Cerebral microbleeds: a guide to detection and clinical relevance in different disease settings

Charidimou, Andreas; Krishnan, Anant; Werring, David J.; Jäger, Hans Rolf

doi:10.1007/s00234-013-1175-4

Cited by 77 publications

(73 citation statements)

References 134 publications

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“…Our computational assessment is not exempt of errors. What computationally is identified as small, circular, T2*W hypointense foci does not always represent a microbleed and could alternatively be a vessel calcification, which can strongly mimic the microbleeds’ appearance (Charidimou, Krishnan, Werring, & Rolf Jager, 2013). On the other hand, microbleeds assessment could be inaccurate when these appear pale or in a position susceptible to partial volume effects (Cordonnier et al., 2007).…”

Section: Discussionmentioning

confidence: 99%

“…For example, both Alzheimer's disease and intracerebral hemorrhage are known to be associated with the presence and prevalence of brain microbleeds (Charidimou et al., 2013), as well as aging and hypertension. Whereas cerebral amyloid angiopathy pathology is said to be more likely to be associated with a lobar distribution of microbleeds; hypertension and lipohyalinosis, both related to SVD, are said to be more likely to be associated with brain microbleeds in the deep structures (e.g., basal ganglia).…”

Section: Discussionmentioning

confidence: 99%

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Interhemispheric characterization of small vessel disease imaging markers after subcortical infarct

et al. 2016

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BackgroundIn structural Magnetic Resonance Imaging (MRI) of patients with a recent small subcortical infarct (RSSI) and small vessel disease (SVD) imaging markers coexist. However, their spatial distribution and prevalence with respect to the hemisphere of the RSSI remain unknown.Materials and MethodsFrom brain MRI in 187 patients with an acute lacunar ischemic stroke clinical syndrome and a relevant diffusion weighted imaging (DWI)‐positive lesion, we semiautomatically extracted the RSSI, microbleeds, lacunes, old cortical infarcts, and white matter hyperintensities (WMH) using optimized thresholding in the relevant sequences, and rated the load of perivascular spaces. We registered all images to an age‐relevant brain template and calculated the probability distribution of all SVD markers mentioned for patients who had the RSSI in each hemisphere separately. We used the Wilcoxon and chi‐squared tests to compare the volumes and frequencies of occurrence, respectively, of the SVD markers between hemispheres throughout the sample.ResultsFifty‐two percent patients (n = 97) had the RSSI in the left hemisphere, 42% (n = 78) in the right, 2.7% (n = 5) in both, and 3.7% (n = 7) in the cerebellum or brainstem. There was no significant difference in RSSI frequency between left and right hemispheres (p = .10) in the sample. The median volume of the RSSI (expressed as a percentage of the total intracranial volume) was 0.05% (IQR = 0.06). There was no difference in median percent volume of the right RSSIs versus left (p = .16). Neither was there a significant interhemispheric difference in the volume of any of the SVD markers regardless of the location of the RSSI and they were equally distributed in both hemispheres.ConclusionAssessment of SVD imaging markers in the contralateral hemisphere could be used as a proxy for the SVD load in the whole brain to avoid contamination by the RSSI of the measurements, especially of WMH.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Interhemispheric characterization of small vessel disease imaging markers after subcortical infarct

et al. 2016

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“…Cerebral microbleeds (MBs) are known as the clinical manifestations of small-vessel disease, similar to lacunar infarctions and white matter lesions (1), and they are detected by small rounded, homogeneous regions of hypointensity on T2*-weighted gradient-recalled echo (T2*-GRE) magnetic resonance imaging (MRI), 3D T2*-weighted MR angiography (SWAN), or susceptibility-weighted imaging (SWI) (2).…”

Section: Introductionmentioning

confidence: 99%

Analysis of Cerebral Lobar Microbleeds and a Decreased Cerebral Blood Flow in a Memory Clinic Setting

et al. 2015

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Objective Cerebral microbleeds (MBs) have been previously associated with cognitive dysfunction, including Alzheimer's disease. In the present study, we aimed to clarify the relationship between cerebral lobar MBs and the regional cerebral blood flow (CBF). Methods We investigated the data obtained from 122 patients in our memory clinic who were examined by both MRI and 99m Tc-ethyl cysteinate dimer (ECD)-single photon emission computed tomography (SPECT). Patient brain scans were superimposed and brain regions containing both decreased CBF and MBs were visually identified. For each patient eight brain regions were evaluated, comprising the right and left frontal, temporal, parietal, and occipital lobes. Results Cerebral MBs were detected in 36 of the 122 (29.5%) patients. Of these 36 patients, 23 had detectable lobar MBs, which were primarily distributed in the occipital lobe in 19 of the 46 (41.3%) regions with lobar MBs. The frequency of MBs accompanied by a decreased CBF in the parietal and occipital lobes was significantly higher than that observed in the frontal lobe (73.3% vs. 27.3%, p<0.05, and 73.7% vs. 27.3%, p <0.05, respectively). Additionally, a decreased CBF was observed significantly more frequently in the brain regions with 5 or more MBs compared to the regions with one microbleed (83.3 vs. 25.0%, p<0.0005). Among the 17 patients with observable MBs accompanied by a decreased CBF, none were initially diagnosed with either subjective complaints or mild cognitive impairment. Conclusion We determined that the cerebral lobar MBs located in the parietal and occipital lobes, and the lobar regions with a large number of MBs, were significantly more likely to be accompanied by a decreased CBF.

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“…Classification according to the current definitions. 6,7 Response to "Cognitive function, cerebral microbleeds, radiotherapy, and bevacizumab in survivors of paediatric brain tumors"…”

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confidence: 99%

Cognitive function, cerebral microbleeds, radiotherapy, and bevacizumab in survivors of pediatric brain tumors

Passos¹,

Nzwalo

Marques³

et al. 2017

Neuro-Oncology

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Cerebral microbleeds: a guide to detection and clinical relevance in different disease settings

Cited by 77 publications

References 134 publications

Interhemispheric characterization of small vessel disease imaging markers after subcortical infarct

Interhemispheric characterization of small vessel disease imaging markers after subcortical infarct

Analysis of Cerebral Lobar Microbleeds and a Decreased Cerebral Blood Flow in a Memory Clinic Setting

Cognitive function, cerebral microbleeds, radiotherapy, and bevacizumab in survivors of pediatric brain tumors

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