Cerebral microdialysis as a new tool for neurometabolic monitoring

Peerdeman, Saskia M.; Girbes, Armand R. J.

doi:10.1007/s001340051230

Cited by 53 publications

(18 citation statements)

References 63 publications

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“…Extensive research has shown that the LPR is a good indicator of ischemic and hypoxic conditions as well as possible mitochondrial damage. 5,7,8,11,12 Under anaerobic conditions, the PBTO 2 and glucose level decrease while the LPR increases. 8,9 Elevated glycerol levels also indicate failure in cellular bioenergetics.…”

Section: Metabolic Trends Of Microdialysis Markersmentioning

confidence: 99%

“…Glycerol levels increase when cells do not have sufficient energy to maintain homeostasis. 11,12 Because of a lack of ATP, calcium ion channels can no longer be maintained, and cellular influx of calcium occurs. The influx activates phospholipases, causing the phospholipids within cellular membranes to be enzymatically cleaved, yielding abnormally high glycerol levels.…”

Section: Metabolic Trends Of Microdialysis Markersmentioning

confidence: 99%

“…This technique was refined to its present-day form in the 1970s by Tossman and Ungerstedt. 7,11 Microdialysis involves a catheter with a 10-mm semipermeable distalend membrane that is placed into the brain parenchyma. The catheter is pumped with fluid isotonic to tissue interstitium.…”

Section: Microdialysis Technologymentioning

confidence: 99%

See 2 more Smart Citations

Traumatic Brain Injury: Advanced Multimodal Neuromonitoring From Theory to Clinical Practice

Cecil¹,

Chen²,

Callaway³

et al. 2010

Critical Care Nurse

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Section: Metabolic Trends Of Microdialysis Markersmentioning

confidence: 99%

Section: Metabolic Trends Of Microdialysis Markersmentioning

confidence: 99%

See 1 more Smart Citation

Traumatic Brain Injury: Advanced Multimodal Neuromonitoring From Theory to Clinical Practice

Cecil¹,

Chen²,

Callaway³

et al. 2010

Critical Care Nurse

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“…Intracerebral microdialysis reflects only the metabolic disturbances and neurochemical changes in that particular part of the brain where the probe is placed.As measurements can easily be confounded by local areas of ischemia or contusion, results must be interpreted carefully [7]. The samples taken in our study originate from relatively normal brain tissue as catheter location was confirmed by CT.…”

Section: Discussionmentioning

confidence: 99%

Changes in cerebral glycolytic activity during transport of critically ill neurotrauma patients measured with microdialysis

Peerdeman

Girbes

2002

J Neurol

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Critically ill ventilated head injured patients often undergo in-hospital transports for diagnostic purposes. This transport is associated with an increased rate of complications. Secondary adverse events can occur, even in optimal conditions. We describe four patients in whom continuous cerebral microdialysis was performed during transportation to and from the CT Department. An increase in lactate/pyruvate ratio, glucose concentration and glutamate concentration was found, suggesting increased metabolic demand and relative or absolute impaired oxygen delivery. This occurred whilst all other measures, which are normally considered optimal for monitoring oxygen saturation and hemodynamics, showed no significant changes.

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“…In the extracellular fluid (ECF), liquid found between the cells containing proteins and electrolytes, profound disturbances have been demonstrated in concentrations of glutamate and aspartate and energy-related metabolites such as lactate, pyruvate, adenosine, inosine and hypoxanthine after brain injury and these changes correlate with the severity of the injury [2,6,29,31,[33][34][35].…”

Section: Methodsmentioning

confidence: 99%

Cerebral microdialysis of interleukin (IL)-1ß and IL-6: extraction efficiency and production in the acute phase after severe traumatic brain injury in rats

Folkersma

Brevé

Tilders

et al. 2008

Acta Neurochir (Wien)

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Background As a research tool, cerebral microdialysis might be a useful technique in monitoring the release of cytokines into the extracellular fluid (ECF) following traumatic brain injury (TBI). We established extraction efficiency of Interleukin(IL)-1ß and Interleukin(IL)-6 by an in vitro microdialysis-perfusion system, followed by in vivo determination of the temporal profile of extracellular fluid cytokines after severe TBI in rats. Materials and methodsIn vitro experiments using a polyether sulfon (PES) microdialysis probe especially developed for recovery of macromolecules such as cytokines, were carried out to establish the extraction efficiency of IL-1ß and IL-6 from artificial cerebrospinal fluid (CSF) with defined IL-1ß and IL-6 concentrations. In vivo experiments in which rats were subjected to TBI or sham and microdialysis samples were collected from the parietal lobe for measurement of cytokines. Findings The extraction efficiency was maximal 6.05% (range, 5.97-6.13%) at 0.5 µl/min −1 and decreased at higher flow rates. Both cytokines were detectable in the dialysates. Highest IL-1ß levels were found within 200 min, highest IL-6 concentrations were detected at later intervals (200-400 min). No differences were found between the TBI and control groups. Conclusions Cerebral microdialysis allows measurement of cytokine secretion in the ECF of brain tissue in rats.

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Cerebral microdialysis as a new tool for neurometabolic monitoring

Cited by 53 publications

References 63 publications

Traumatic Brain Injury: Advanced Multimodal Neuromonitoring From Theory to Clinical Practice

Traumatic Brain Injury: Advanced Multimodal Neuromonitoring From Theory to Clinical Practice

Changes in cerebral glycolytic activity during transport of critically ill neurotrauma patients measured with microdialysis

Cerebral microdialysis of interleukin (IL)-1ß and IL-6: extraction efficiency and production in the acute phase after severe traumatic brain injury in rats

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