Cerebral perfusion in relation to cognitive function and type 2 diabetes

Tiehuis, A.M.; Vincken, Koen L.; Berg, Esther van den; Hendrikse, Jeroen; Manschot, S.M.; Mali, Willem P.Th.M.; Kappelle, L. Jaap; Biessels, Geert Jan

doi:10.1007/s00125-008-1041-9

Cited by 67 publications

(61 citation statements)

References 25 publications

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“…The results did not reach an agreement yet. Some studies have reported decreased CBF in T2DM (Xia et al 2015; Novak et al 2006; Last et al 2007; Nagamachi et al 1994), while others did not observe CBF alteration in T2DM (Tiehuis et al 2008; Rusinek et al 2015; Novak et al 2011). Most of the studies reporting no CBF alteration in T2DM typically used large regions of interest (ROI) and/or did not adequately account for the potential risk factors.…”

Section: Discussionmentioning

confidence: 98%

“…ASL has been recently used to evaluate CBF in T2DM patients, however the reports are contradictory. Some studies found that resting CBF is similar between T2DM patients and controls (Tiehuis et al 2008; Rusinek et al 2015; Novak et al 2011), while others reported reduced CBF in patients with T2DM (Xia et al 2015; Novak et al 2006; Last et al 2007; Nagamachi et al 1994). The cross-sectional design of these studies however, did not allow to investigate the association between T2DM and changes in brain perfusion or structure and cognitive or mobility functions over time.…”

Section: Introductionmentioning

confidence: 99%

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The resting perfusion pattern associates with functional decline in type 2 diabetes

Dai

Duan

Alfaro

et al. 2017

Neurobiology of Aging

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We investigated the relationships between cerebral blood flow (CBF), cognitive and mobility decline in type 2 diabetes mellitus (T2DM) over a two-year period. Seventy-three participants (41 T2DM and 32 controls) were evaluated using volumetric CBF with arterial spin labeling (ASL) perfusion magnetic resonance imaging (pMRI) at baseline and at the two-year follow-up. Regions with significant CBF differences between T2DM participants and controls at baseline were detected using voxel-wise analysis. Correlation analysis was performed to investigate the association between regional CBF and cognitive or mobility performance over the two-year span. Compared to controls, participants with T2DM had decreased CBF in the resting state default mode, visual, and cerebellum networks. Greater decrease in longitudinal CBF values at these regions over a two-year span was associated with worse gait, memory and executive functions, and higher baseline insulin resistance and worse baseline cognitive performance. In T2DM, impairment of resting regional perfusion is closely related to worse cognitive and mobility performance. Insulin resistance may further contribute to regional perfusion deficit in T2DM.

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

The resting perfusion pattern associates with functional decline in type 2 diabetes

Dai

Duan

Alfaro

et al. 2017

Neurobiology of Aging

View full text Add to dashboard Cite

show abstract

“…Chronic exposure to hyperglycaemia may also lead to abnormalities in cerebral capillaries, such as basement membrane thickening [73,74]. Cerebral blood flow is reduced in experimental models of diabetes [75], but the effects of T2DM on cerebral perfusion in humans are less clear [76].…”

Section: Underlying Mechanismsmentioning

confidence: 99%

Caffeine, Diabetes, Cognition, and Dementia

Biessels

2010

JAD

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Abstract. People with diabetes mellitus are at increased risk of cognitive dysfunction. This review explores the relation between caffeine intake, diabetes, cognition and dementia, focusing on type 2 diabetes (T2DM). Epidemiological studies on caffeine/coffee intake and T2DM risk are reviewed. Next, the impact of T2DM on cognition is addressed. Finally, the potential for caffeine to modulate the risk of cognitive decline in the context of diabetes is explored. The conclusion is that, although epidemiological studies indicate that coffee/caffeine consumption is associated with a decreased risk of T2DM and possibly also with a decreased dementia risk, we can at present not be certain that these associations are causal. For now, recommendations for coffee consumption in individuals with T2DM or pre-diabetic stages are therefore difficult to establish, but it should be acknowledged that caffeine does appear to have several properties that warrant further investigations in this field.

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“…3 There are reports of changed cerebral blood flow in T2DM patients, 3 although a study with a larger sample found no significant differences when accounting for brain volume. 7 Recent studies examined the relation of cognition, brain volume, or white matter alterations with both cerebral blood flow and cerebrovascular reactivity and found no significant relationships. 8,9 Notably, a number of functional magnetic resonance imaging (fMRI) studies relied on BOLD (Blood Oxygenation Level-Dependent) signal 10 to indirectly measure neuronal activity and investigate neurophysiological impairment.…”

Section: Introductionmentioning

confidence: 99%

Early Disrupted Neurovascular Coupling and Changed Event Level Hemodynamic Response Function in Type 2 Diabetes: An fMRI Study

Duarte

Pereira

Quendera

et al. 2015

J Cereb Blood Flow Metab

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Type 2 diabetes (T2DM) patients develop vascular complications and have increased risk for neurophysiological impairment. Vascular pathophysiology may alter the blood flow regulation in cerebral microvasculature, affecting neurovascular coupling. Reduced fMRI signal can result from decreased neuronal activation or disrupted neurovascular coupling. The uncertainty about pathophysiological mechanisms (neurodegenerative, vascular, or both) underlying brain function impairments remains. In this cross-sectional study, we investigated if the hemodynamic response function (HRF) in lesion-free brains of patients is altered by measuring BOLD (Blood Oxygenation Level-Dependent) response to visual motion stimuli. We used a standard block design to examine the BOLD response and an event-related deconvolution approach. Importantly, the latter allowed for the first time to directly extract the true shape of HRF without any assumption and probe neurovascular coupling, using performance-matched stimuli. We discovered a change in HRF in early stages of diabetes. T2DM patients show significantly different fMRI response profiles. Our visual paradigm therefore demonstrated impaired neurovascular coupling in intact brain tissue. This implies that functional studies in T2DM require the definition of HRF, only achievable with deconvolution in event-related experiments. Further investigation of the mechanisms underlying impaired neurovascular coupling is needed to understand and potentially prevent the progression of brain function decrements in diabetes.

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Cerebral perfusion in relation to cognitive function and type 2 diabetes

Abstract: Aim/hypothesis Underlying mechanisms for decreased cognitive functioning in patients with type 2 diabetes are unclear. In the general population, cerebral hypoperfusion is a risk factor for cognitive dysfunction and dementia.

Cited by 67 publications

References 25 publications

The resting perfusion pattern associates with functional decline in type 2 diabetes

The resting perfusion pattern associates with functional decline in type 2 diabetes

Caffeine, Diabetes, Cognition, and Dementia

Early Disrupted Neurovascular Coupling and Changed Event Level Hemodynamic Response Function in Type 2 Diabetes: An fMRI Study

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