“…2 The abnormality is thought to be caused by somatic mutations occurring prior to the migration of neural crest cells, which can lead to various venous abnormalities along the facial, osseous and cerebral planes which follow a segmental or 'metameric' distribution. 3 CVMS is classified into three groups: medial prosencephalic (olfactory) which involve the forehead, nose, corpus callosum, hypothalamus and hypophysis (CVMS 1); lateral prosencephalic (optic) which involve the temporo-parietaloccipital lobes, retina, optic nerve, eye, thalamus, maxilla and cheek (CVMS 2) and rhombencephalic/mesencephalon (otic) which affect the cerebellum, brainstem, lower face, mandible, petrous bone, and maxilla (CVMS 3). 4…”