“…Neuroimaging studies in survivors of pediatric brain tumor have found reduced white matter integrity in specific tracts ( Aukema et al, 2009 ; King et al, 2015b ; Mabbott et al, 2006 ; Palmer et al, 2012 ; Riggs et al, 2014 ; Rueckriegel et al, 2010 ; Smith et al, 2014 ) and that the integrity of these tracts is associated with performance on neurocognitive measures of processing speed, motor speed, full scale IQ, fine motor function, working memory, memory, and executive functioning ( Aukema et al, 2009 ; Brinkman et al, 2012 ; Law et al, 2011 ; Palmer et al, 2012 ; Riggs et al, 2014 ; Rueckriegel et al, 2015 ). These studies suggest that structural changes to white matter may represent the neurobiological underpinnings of outcomes.…”