Cerebral Venous Thrombosis as a Manifestation of Acute Ulcerative Colitis

Musio, Franco; Older, Steven A.; Jenkins, Terry R.; Gregorie, Erik M.

doi:10.1097/00000441-199301000-00006

Cited by 35 publications

(12 citation statements)

References 40 publications

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“…The increased risk of thromboembolism (TE) in patients with active IBD is well established [9][10][11][12][13] with a 6.5% incidence of thrombosis or a 3-4 fold higher risk than in the general population [14] . TE can also occur in the pediatric age group [15] .…”

Section: Discussionmentioning

confidence: 99%

Cerebral venous thrombosis and heparin-induced thrombocytopenia in an 18-year old male with severe ulcerative colitis

Thorsteinsson¹,

Magnussson²,

Hallberg³

et al. 2008

WJG

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T h e r i s k o f t h r o m b o e m b o l i s m i s i n c r e a s e d i n inflammatory bowel disease and its symptoms may be overlooked. Furthermore, its treatment can be complex and is not without complications. We describe a case of an adolescent boy who developed a cerebral sinus venous thrombosis during a relapse of his ulcerative colitis and who, while on treatment with heparin, developed heparin-induced thrombocytopenia (HIT). The treatment was then switched to fondaparinux, a synthetic and selective inhibitor of activated factor Ⅹ.

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Section: Discussionmentioning

confidence: 99%

Cerebral venous thrombosis and heparin-induced thrombocytopenia in an 18-year old male with severe ulcerative colitis

Thorsteinsson¹,

Magnussson²,

Hallberg³

et al. 2008

WJG

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“…During pregnancy or puerperium, a significant increase in the risk of cerebral venous thrombosis was associated with caesarian delivery (OR 3.1), increasing maternal age (OR 2.5), presence of comorbidities including hyperhemesis (OR 14.2), intercurrent infections (OR 3.45) and maternal hypertension [18] Neurosurgery [19] Meningitides [20] Arterovenous malformation [21] Sepsis (sinusitis, mastoiditis, cellulitis) [22,23] Stroke and hemorrhage Space-occupying lesions Jugular catheterization Systemic Dehydration (diabetic ketoacidosis) Septicemia [24] Pregnancy and puerperium [5] Inflammatory bowel disease [25] Malignancy [26] Sarcoidosis [27] Collagen disease (Behcet's syndrome, SLE, Sjögren's syndrome) [28][29][30] Homocysteinuria [31] Nephrotic syndrome [32] Autoimmune thyroiditis Drugs…”

Section: Etiologymentioning

confidence: 99%

Epidemiology of Cerebral Vein and Sinus Thrombosis

Agnelli

Verso²

2007

Handbook on Cerebral Venous Thrombosis

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Cerebral venous thrombosis is a serious but potentially treatable cerebrovascular disorder that, unlike arterial cerebrovascular disorder, often affects young adults and children. Cerebral venous thrombosis is a challenging condition for the clinicians because of the wide spectrum of its clinical presentation. Although recognized for more than 100 years, its incidence has been underestimated in the past due to the lack of accurate diagnostic techniques.

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“…3,15 Özellikle hastalığın aktif döneminde ortaya çıkan koagülasyon ve trombosit anormallikleri, trombositoz, artmış fibrinojen, Faktör V, Faktör VIII ve azalmış antitrombin III seviyeleri, azalmış trombosit agregasyonu, artmış tromboplastin yapımı ve fibrin mikroklotlarının varlığı tromboz oluşumundan sorumlu tutulmuş-tur. 16 Ayrıca, bu hastalarda aneminin varlığı ve dehidratasyon da tromboz için risk oluşturabil-mektedir.…”

Section: Discussionunclassified