Cerebral palsy with autism and ADHD: time to pay attention

Gécz, Jozef; Berry, Jesia G.

doi:10.1111/dmcn.14773

Cited by 7 publications

(5 citation statements)

References 5 publications

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“…While the SFARI genes circularly depend on the ADOS and the DSM behavioral Autism criteria (i.e., they were obtained precisely based on those clinical inventories describing presumed socially inappropriate behaviors), the latter genes come from the disease-association network (the DisGeNET portal) which did not rely on an Autism diagnosis. These individuals are likely to receive an Autism diagnosis at present, because of the shifts and broadening of the criteria [23,24,[37][38][39][40][41]. However, they have their own clinical definition and known genetic origins [19,42].…”

Section: Methodsmentioning

confidence: 99%

Precision Autism: Genomic Stratification of Disorders Making Up the Broad Spectrum May Demystify Its “Epidemic Rates”

Torres

2021

JPM

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In the last decade, Autism has broadened and often shifted its diagnostics criteria, allowing several neuropsychiatric and neurological disorders of known etiology. This has resulted in a highly heterogeneous spectrum with apparent exponential rates in prevalence. I ask if it is possible to leverage existing genetic information about those disorders making up Autism today and use it to stratify this spectrum. To that end, I combine genes linked to Autism in the SFARI database and genomic information from the DisGeNET portal on 25 diseases, inclusive of non-neurological ones. I use the GTEx data on genes’ expression on 54 human tissues and ask if there are overlapping genes across those associated to these diseases and those from SFARI-Autism. I find a compact set of genes across all brain-disorders which express highly in tissues fundamental for somatic-sensory-motor function, self-regulation, memory, and cognition. Then, I offer a new stratification that provides a distance-based orderly clustering into possible Autism subtypes, amenable to design personalized targeted therapies within the framework of Precision Medicine. I conclude that viewing Autism through this physiological (Precision) lens, rather than viewing it exclusively from a psychological behavioral construct, may make it a more manageable condition and dispel the Autism epidemic myth.

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Section: Methodsmentioning

confidence: 99%

Precision Autism: Genomic Stratification of Disorders Making Up the Broad Spectrum May Demystify Its “Epidemic Rates”

Torres

2021

JPM

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“… 16 The increased risk was seen after both perinatal and childhood stroke, which is in line with the study by Williams et al 10 Other studies 9 , 11 did not distinguish between perinatal and childhood strokes. Epilepsy and adverse motor outcomes have been associated with ADHD in the general population 21 , 40 and are common sequelae after pediatric stroke. 41 , 42 Therefore, we also ran sensitivity analyses that censored individuals with these comorbidities.…”

Section: Discussionmentioning

confidence: 99%

“…Epilepsy and adverse motor outcomes have been associated with ADHD in the general population 21,40 and are common sequelae after pediatric stroke. 41,42 Therefore, we also ran sensitivity analyses that censored individuals with these comorbidities.…”

Section: Discussionmentioning

confidence: 99%

Association of Perinatal and Childhood Ischemic Stroke With Attention-Deficit/Hyperactivity Disorder

et al. 2022

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Key Points Question Does the risk of attention-deficit/hyperactivity disorder (ADHD) increase after pediatric stroke, and is that risk associated with family history of ADHD, adverse motor outcomes, or comorbid epilepsy? Findings This nationwide cohort study of 1320 patients who had perinatal or childhood stroke and 13 141 matched controls found a 2-fold increased risk of ADHD after stroke. Development of adverse motor outcomes and/or epilepsy were associated with a further elevated risk in children with perinatal stroke. Meaning These findings suggest that children may face an increased risk of ADHD after stroke and that surveillance for ADHD should be considered by pediatricians performing follow-up of children with pediatric stroke.

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“…While the SFARI genes circularly depend on the ADOS and the DSM behavioral Autism criteria (i.e., they were obtained precisely based on those clinical inventories describing presumed socially inappropriate behaviors), the latter genes come from the disease-association network (the DisGeNet portal) which did not rely on an Autism diagnosis. These individuals are likely to receive an Autism diagnosis at present, because of the shifts and broadening of the criteria [23,24,[38][39][40][41][42]. However, they have their own clinical definition and known genetic origins [19,43].…”

Section: Methodsmentioning

confidence: 99%

Precision Autism: Genomic Stratification of Disorders Making Up the Broad Spectrum May Demystify its “Epidemic Rates”

Torres

2021

Preprint

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In the last decade, Autism has broadened and often shifted its diagnostics criteria, allowing several neuropsychiatric and neurological disorders of known etiology. This has resulted in a highly heterogeneous spectrum with apparent exponential rates in prevalence. We ask if it is possible to leverage existing genetic information about those disorders making up Autism today and use it to stratify this spectrum. To that end, we combine genes linked to Autism in the SFARI database and genomic information from the DisGeNet portal on 25 diseases, inclusive of non-neurological ones. We use the GTEx data on genes' expression on 54 human tissues and ask if there are overlapping genes across those associated to these diseases and those from Autism-SFARI. We find a compact set of genes across all brain-disorders which express highly in tissues fundamental for somatic-sensory-motor function, self-regulation, memory, and cognition. Then, we offer a new stratification that provides a distance-based orderly clustering into possible Autism subtypes, amenable to design personalized targeted therapies within the framework of Precision Medicine. We conclude that viewing Autism through this physiological (Precision) lens, rather than from a psychological behavioral construct, may make it a more manageable condition and dispel the Autism epidemic myth.

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Cerebral palsy with autism and ADHD: time to pay attention

Abstract: This commentary is on the original article by Påhlman et al. on pages 320–327 of this issue.

Cited by 7 publications

References 5 publications

Precision Autism: Genomic Stratification of Disorders Making Up the Broad Spectrum May Demystify Its “Epidemic Rates”

Precision Autism: Genomic Stratification of Disorders Making Up the Broad Spectrum May Demystify Its “Epidemic Rates”

Association of Perinatal and Childhood Ischemic Stroke With Attention-Deficit/Hyperactivity Disorder

Precision Autism: Genomic Stratification of Disorders Making Up the Broad Spectrum May Demystify its “Epidemic Rates”

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