Cerebral plasticity and connectopathies: mechanisms of comorbidity of neurological diseases and depression

Gulyaeva, N. V.

doi:10.17116/jnevro2016116111157-162

Cited by 7 publications

(1 citation statement)

References 23 publications

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“…Подобная клиническая симптоматика появляется после проведения комплексного лечения и не связана с рецидивом основного заболевания или метастатическим поражением центральной нервной системы. Развитие данных проявлений связано как с прямым токсическим действием химио-и лучевой терапии, так и со стено-окклюзирующим процессом в подключичной артерии и ее ветвях, спазмированными лестничными мышцами и фиброзно-рубцовыми послеоперационными и постлучевыми изменениями на стороне оперативного вмешательства [6,11].…”

Section: неврология / Neurologyunclassified

Clinical and neuroimaging laboratory possibilities of diagnostics of vestibulo-atactic syndrome in patients with postmastectomic syndrome

Nikolaeva

Поспелова

Krasnikova

et al. 2023

Transl. med. (Print)

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Background. In recent years, the prognosis of survival after treatment for breast cancer (BC) has improved significantly, leading to an increase in the life expectancy of patients and the incidence of long-term side effects of therapy. reducing the risks of complications and developing a unified algorithm for diagnosing cerebral complications are necessary to improve the quality of life of patients.Objective. To correlate the CNS and endothelium damage biomarkers concentration and the functional connectivity of the brain in patients with newly diagnosed vestibulo-atactic syndrome (VAS) and without it in the late period of radical treatment of breast cancer.Design and methods. The study involved 21 patients with VAS in the late postoperative period after radical treatment of breast cancer, as well as a group of healthy volunteers — 17 people. Biomarkers were determined by ELISA. Functional MRI was performed.Results. An increase in markers of CNS damage and endothelial damage (ICAM, PECAM) was noted in patients with post-mastectomy syndrome (PMES) and VAS, compare with control group and PMES without VAS group. The processes of disorganization and the formation and strengthening of interand intrahemispheric connections were noted using fMRI.Conclusion. The development of novel diagnostics methods, including the use of fMRI and the determination of different biomarkers are promising for improvement of the VAS treatment effectiveness in patients with PMES.

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Section: неврология / Neurologyunclassified

Clinical and neuroimaging laboratory possibilities of diagnostics of vestibulo-atactic syndrome in patients with postmastectomic syndrome

Nikolaeva

Поспелова

Krasnikova

et al. 2023

Transl. med. (Print)

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Stress-Associated Molecular and Cellular Hippocampal Mechanisms Common for Epilepsy and Comorbid Depressive Disorders

Gulyaeva

2021

Biochemistry Moscow

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The review discusses molecular and cellular mechanisms common to the temporal lobe epileptogenesis/epilepsy and depressive disorders. Comorbid temporal lobe epilepsy and depression are associated with dysfunction of the hypothalamic-pituitary-adrenocortical axis. Excessive glucocorticoids disrupt the function and impair the structure of the hippocampus, a brain region key to learning, memory, and emotions. Selective vulnerability of the hippocampus to stress, mediated by the reception of glucocorticoid hormones secreted during stress, is the price of the high functional plasticity and pleiotropy of this limbic structure. Common molecular and cellular mechanisms include the dysfunction of glucocorticoid receptors, neurotransmitters, and neurotrophic factors, development of neuroinflammation, leading to neurodegeneration and loss of hippocampal neurons, as well as disturbances in neurogenesis in the subgranular neurogenic niche and formation of aberrant neural networks. These glucocorticoid-dependent processes underlie altered stress response and the development of chronic stress-induced comorbid pathologies, in particular, temporal lobe epilepsy and depressive disorders.

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Multi-Level Plasticity-Pathology Continuum of the Nervous System: Functional Aspects

Gulyaeva

2022

Neurochem. J.

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Cerebral plasticity and connectopathies: mechanisms of comorbidity of neurological diseases and depression

Cited by 7 publications

References 23 publications

Clinical and neuroimaging laboratory possibilities of diagnostics of vestibulo-atactic syndrome in patients with postmastectomic syndrome

Clinical and neuroimaging laboratory possibilities of diagnostics of vestibulo-atactic syndrome in patients with postmastectomic syndrome

Stress-Associated Molecular and Cellular Hippocampal Mechanisms Common for Epilepsy and Comorbid Depressive Disorders

Multi-Level Plasticity-Pathology Continuum of the Nervous System: Functional Aspects

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