Cerebral cortex and hippocampus respond differently after post-natal exposure to uranium

Lestaevel, Philippe; Bensoussan, H; Delissen, Olivia; Vacher, Claire-Marie; Dublineau, Isabelle; Voisin, Philippe; Taouis, Mohammed

doi:10.2131/jts.38.803

Cited by 11 publications

(9 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This behavioral toxicity is expressed by increased locomotor activity (Briner and Muray, 2005;Bellès et al, 2005), significantly decreased spatial working memory capacities , increased anxiety , and shorter paradoxical sleep . In addition to the cerebral cortex (Lestaevel et al, 2013), the hippocampus also seems to be a major target of U-induced neurotoxicity (Pellmar et al, 1999b).…”

Section: Introductionmentioning

confidence: 99%

Uranium modifies or not behavior and antioxidant status in the hippocampus of rats exposed since birth

et al. 2015

Self Cite

View full text Add to dashboard Cite

-In view of the known sensitivity of the developing central nervous system to pollutants, we sought to assess the effects of exposure to uranium (U) -a heavy metal naturally present in the environment -on the behavior of young rats and the impact of oxidative stress on their hippocampus. Pups drank U (in the form of uranyl nitrate) at doses of 10 or 40 mg.L -1 for 10 weeks from birth. Control rats drank mineral water. Locomotor activity in an open field and practice effects on a rotarod device decreased in rats exposed to 10 mg.L -1 (respectively, -19.4% and -51.4%) or 40 mg.L -1 (respectively, -19.3% and -55.9%) in compared with control rats. Anxiety (+37%) and depressive-like behavior (-50.8%) were altered by U exposure only at 40 mg.L -1 . Lipid peroxidation (+35%) and protein carbonyl concentration (+137%) increased significantly after exposure to U at 40 mg.L -1 . A significant increase in superoxide dismutase (SOD, +122.5%) and glutathione peroxidase (GPx, +13.6%) activities was also observed in the hippocampus of rats exposed to 40 mg.L -1 . These results demonstrate that exposure to U since birth alters some behaviors and modifies antioxidant status.

show abstract

Section: Introductionmentioning

confidence: 99%

Uranium modifies or not behavior and antioxidant status in the hippocampus of rats exposed since birth

et al. 2015

Self Cite

View full text Add to dashboard Cite

show abstract

“…and metalloids. Such studies published these past three years in the Journal of Toxicological Sciences investigated the toxicity of many types of metals, including cadmium (Ohtani et al, 2013;Miura et al, 2013;Baba et al, 2014;Du et al, 2014;Park et al, 2015;Lukkhananan et al, 2015), mercury (Yoshida et al, 2013;Kim et al, 2014), methylmercury (Hwang et al, 2013a(Hwang et al, , 2013bIwai-Shimada et al, 2013;Chang et al, 2013;Hirooka et al, 2013;Kim et al, 2013;Watanabe et al, 2013;Shao et al, 2015;Toyama et al, 2015), aluminum (Zhang et al, 2013;Jinzhu et al, 2015), manganese (Fujishiro et al, 2013), uranium (Lestaevel et al, 2013), arsenic (Tokumoto et al, 2013;Wang et al, 2015), arsine (Kato et al, 2014), organic bismuth (Kohri et al, 2015), chromium (Kimura et al, 2015), and tributyltin (Oyanagi et al, 2015). Although methylmercury is one of the organic-inorganic hybrid molecules (the minimum unit!…”

mentioning

confidence: 99%

Toxicology of organic-inorganic hybrid molecules: bio-organometallics and its toxicology

2016

View full text Add to dashboard Cite

Bio-organometallics is a research strategy of biology that uses organic-inorganic hybrid molecules. The molecules are expected to exhibit useful bioactivities based on the unique structure formed by interaction between the organic structure and intramolecular metal(s). However, studies on both biology and toxicology of organic-inorganic hybrid molecules have been incompletely performed. There can be two types of toxicological studies of bio-organometallics; one is evaluation of organic-inorganic hybrid molecules and the other is analysis of biological systems from the viewpoint of toxicology using organic-inorganic hybrid molecules. Our recent studies indicate that cytotoxicity of hybrid molecules containing a metal that is nontoxic in inorganic forms can be more toxic than that of hybrid molecules containing a metal that is toxic in inorganic forms when the structure of the ligand is the same. Additionally, it was revealed that organic-inorganic hybrid molecules are useful for analysis of biological systems important for understanding the toxicity of chemical compounds including heavy metals.

show abstract

“…To support the latter hypothesis, Lestaevel and collaborators have previously demonstrated that U exposure from birth alters oxidative stress responses, metabolism of acetylcholine pathways as well as the metabolite profile in the cerebrospinal fluid in animals with impairment of neurobehavioral function [5,6,20]. …”

Section: Discussionmentioning

confidence: 99%

“…The central nervous system (CNS) is a target organ for many heavy metals and several reports have described neurological and neurobehavioral effects following internal exposure to U (for a review, see [4]), and more specifically during development. Briefly, U exposure from birth impairs object recognition and memory, causes anxiety and depressive-like behavior in adulthood and disturbs the balance of pro/antioxidant systems [5] and the cholinergic pathway [6]. Studies of animal models show that parental exposure to U during gestation and lactation impairs behaviors such as learning, activity, exploration, and emotionality in offspring [7,8,9].…”

Section: Introductionmentioning

confidence: 99%

Chronic Exposure to Uranium from Gestation: Effects on Behavior and Neurogenesis in Adulthood

Dinocourt

Culeux

Legrand

et al. 2017

IJERPH

Self Cite

View full text Add to dashboard Cite

Uranium exposure leads to cerebral dysfunction involving for instance biochemical, neurochemical and neurobehavioral effects. Most studies have focused on mechanisms in uranium-exposed adult animals. However, recent data on developing animals have shown that the developing brain is also sensitive to uranium. Models of uranium exposure during brain development highlight the need to improve our understanding of the effects of uranium. In a model in which uranium exposure began from the first day of gestation, we studied the neurobehavioral consequences as well as the progression of hippocampal neurogenesis in animals from dams exposed to uranium. Our results show that 2-month-old rats exposed to uranium from gestational day 1 displayed deficits in special memory and a prominent depressive-like phenotype. Cell proliferation was not disturbed in these animals, as shown by 5-bromo-2′deoxyuridine (BrdU)/neuronal specific nuclear protein (NeuN) immunostaining in the dentate gyrus. However, in some animals, the pyramidal cell layer was dispersed in the CA3 region. From our previous results with the same model, the hypothesis of alterations of neurogenesis at prior stages of development is worth considering, but is probably not the only one. Therefore, further investigations are needed to correlate cerebral dysfunction and its underlying mechanistic pathways.

show abstract

Cerebral cortex and hippocampus respond differently after post-natal exposure to uranium

Cited by 11 publications

References 42 publications

Uranium modifies or not behavior and antioxidant status in the hippocampus of rats exposed since birth

Uranium modifies or not behavior and antioxidant status in the hippocampus of rats exposed since birth

Toxicology of organic-inorganic hybrid molecules: bio-organometallics and its toxicology

Chronic Exposure to Uranium from Gestation: Effects on Behavior and Neurogenesis in Adulthood

Contact Info

Product

Resources

About