Cerebral Small Vessel Disease and Kidney Function Predict Long-Term Survival in Patients With Acute Stroke

Abstract

Background and Purpose-Cerebral small vessel disease reflected by white matter lesions (WMLs) in MRI and kidney function reflected by estimated glomerular filtration rate (eGFR) is closely associated in patients without stroke. We studied whether eGFR and WMLs predict long-term survival in patients with acute stroke. Methods-After exclusion of patients with low eGFR (Nϭ5 [1.3%]; Ͻ30 mL/min/1.73 m 2 ), consecutive patients with acute stroke (Nϭ378) subjected to MRI and serum creatinine determination were included in the study and prospectively followed-up up to 12 years. Results-Of the patients, 71.2% had died during the follow-up, 152 (40.2%) had moderate (eGFR Ͻ60 mL/min/1.73 m

IV thrombolysis and renal function

“…19 Secondary outcome measures were unfavorable outcome (mRS scores [2][3][4][5][6] (if male and SCr $0.9 mg/dL). 21 In addition, we assessed the interaction of renal insufficiency and IVT treatment between patients treated with and without IVT.…”

Kidney Function and White Matter Disease in Young Stroke Patients

“…Associations between clinically significant impaired kidney function and WMH have been demonstrated in elderly patients with stroke. 13,22 Furthermore, in young patients with ischemic stroke, leukaraiosis and silent brain infarction were shown to be more frequent in those with kidney dysfunction. 7 Our findings now indicate a relationship between even moderately decreased kidney function and WMH reflecting small-vessel disease.…”

Educational History Is an Independent Predictor of Cognitive Deficits and Long-Term Survival in Postacute Patients With Mild to Moderate Ischemic Stroke

“…3,[24][25][26][27] A total of 642 patients fulfilled the inclusion criteria (ischemic stroke, age 55-85 years, living in Helsinki, speaking Finnish language) and were invited to a follow-up visit 3 months later. Of these, 71 died (11.1%) before the 3-month follow-up, 82 refused (12.8%), and 3 were lost (0.5%) because of undefined causes.…”