Epidemiology of Cerebral Vein and Sinus Thrombosis

Agnelli, Giancarlo; Verso, Melina

doi:10.1159/000111258

Cited by 34 publications

(39 citation statements)

References 37 publications

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“…The observed frequency of CVST is slightly lower than that of peripartum and postpartum arterial stroke. 2,45,46 Recent clinical series and review studies 2,17,27,29,32,52,62 have confirmed the female predominance among patients suffering CVST, contrary to older reports postulating that males and females were equally affected. 44 The age group of patients demonstrating the highest frequency of CVST is those between 20 and 40 years of age.…”

Section: Incidence and Demographicsmentioning

confidence: 97%

“…In adults, the incidence of CVST has been estimated to be as high as 3-4 cases per million people, while the respective incidence in children and neonates is higher and has been estimated to be as many as 7 cases per million. 2,23,62 A pediatric multicenter study in the US showed that CVST affects predominantly children < 6 months old. 69 It has been reported that female sex repCerebral venous sinus thrombosis: review of the demographics, pathophysiology, current diagnosis, and treatment resents a predisposing factor for developing CVST.…”

Section: Incidence and Demographicsmentioning

confidence: 99%

“…32,62 This observation is probably related to conditions such as pregnancy, puerperium, and usage of oral contraceptives in the female population. 2,22 Twelve cases per 100,000 deliveries are complicated by peripartum and postpartum sinus thrombosis. The observed frequency of CVST is slightly lower than that of peripartum and postpartum arterial stroke.…”

Section: Incidence and Demographicsmentioning

confidence: 99%

“…17,21,29,62,68 The initial reports concerning CVST, which were based on autopsy series, led to the underestimation of the actual incidence of CVST. 2 More recently, the evolution of noninvasive diagnostic imaging methodologies such as CT angiography and venography, as well as MR imaging, angiography, and venography, 47,56,57 enriched our knowledge regarding the full clinical spectrum of CVST and provided us with a more accurate estimation of its true incidence. 2,8,11,62 The purpose of the current study is to review the pertinent literature concerning the most recent demographic data, current pathophysiological mechanisms, predisposing conditions, and the etiological factors to outline the recent advances in the early diagnosis and the prompt management of CVST.…”

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confidence: 99%

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Cerebral venous sinus thrombosis: review of the demographics, pathophysiology, current diagnosis, and treatment

Filippidis¹,

Kapsalaki

Patramani

et al. 2009

FOC

120

160

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Cerebral venous sinus thrombosis (CVST) is a rare clinicopathological entity. The incidence of CVST in children and neonates has been reported to be as high as 7 cases per million people, whereas in adults the incidence is 3–4 cases per million. The predisposing factors to this condition are mainly genetic and acquired prothrombotic states and infection. The clinical picture of CVST is nonspecific, highly variable, and can mimic several other clinical conditions. Diagnosis of CVST is established with the implementation of neuroimaging studies, especially MR imaging and venography. Identification and elimination of the underlying cause, anticoagulation, proper management of intracranial hypertension, and anticonvulsant prophylaxis constitute cornerstones of CVST treatment. Newer treatment strategies such as endovascular thrombolysis and decompressive craniectomy have been recently used in the treatment of patients with CVST with variable success rates. Further clinical research must be performed to delineate the exact role of these newer treatments in the management of severe cases of CVST. The recent advances in the diagnosis and treatment of patients with CVST have significantly lowered the associated mortality and morbidity and have improved the outcome of these patients.

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Section: Incidence and Demographicsmentioning

confidence: 97%

Section: Incidence and Demographicsmentioning

confidence: 99%

Section: Incidence and Demographicsmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Cerebral venous sinus thrombosis: review of the demographics, pathophysiology, current diagnosis, and treatment

Filippidis¹,

Kapsalaki

Patramani

et al. 2009

FOC

120

160

View full text Add to dashboard Cite

show abstract

“…Cerebral venous thrombosis (CVT) is a rare disorder with highly variable presentation that can complicate the recognition of this potentially fatal state [1][2][3]. Neuroimaging serves a critical role in the diagnosis of CVT and computed tomography (CT) is often the first imaging modality ordered; however, CT imaging of the head is not the most sensitive imaging technique, and in patients with hypercoagulable disorders, the threshold to order additional imaging studies should remain low when CVT is high on the differential diagnosis [4].…”

Section: Introductionmentioning

confidence: 99%

Initial Misdiagnosis of Cerebral Venous Thrombosis: A Case Report

Alluri¹

2013

J Med Cases

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Cerebral venous thrombosis (CVT) is a rare condition with an incidence ranging from 2 to 4 cases per million people per year. Its presentation is highly variable and can include headaches, changes in vision, focal neurological deficits, seizures and coma. Treatment of CVT remains controversial, particularly regarding long-term anticoagulation. We report a case of a 35-year-old Asian male with a history of anti-thrombin III deficiency that was not adequately anticoagulated. He presented with an acute and progressively worsening left-sided headache and ipsilateral ear fullness. The patient was initially misdiagnosed with a migraine headache after computed tomography (CT) of the head was interpreted as normal.

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Cerebral venous thrombosis in Behçet’s disease: a systematic review

2011

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Behçet's disease (BD) is a chronic inflammatory multisystem disorder which can involve the central nervous system (CNS). Cerebral venous thrombosis (CVT) is one of its major neurological manifestations. We aimed to review the epidemiologic and clinical features of CVT in patients with BD, as well as the available data on therapeutic interventions and prognosis. Systematic review of all observational studies of BD patients was done. Search strategy included electronic searches of MEDLINE (1966-August 2009). Occurrence of CVT in BD and Neuro-Behçet patients, occurrence of CVT as the inaugural manifestation of BD, clinical and neuro-imaging characteristics of CVT, prothrombotic evaluation, treatment options and prognosis were extracted. A meta-analysis of available results was performed when feasible. Twenty-three studies were included, with 290 cases of CVT in patients with BD. The incidence of CVT per 1,000 person-years was 3 (95% CI: 1-8), being higher in retrospective studies (3.2, 95% CI: 1-10) than in prospective studies (2.7, 95% CI: 1-13). Among patients with neurologic involvement, the incidence rate was 15.1/1,000 person-years. The onset was progressive in 77% of the patients. Intracranial hypertension syndrome was a frequent presentation of CVT in BD. The most frequent sites of occlusion were the superior sagittal and the transverse sinus. Most of the studies did not evaluate the prevalence of prothrombotic disorders. Treated CVT was associated with a good prognosis. CVT is a frequent neurological manifestation of BD. When treated, BD-associated CVT bears a good prognosis. There is insufficient information regarding the role of concomitant prothrombotic disorders and specific treatments.

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Epidemiology of Cerebral Vein and Sinus Thrombosis

Cited by 34 publications

References 37 publications

Cerebral venous sinus thrombosis: review of the demographics, pathophysiology, current diagnosis, and treatment

Cerebral venous sinus thrombosis: review of the demographics, pathophysiology, current diagnosis, and treatment

Initial Misdiagnosis of Cerebral Venous Thrombosis: A Case Report

Cerebral venous thrombosis in Behçet’s disease: a systematic review

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