Cerebral venous thrombosis: report of 2 cases of hemorrhagic venous infarction

Hoang, Thi Phuong Thao; Perazzini, Chiara; Ngo, Dac Hong An; Saby, Celine; Bendjelid, Si-M'Hamed; Boyer, L.

doi:10.1016/j.radcr.2020.05.009

Cited by 5 publications

(6 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…22 Guidelines in human medicine for diagnosing venous infarction include: infarction not conforming to a major arterial vascular territory, crossing the typical arterial boundaries, or extending over more than one arterial distribution; presence of multiple isolated lesions; involvement of subcortical regions with sparing of the cortex, or cortical-subcortical topography; often hemorrhagic component; proximity to a venous sinus. [24][25][26][27][28] The retrograde venous pressure caused by thrombosis severely reduces the cerebral blood flow through a vicious cycle of increased intracranial pressure, blood-brain barrier disruption with edema and hemorrhage, and reduced CSF drainage, leading to neuroparenchymal ischemia and necrosis. 23,26,29,30 The restricted diffusion in acute venous thrombosis suggests that cytotoxic edema is mainly responsible for the MRI changes, and that vasogenic edema follows but is not the primary pathological event.…”

Section: Discussionmentioning

confidence: 99%

MRI ischemic and hemorrhagic lesions in arterial and venous territories characterize central nervous system intravascular lymphoma in dogs

Mattei¹,

Oevermann

Schweizer

et al. 2022

Vet Radiology Ultrasound

View full text Add to dashboard Cite

Intravascular lymphoma (IVL) is characterized by the proliferation of large malignant lymphocytes within the lumen of blood vessels. This retrospective, multi-center, case series study aimed to describe the MRI features of confirmed central nervous system IVL in dogs and compare them with histopathological findings. Medical record databases from seven veterinary centers were searched for cases of histologically confirmed IVL. Dogs were included if an MRI was performed. The MRI studies and histopathology samples were reviewed to compare the MRI changes with the histopathological findings. Twelve dogs met the inclusion criteria (12 brains and three spinal cords). Imaging of the brains revealed multifocal T2-weighted/FLAIR hyperintense and T1-weighted iso-hypointense lesions, with variable contrast enhancement; areas of abnormal diffusion both in arterial and venous territories in diffusionweighted imaging; and meningeal enhancement. On gradient echo images (GRE), the changes comprised tubular susceptibility artifacts, consistent with the "susceptibility vessel sign", and additional variably sized/shaped intraparenchymal susceptibility 294

show abstract

Section: Discussionmentioning

confidence: 99%

MRI ischemic and hemorrhagic lesions in arterial and venous territories characterize central nervous system intravascular lymphoma in dogs

Mattei¹,

Oevermann

Schweizer

et al. 2022

Vet Radiology Ultrasound

View full text Add to dashboard Cite

show abstract

“…Neck pain and stiffness was reported in CVTinduced hemorrhagic venous infarction and acute subarachnoid hemorrhage. [30][31][32] In the CVT severity scale, neck discomfort was added as item 18.…”

Section: Discussionmentioning

confidence: 99%

Development and validation of a severity scale based on clinical manifestations for patients with cerebral venous thrombosis

Wang

Duan

et al. 2022

Preprint

View full text Add to dashboard Cite

Introduction : Cerebral venous thrombosis (CVT) is a rare subtype of stroke. However, existing scales were insufficient to evaluate the overall severity of CVT. The aim of this study is to develop and validate a CVT severity scale. Methods Items 1–11 were directly derived from NIHSS. New items were generated from a literature review and focus group discussion. 170 CVT patients were prospectively recruited from 26 top tertiary hospitals in China Mainland from January 2021 to May 2022 to validate the CVT severity scale. The CVT severity scale, NIHSS, mRS and GCS was rated at admission. The lumbar puncture opening pressure was also recorded. 20 randomly selected CVT patients were rated with the CVT severity scale again 24 hours later. The clinical outcome of CVT was evaluated by mRS at 6 months after baseline. Results We successfully established a CVT severity scale with 18 items. Exploratory factor analysis showed that 18 items were attributed to factor 1 (focal neurological deficits), factor 2 (diffuse encephalopathy), factor 3 (intracranial hypertension) and factor 4 (cavernous sinus syndrome). CVT severity scale was positively correlated with ICP, NIHSS and mRS, and negatively correlated with GCS at baseline. CVT severity scale > 3 or factor 3 > 2 indicated intracranial hypertension. CVT severity scale > 10 indicated poor clinical outcome at 6 months of follow-up. Meanwhile, CVT severity scale showed high internal consistency and test-retest reliability. Conclusions The CVT severity scale included 18 items encompassing 4 domains of focal neurological deficits, diffuse encephalopathy, IH and cavernous sinus syndrome. CVT severity scale correlated well with ICP, NIHSS, mRS and GCS. Patients with CVT severity scale > 10 can be defined as severe CVT. The CVT severity scale may serve as a valid and reliable tool for measuring the overall severity of CVT.

show abstract

“…CVST results in venous hypertension and the resultant cerebral edema can cause a range of symptoms such as nausea, vomiting, headache, seizures, and focal neurologic deficits [4,5,9]. These symptoms are highly non-specific and are usually attributed to the underlying brain tumor; this is the reason why many reports estimated an approximate 7-day delay between the onset of symptoms and the diagnosis [9]. CVST can potentially lead to serious complications.…”

Section: Discussionmentioning

confidence: 99%

“…CVST can potentially lead to serious complications. About 50% of patients with CVST develop infarction and/or hemorrhage [9]. The underlying venous hypertension was thought to be the main driver causing reduced effective drainage of affected brain tissue resulting in venous congestion with subsequent oxygen debt and eventual infarction.…”

Section: Discussionmentioning

confidence: 99%

Cerebral venous sinus thrombosis with venous hemorrhagic infarct in a patient with high-grade glioma of the left thalamus

Thatikonda¹,

Pathak²

2021

IJCR

View full text Add to dashboard Cite

Cerebral venous sinus thrombosis (CVST) is an uncommon type of venous thromboembolism whose diagnosis is often difficult due to its vague and non-specific clinical findings. Sometimes, the diagnosis is delayed as the symptoms were considered to be attributable to the underlying etiology, especially in patients with brain tumors such as high-grade glioma (HGG). We described the case of a 60-yearold male patient who presented with headache, generalized seizures, and right hemiparesis soon after receiving brain radiation and temozolomide therapy for HGG of the left thalamus. Initially, his symptoms were considered to be due to his underlying tumor but the subsequent imaging revealed left transverse, left sigmoid, and superior sagittal sinus thrombosis with venous hemorrhagic infarct of the left occipitoparietal lobe. The patient was started on anticoagulant therapy and symptoms resolved completely within a month. Clinicians should always consider CVST in the differential diagnosis of non-specific neurological symptoms, especially in patients with underlying brain tumors.

show abstract

Cerebral venous thrombosis: report of 2 cases of hemorrhagic venous infarction

Cited by 5 publications

References 13 publications

MRI ischemic and hemorrhagic lesions in arterial and venous territories characterize central nervous system intravascular lymphoma in dogs

MRI ischemic and hemorrhagic lesions in arterial and venous territories characterize central nervous system intravascular lymphoma in dogs

Development and validation of a severity scale based on clinical manifestations for patients with cerebral venous thrombosis

Cerebral venous sinus thrombosis with venous hemorrhagic infarct in a patient with high-grade glioma of the left thalamus

Contact Info

Product

Resources

About