Cerebral blood volume in the sleep measured by near‐infrared spectroscopy

Shiotsuka, Shinichi; Atsumi, Yoshikata; Ogata, S.; Yamamoto, Rieko; Igawa, Mariko; Takahashi, Kazumi; Hirasawa, Hideto; Koyama, Keiko; Maki, Atsushi; Yamashita, Yuichi; Koizumi, Hideaki; Toru, Michio

doi:10.1111/j.1440-1819.1998.tb01012.x

Cited by 15 publications

(5 citation statements)

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“…This is the first study to present a comprehensive account of the time evolution of hemodynamic parameters in sleep stage transitions. Our observations on the W→LS and LS→W transitions are consistent with a general reduction in physiological activity and alertness in sleep compared to wakefulness, and in agreement with previous studies [10] , [11] , [26] – [28] . In some cases, our results on sleep stage transitions cannot be directly compared with the results of previous studies since they have compared hemodynamics and metabolism between REM, SWS, and W instead of comparing these states to LS [27] , [48] .…”

Section: Discussionsupporting

confidence: 93%

Spontaneous Hemodynamic Oscillations during Human Sleep and Sleep Stage Transitions Characterized with Near-Infrared Spectroscopy

et al. 2011

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Understanding the interaction between the nervous system and cerebral vasculature is fundamental to forming a complete picture of the neurophysiology of sleep and its role in maintaining physiological homeostasis. However, the intrinsic hemodynamics of slow-wave sleep (SWS) are still poorly known. We carried out 30 all-night sleep measurements with combined near-infrared spectroscopy (NIRS) and polysomnography to investigate spontaneous hemodynamic behavior in SWS compared to light (LS) and rapid-eye-movement sleep (REM). In particular, we concentrated on slow oscillations (3–150 mHz) in oxy- and deoxyhemoglobin concentrations, heart rate, arterial oxygen saturation, and the pulsation amplitude of the photoplethysmographic signal. We also analyzed the behavior of these variables during sleep stage transitions. The results indicate that slow spontaneous cortical and systemic hemodynamic activity is reduced in SWS compared to LS, REM, and wakefulness. This behavior may be explained by neuronal synchronization observed in electrophysiological studies of SWS and a reduction in autonomic nervous system activity. Also, sleep stage transitions are asymmetric, so that the SWS-to-LS and LS-to-REM transitions, which are associated with an increase in the complexity of cortical electrophysiological activity, are characterized by more dramatic hemodynamic changes than the opposite transitions. Thus, it appears that while the onset of SWS and termination of REM occur only as gradual processes over time, the termination of SWS and onset of REM may be triggered more abruptly by a particular physiological event or condition. The results suggest that scalp hemodynamic changes should be considered alongside cortical hemodynamic changes in NIRS sleep studies to assess the interaction between the autonomic and central nervous systems.

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Section: Discussionsupporting

confidence: 93%

Spontaneous Hemodynamic Oscillations during Human Sleep and Sleep Stage Transitions Characterized with Near-Infrared Spectroscopy

et al. 2011

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“…The sleep stage transition from wakefulness to sleep is usually accompanied by a subjective experience of self-awareness reduction. According to the temporal trend of NIRS signals, a decreasing trend in HbO 2 and tHb, and an increasing trend in HHb was visually detected upon transitioning from wakefulness to sleep (50,51). The results using grand averaged values of wakefulness and sleep were consistent with the visual inspection of the temporal trend during the initiation of sleep, showing larger values in HbO 2 and tHb, and smaller values in HHb after entering sleep (34,(52)(53)(54).…”

Section: Cerebral Hemodynamics In Regular Sleep Stagingsupporting

confidence: 74%

“…Premature infants, particularly, are susceptible to brain impairment on the left side of the temporal areas. Although it is convenient for the long-term monitoring of cerebral hemodynamic changes in the prefrontal region during sleep, the different patterns and activation in different cerebral regions (51,52,98) indicate that it is necessary to monitor different cerebral regions using multiple channels.…”

Section: Discussion Of Experimental Designmentioning

confidence: 99%

A Review of Cerebral Hemodynamics During Sleep Using Near-Infrared Spectroscopy

Ren

Jiang

et al. 2020

Front. Neurol.

