Cerebral Venous Thrombosis With Topical Estrogen-Progesterone Use in a Young Heterosexual Male

Aldraihem, Moneera O.; Al-Senani, Fahmi; Bashir, Shahid

doi:10.1097/nrl.0000000000000455

Cited by 3 publications

(1 citation statement)

References 9 publications

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“…A 2023 case report by Aldraihem et al. showed extensive cerebral venous thrombosis in the right internal jugular vein, sigmoid, transverse, and straight cerebral venous and the application of crushed OCPs mixed with water topically on the scalp was found to be the most important predisposing factor 9 . In a meta‐analysis by Amoozegar et al., it was found that women taking OCPs had 7.59 times higher risk of developing CVST as compared to those not 10 .…”

Section: Discussionmentioning

confidence: 99%

Cerebral venous sinus thrombosis due to desogestrel intake in a young lady: A case report

Sharma,

Tewari,

Roy

et al. 2024

Clinical Case Reports

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Key Clinical MessageCerebral Venous Sinus Thrombosis (CVST) is a subtype of venous thromboembolism, which occurs in the dural venous sinuses. Blockage of the venous drainage of the brain leads to the development of hemorrhages. Strokes can hence develop in any individual, irrespective of age or sex. CVST is a very serious condition requiring immediate thrombolysis to prevent residual neurological deficits. We report the case of a lady aged 25 years, who presented to the emergency department with a severe diffuse headache for 4 days, associated with vomiting. This was followed by multiple episodes of seizures and altered sensorium the previous day. She had been taking desogestrel for the past 2 months. On examination, the patient was unconscious and febrile (102.8 F). On admission, Glasgow Coma Scale score of E2V2M3 and bilateral extensor plantar response were noted. Signs of meningeal irritation were absent. Her pupils were mid‐dilated, sluggishly reactive to light, and papilledema was present bilaterally. Based on imaging studies, she was diagnosed with a case of CVST. Her homocysteine levels were elevated. She recovered on appropriate treatment and was discharged on Ryle's feeding tube after 26 days of hospital stay with a Glasgow Coma Scale score of E4V5M6 and a flexor plantar response. The case emphasizes the need to rule out CVST in young adult females on oral contraceptive pills (OCP) presenting with severe neurological dysfunction. Vigilant screening, clinical suspicion and timely management can help cut down the associated mortality and morbidity in such cases.

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Section: Discussionmentioning

confidence: 99%

Cerebral venous sinus thrombosis due to desogestrel intake in a young lady: A case report

Sharma,

Tewari,

Roy

et al. 2024

Clinical Case Reports

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Ethinylestradiol/cyproterone misuse

2022

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Intracranial venous sinus thrombosis: Medical and surgical management considerations

Kharbat¹,

Michel²,

Morgan³

et al. 2023

BIJNN

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Cerebral venous thrombosis is a serious neurological condition characterized by thrombus formation in the venous sinuses or cerebral veins. Although rare, it is a potentially fatal condition that requires prompt diagnosis and treatment. This review aims to present the most current trends in our understanding of CVT risk factors, diagnosis, medical management, role of endovascular management, risk of intracranial hemorrhage, and emerging therapies. Most cases of CVT are diagnosed by clinical features and neuroimaging suggestive of sinus occlusion. While anticoagulation with heparin is the mainstay of medical management, direct-oral anticoagulants are emerging as a potential alternative, and severe cases have been managed successfully with thrombectomy and/or intrasinus urokinase thrombolysis. Despite recent advances in anticoagulation therapy and diagnostics, larger randomized studies are required to adequately assess these emerging therapies and better inform the management of patients suffering from CVT.

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Cerebral Venous Thrombosis With Topical Estrogen-Progesterone Use in a Young Heterosexual Male

Cited by 3 publications

References 9 publications

Cerebral venous sinus thrombosis due to desogestrel intake in a young lady: A case report

Cerebral venous sinus thrombosis due to desogestrel intake in a young lady: A case report

Ethinylestradiol/cyproterone misuse

Intracranial venous sinus thrombosis: Medical and surgical management considerations

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