Cerebral Proliferative Angiopathy: A Rare Type of Cerebral Vascular Malformation

Tse, JCH; Lee, TF; Lai, Beatrice Pui Yee; Luk, Sy; Leung, KW; Wc, Wong

doi:10.12809/hkjr1816833

Cited by 2 publications

(1 citation statement)

References 11 publications

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“…3 There are only few reports of CPA described from Asia. [4][5][6][7][8][9][10][11][12][13] Liu et al 13 had described 5 cases of CPA from China. A detailed review of case reports and case series with CPA was published by Nunes et al 14 The term 'proliferative' angiopathy, used to describe this rare AVM, is appropriate as there is a strong evidence of new blood vessels formation, which is uncommon in classical AVMs.…”

Section: Clinico-radiological Featuresmentioning

confidence: 99%

Clinico-radiological features of cerebral proliferative angiopathy: A large case series from India

Srivastava

Gandhi

Kumar³

2022

Neuroradiol J

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Background Based on angiographic features, a rare subgroup, different from classical brain AVMs, called cerebral proliferative angiopathy (CPA) was suggested by Lasjaunias et al. in 1989. There are only few reports of CPA described from Asia. Liu et al. has described 5 cases of CPA from China. The objective of study was to evaluate the clinico-radiological features of patients with CPA in our cohort and to find out the differences between our study and the study by Lasjaunias and Liu et al. Methods We retrospectively analysed cases of CPA from March 2012 to April 2020. All radiological images of the patients with AVMs were studied and findings suggestive of CPA were identified. We found 10 patients with CPA out of 272 cases of AVM (10/272) and described the various demographic and clinico-radiological features. Results The age of the patients with CPA in our series varied from 14 to 53 years and the mean age was 28.6 years. There was male preponderance (60%) with male to female ratio of 3:2. The most common presentation was seizure (70%). Intracranial haemorrhage was present in five patients. One patient had cerebral infarction. Conclusions There were substantial differences in clinico-radiological profile of patients with CPA in our cohort as compared to the study by Lasjaunias et al. and Liu et al. in form of male dominance, higher rate of ICH and seizure. In our knowledge, this is the second largest series of CPA worldwide and the first largest series in Asia.

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