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Investigating cerebral hemodynamic changes during regular sleep cycles and sleep disorders is fundamental to understanding the nature of physiological and pathological mechanisms in the regulation of cerebral oxygenation during sleep. Although sleep neuroimaging methods have been studied and have been well-reviewed, they have limitations in terms of technique and experimental design. Neurologists are convinced that Near-infrared spectroscopy (NIRS) provides essential information and can be used to assist the assessment of cerebral hemodynamics, and numerous studies regarding sleep have been carried out based on NIRS. Thus, a brief historical overview of the sleep studies using NIRS will be helpful for the biomedical students, academicians, and engineers to better understand NIRS from various perspectives. In this study, the existing literature on sleep studies is reviewed, and an overview of the NIRS applications is synthesized and provided. The paper first reviews the application scenarios, as well as the patterns of fluctuation of NIRS, which includes the investigation in regular sleep and sleep-disordered breathing. Various factors such as different sleep stages, populations, and degrees of severity were considered. Furthermore, the experimental design and signal processing, as well as the regulation mechanisms involved in regular and pathological sleep, are investigated and discussed. The strengths and weaknesses of the existing NIRS applications are addressed and presented, which can direct further NIRS analysis and utilization.

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“…The majority of these NIRS sleep studies investigated cerebral [Hb] and [HbO] changes associated with transitions across different sleep stages, and interpreted these changes in terms of CBV, CBFV and CMRO 2 . The increase in [Hb] and decrease in [HbO] found by Fantini et al (Fantini et al, 2003) and Shiotsuka et al (Shiotsuka et al, 1998) immediately after sleep onset were assigned to a decrease in the CBF during the first non-REM sleep stages (Fantini, et al, 2003). An opposite trend (decrease in [Hb], increase in [HbO]) associated with transitions to deepest, slow-wave sleep stages was considered to be consistent with a decrease of CMRO 2 (Madsen et al, 1991b).…”

Section: Introductionmentioning

confidence: 95%

Phase-amplitude investigation of spontaneous low-frequency oscillations of cerebral hemodynamics with near-infrared spectroscopy: A sleep study in human subjects

et al. 2012

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We have investigated the amplitude and phase of spontaneous low-frequency oscillations (LFOs) of the cerebral deoxy- and oxy-hemoglobin concentrations ([Hb] and [HbO]) in a human sleep study using near-infrared spectroscopy (NIRS). Amplitude and phase analysis was based on the analytic signal method, and phasor algebra was used to decompose measured [Hb] and [HbO] oscillations into cerebral blood volume (CBV) and flow velocity (CBFV) oscillations. We have found a greater phase lead of [Hb] vs. [HbO] LFOs during non-REM sleep with respect to the awake and REM sleep states (maximum increase in [Hb] phase lead: ~π/2). Furthermore, during non-REM sleep, the amplitudes of [Hb] and [HbO] LFOs are suppressed with respect to the awake and REM sleep states (maximum amplitude decrease: 87%). The associated cerebral blood volume and flow velocity oscillations are found to maintain their relative phase difference during sleep, whereas their amplitudes are attenuated during non-REM sleep. These results show the potential of phase-amplitude analysis of [Hb] and [HbO] oscillations measured by NIRS in the investigation of hemodynamics associated with cerebral physiology, activation, and pathological conditions.

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Cerebral blood volume in the sleep measured by near‐infrared spectroscopy

Cited by 15 publications

References 0 publications

Spontaneous Hemodynamic Oscillations during Human Sleep and Sleep Stage Transitions Characterized with Near-Infrared Spectroscopy

Spontaneous Hemodynamic Oscillations during Human Sleep and Sleep Stage Transitions Characterized with Near-Infrared Spectroscopy

A Review of Cerebral Hemodynamics During Sleep Using Near-Infrared Spectroscopy

Phase-amplitude investigation of spontaneous low-frequency oscillations of cerebral hemodynamics with near-infrared spectroscopy: A sleep study in human subjects

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