Cerebral Metabolism During Electrically Induced Seizures in Man

Posner, Jerome B.; Plum, Fred; Poznak, Alan Van

doi:10.1001/archneur.1969.00480100064010

Cited by 125 publications

(31 citation statements)

References 17 publications

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“…Subsequently, other researchers, utilizing a variety of techniques, replicated the finding of decreased postictal CBF and CMR from several minutes [Brodersen et al, 1973] to several days [Wilson et al, 1952] after ECT. These findings of postictal decreases were in sharp contrast with the few studies that found increased CBF or CMR during the ECT seizure itself [Posner et al, 1969;Bolwig et al, 1977b].…”

Section: Methodological Issuescontrasting

confidence: 99%

Structural and functional neuroimaging of electroconvulsive therapy and transcranial magnetic stimulation

Nobler

Tenebäck

Nahas

et al. 2000

Depression and Anxiety

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Neuroimaging has long been utilized to provide a measure of the effects of electroconvulsive therapy (ECT) on brain structure and function as well as to better understand its mechanisms of action. In a similar fashion, functional neuroimaging may provide the means to elucidate both the underlying neurobiological effects and therapeutic potential of transcranial magnetic stimulation (TMS). This article will review findings of neuroimaging studies of both TMS and ECT, concentrating on how such studies may help guide treatment. Depression and Anxiety 12:144–156, 2000. © 2000 Wiley‐Liss, Inc.

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Section: Methodological Issuescontrasting

confidence: 99%

Structural and functional neuroimaging of electroconvulsive therapy and transcranial magnetic stimulation

Nobler

Tenebäck

Nahas

et al. 2000

Depression and Anxiety

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“…Decreases, however, were often not accompanied by increases in neighboring regions (e.g., the right parietal decreases during the language tasks or the left frontal decreases during the nonlanguage tasks). Similarly, the present decreases occurred in the absence of any evidence for corresponding increases in cortex that generalized over tasks (Reivich, 1964) but also the capacity of the systemic circulation to support a large change in the circulatory demands of the brain by increasing cardiac output, manyfold if necessary, and increase peripheral resistence (Plum, 1968;Posner, 1969). The changes in brain blood flow during cognitive activation experiments are usually in the range of 10% or less, hardly a serious physiologic challenge to the normal brain vasculature.…”

Section: Blood Flow Decreases Caused By Redistribution Of the Blood Smentioning

confidence: 66%

Common Blood Flow Changes across Visual Tasks: II. Decreases in Cerebral Cortex

Shulman¹,

Fiez²,

Corbetta³

et al. 1997

Journal of Cognitive Neuroscience

1,770

112

1,473

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Experiments involving language-related processes tended to show larger decreases than nonlanguage experiments. This trend mainly reflected blood flow increases at certain areas in the passive conditions of the language experiments (relative to a fixation control in which no task stimulus was present) and slight blood flow decreases in the passive conditions of the nonlanguage experiments. When the active tasks were referenced to the fixation condition, the overall size of blood flow decreases in language and nonlanguage tasks were the same,

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“…Even in patients with cardiac complications under control like hypertension, angina, old infarction, heart failure and arrhythmias (19) , ECT remains essentially a safe procedure as long as decompensating factors like excessive sympathetic stimulation, hypoxia, hypercapnia, acidosis and electrolyte disturbance are avoided. Profound increase in cerebral blood flow and rise in intracranial pressure makes ECT dangerous in patients with pre-existing elevated intracranial pressure due to space occupying lesions (28) . During ECT, complications can occur at any stage during induction, during the application of electric current or recovery.…”

Section: Complicationsmentioning

confidence: 99%

Comparison of the haemodynamic effects and seizure activity during modified ECT with thiopentone and propofol used as inducing agents.

Premendran¹

2012

iosrphr

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Abstract:--Electroconvulsive therapy is also known as Electroshock or Shock therapy or Electroplex.Seizure activity produced by ECT is considered as the therapeutic aspect of this form of treatment, but is accompanied by untoward physiologic consequences, mainly cardiovascular and cerebral in nature. The hemodynamic effects can have a significant impact in patients with underlying cardiovascular disease.The effects of certain anesthetic agents may render seizure activity difficult to generate,and the unmodified physiologic consequences of treatment may be harmful. At the present time, a number of medications have been used during ECT including pretreatment sedation, anaesthetic agents, muscle relaxants, anticholinergics, and drugs to attenuate parasympathetic and sympathetic responses. This single blinded study was carried out on 100 adult patients equally divided into two groups of 50 each to compare the Hemodynamic effects and seizure activity of thiopentone sodium (GroupT) and propofol(Group P) when used as inducing agents in patients undergoing modified electroconvulsive therapy (MECT). Results showed propofol maintained significantly better haemodynamics compared to thiopentone and seizure time was significantly lower with propofol compared to thiopentone with equal theurapeutic effect and comparable complication rate of MECT. Recovery from anaesthesia post MECT was significantly quicker with propofol compared with thiopentone. Hence,we conclude that from anaesthesiologist's point of view propofol has advantage over thiopentone when used as an induction agent for modified ECT due to its favorable haemodynamics and early recovery characteristics.

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Cerebral Metabolism During Electrically Induced Seizures in Man

Cited by 125 publications

References 17 publications

Structural and functional neuroimaging of electroconvulsive therapy and transcranial magnetic stimulation

Structural and functional neuroimaging of electroconvulsive therapy and transcranial magnetic stimulation

Common Blood Flow Changes across Visual Tasks: II. Decreases in Cerebral Cortex

Comparison of the haemodynamic effects and seizure activity during modified ECT with thiopentone and propofol used as inducing agents.

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