Cerebral Structure and Function in Stroke-free Patients with Atrial Fibrillation

Silva, Danilo S.; Caseli, Bruna G.; Campos, Brunno M.; Avelar, Wagner Mauad; Lino, Ana Paula Beppler Lazaro; Balthazar, Márcio Luiz Figueredo; Figueiredo, Marcio J.O.; Cendes, Fernando; Pegoraro, Luiz Fernando; Coan, Ana Carolina

doi:10.1016/j.jstrokecerebrovasdis.2021.105887

Cited by 4 publications

(1 citation statement)

References 30 publications

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“…AF has been associated with decreased volume in the right basal frontal lobe and right inferior cerebellum 64 , taking into account the existence of hypertension and a history of heart failure. There is growing evidence that the aging process, hypertension, and AF are all connected to structural and functional changes in various parts of the central nervous system 16 that affect autonomic control 65 .…”

Section: Discussionmentioning

confidence: 99%

The Link Between Atrial Fibrillation And Cognitive Impairment: A Systematic Review And Meta-Analysis

Agarwal,

Mostafa,

Ahmad

et al. 2023

Preprint

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Atrial fibrillation (AF) affects a substantial population of individuals aged ≥55 years globally and has been associated with an increased risk of cognitive impairment (CImp) due to the shared risk factors such as aging, obesity, and diabetes. It is essential to comprehend their unique relationship to manage them effectively to reduce its impact on public health systems. We performed a PubMed search of English language papers published till 31 May 2023. Data was extracted and effect measures were calculated. Meta-analysis of 33 studies revealed a significant association between AF and CImp after adjusting for comorbidities, with considerable between-study heterogeneity (pooled OR: 1.62; 95% CI: 1.43, 1.81, I2 = 94.143). Prospective and cross-sectional studies revealed substantial associations. CImp in AF may be mediated through silent brain infarctions, microemboli, brain atrophy, and inflammation. Future research should prioritize investigating the mechanisms and etiology of this association, as well as potential treatment options.

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Section: Discussionmentioning

confidence: 99%