISITE STRUCTURE OF the microcirculation is designed to deliver nutrients to every cell in the human body. The development over the last 30 years of noninvasive optical techniques such as optical reflectance spectroscopy (ORS) (2,18,22,33) and near-infrared spectroscopy (NIRS) (7, 23) has significantly advanced our understanding of the hemodynamics of the cutaneous (1, 20), muscle (36), cerebral (11,13,29,48), and gastrointestinal (15, 38) microcirculation. Furthermore, mean blood saturation (S mb O 2 ) and tissue oxygen index (TOI) derived by ORS and NIRS, respectively, evoke a concept that we can also measure the oxygen delivery to the tissue. These parameters are increasingly being identified as indicators of tissue hypoxia (1,3,8,15,21,28,34,47), which is a common end product of circulatory shock and a primary target for resuscitation efforts (5, 37).The primary goal of this study was to establish whether cutaneous tissue oxygen saturation (i.e., S mb O 2 ) derived by ORS is an appropriate indicator of tissue oxygenation. A further goal was to explore differences in S mb O 2 across cuta- [Hb] across all the vessels of the microcirculation of the skin. Therefore the derived S mb O 2 is a mean blood oxygen saturation across arterioles, capillaries, and venules. METHODS ORS.The ORS instrumentatio...

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Cerebral Blood Volume and Hemoglobin Oxygen Saturation Monitoring in Neonatal Brain by near IR Spectroscopy

Cited by 63 publications

References 15 publications

The Effect of Optode Positioning on Optical Pathlength in Near Infrared Spectroscopy of Brain

The Effect of Optode Positioning on Optical Pathlength in Near Infrared Spectroscopy of Brain

Parameters of Postocclusive Reactive Hyperemia Measured by Near Infrared Spectroscopy in Patients with Peripheral Vascular Disease and in Healthy Volunteers

Is mean blood saturation a useful marker of tissue oxygenation?

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