Cerebral palsy and epilepsy

Knezevic-Pogancev, Marija

doi:10.2298/mpns1008527k

Cited by 10 publications

(8 citation statements)

References 15 publications

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“…The age of onset of epilepsy was frequently analyzed in various studies that have concluded that this is often under the age of one year, and that the earlier the onset of seizures is, the more severe forms of epilepsy will develop [8,20,21]. In our study we identified a high percentage of drug resistant forms of epilepsy (30.8%), nearly half of them (46.4%) being associated with quadriplegia.…”

Section: Discussionmentioning

confidence: 60%

Predictive Factors in the Onset of Epilepsy in Children with Cerebral Palsy

Anamaria

Sin

Micheu

et al. 2015

Acta Medica Marisiensis

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Objectives: the aim of the study was to identify predictive risk factors of the development of epilepsy in patients with cerebral palsy (CP).Materials and methods: We performed a bidirectional study in wich 177 patients diagnosed with CP with and without epilepsy have been selected for characteristics and risk factor comparison. We analyzed the history related to pregnancy and birth, gestational age, birth weight, fetal distress, the presence of neonatal convulsion, age of onset for the epilepsy, associated types of seizures, the response to anticonvulsant therapy and brain changes identified by Computer tomography and Magnetic resonance imaging examination.Results: epilepsy was found in 91 (51.4%) patients, most frequently in quadriplegic form (76.2% vs 23.8%), OR:3.04, 95% CI:1.42-6.52, p-0.005. In this group, the most common were partial seizures (34.4%), epileptic encephalopathy like Lennox Gastaut and West type (62.5%), and also neonatal seizures. Eighty percent of on-term infants with neonatal seizures later developed epilepsy. Factors like fetal distress, low birth weight, cytomegalovirus infection, history of pathological pregnancy were associated with an increased risk of developing epilepsy. Imaging change, especially cerebral atrophy had the highest frequency (37.5% vs 16%) in pacients with epilepsy. 28 (30.8%) patients had resistance epilepsy, 13 (46.4%) of them having quadriplegia. Early onset of epilepsy constitutes a sign of severity of epileptic forms (OR:3.09, 95% CI:1.187-8.061, p-0.01).Conclusions: The data are consistent with those in literature but is necessary following this study to clarify and support the assumption on preddictive factors and prognosis of epilepsy in this population.

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Section: Discussionmentioning

confidence: 60%

Predictive Factors in the Onset of Epilepsy in Children with Cerebral Palsy

Anamaria

Sin

Micheu

et al. 2015

Acta Medica Marisiensis

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“…It has been found that 15-60% of children with CP are affected with epilepsy [22]. Such patients suffer frequent attacks of epileptic seizures like generalized tonic clonic, myoclonic/ atonic, partial seizures and few of them also are victims of other epileptic associated syndromes viz infantile spasms, west and lennox-gastaut syndrome [23,24]. Though seizures can be controlled by pharmacotherapy, but epilepsy still remains an area of concern as epilepsy in patients with CP is of severe nature and difficult to control.…”

Section: Discussionmentioning

confidence: 99%

Improved Epilepsy and Speech Outcomes with Human Embryonic Stem Cell Therapy in Children with Cerebral Palsy

Shroff¹

2016

Int Arch Med

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Introduction: Cerebral Palsy (CP) is a group of permanent neurological disorders which is prevalent in children of neonatal age and is often associated with epilepsy and speech disorders. The various conventional treatments and therapies available so far are unable to treat these comorbidities. In this study, we aimed to evaluate 101 patients with CP having speech disorders and epilepsy. The patients were treated using human embryonic stem cells (hESC) therapy and assessed by Gross Motor Function Classification System-Expanded and Revised (GMFCS-E & R) score. Materials and Methods: Patients were given hESCs via different routes of administration for duration of 8 weeks and evaluated before and after the treatment on the basis of their levels of gross and motor function of improvement, i.e., frequency of the epileptic attacks and ability to speak. Single photon emission computed tomography (SPECT) scan investigations were also performed to support the studies. Results: There was an improvement in 96.61% of the epileptic patients and 91.39% of the patients with speech disorder. Of 59 patients affected with epilepsy, 18 patients had shown complete disappearance of epileptic episodes; and of 93 patients affected with speech, 27 patients became completely verbal. Conclusion: Hence, hESC therapy might be beneficial in patients with CP having epilepsy and speech disorders.

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“…CP is also associated with a higher incidence of seizures. The most frequent seizure types are complex focal and secondary generalized seizures, for which an early evaluation is strongly recommended [ 2 ] as children with CP tend to have an earlier epilepsy onset, and the degree of severity is positively correlated with the CPs severity.…”

Section: Introductionmentioning

confidence: 99%

“…Intellectual disabilities constitute a unique difficulty for epilepsy in children with CP. Typically, these children cannot describe epileptic events, parents describe them with apprehension, and epilepsy specialists rarely witness them [ 2 ]. The clinical course is not well defined, although epilepsy occurs in up to 90% of children with CP [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

Prediction Model for Identifying Factors Associated with Epilepsy in Children with Cerebral Palsy

et al. 2022

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(1) Background: Cerebral palsy (CP) is associated with a higher incidence of epileptic seizures. This study uses a prediction model to identify the factors associated with epilepsy in children with CP. (2) Methods: This is a retrospective longitudinal study of the clinical characteristics of 102 children with CP. In the study, there were 58 males and 44 females, 65 inpatients and 37 outpatients, 72 had epilepsy, and 22 had intractable epilepsy. The mean age was 16.6 ± 1.2 years, and the age range for this study was 12–18 years. Data were collected on the CP etiology, diagnosis, type of epilepsy and spasticity, clinical history, communication abilities, behaviors, intellectual disability, motor function, and feeding abilities from 2005 to 2020. A prediction model, Epi-PredictMed, was implemented to forecast the factors associated with epilepsy. We used the guidelines of “Transparent Reporting of a multivariable prediction model for Individual Prognosis or Diagnosis” (TRIPOD). (3) Results: CP etiology [(prenatal > perinatal > postnatal causes) p = 0.036], scoliosis (p = 0.048), communication (p = 0.018), feeding disorders (p = 0.002), poor motor function (p < 0.001), intellectual disabilities (p = 0.007), and the type of spasticity [(quadriplegia/triplegia > diplegia > hemiplegia), p = 0.002)] were associated with having epilepsy. The model scored an average of 82% for accuracy, sensitivity, and specificity. (4) Conclusion: Prenatal CP etiology, spasticity, scoliosis, severe intellectual disabilities, poor motor skills, and communication and feeding disorders were associated with epilepsy in children with CP. To implement preventive and/or management measures, caregivers and families of children with CP and epilepsy should be aware of the likelihood that these children will develop these conditions.

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Cerebral palsy and epilepsy

Abstract: The objective of the paper was to show the relationship between cerebral palsy and epilepsy and to determine the occurrence, associated factors, nature and prognosis of epilepsy in children with cerebral palsy.

Cited by 10 publications

References 15 publications

Predictive Factors in the Onset of Epilepsy in Children with Cerebral Palsy

Predictive Factors in the Onset of Epilepsy in Children with Cerebral Palsy

Improved Epilepsy and Speech Outcomes with Human Embryonic Stem Cell Therapy in Children with Cerebral Palsy

Prediction Model for Identifying Factors Associated with Epilepsy in Children with Cerebral Palsy

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