Cerebroplacental doppler ratio and perinatal outcome in late-onset foetal growth restriction

Kahramanoğlu, Özge; Demirci, Oya; Özdemir, Mucize Eriç; Rapisarda, Agnese Maria Chiara; Akalın, Münip; Odacilar, Ali Sahap; İsmailov, Hayal; Dizdaroğulları, Gizem Elif; Öçal, Aydın

doi:10.1080/01443615.2021.1954148

Cited by 5 publications

(3 citation statements)

References 36 publications

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“…First, the CPR was a predictor of APOs in fetuses with late-onset FGR. 25 However, all of the fetuses in our study had normal UA resistance indices including CPR, UA-PI and MCA-PI values, which indicated to some extent that the fetus was not seriously compromised. Furthermore, the timing for delivering SGA fetuses was at 37 weeks of gestation rather than terminating the pregnancy unless the fetus was severely damaged.…”

Section: Discussionmentioning

confidence: 57%

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Prediction of late-onset fetal growth restriction by umbilical artery velocities at 37 weeks of gestation: a cross-sectional study

et al. 2022

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ObjectiveTo explore the predictive capacity of umbilical artery (UA) velocities at 37 weeks of gestation in identifying fetal growth restriction (FGR).DesignCross-sectional study.Setting and participantsWe retrospectively recruited 569 fetuses in the study. Thirty-nine FGR infants and 57 small-for-gestational-age (SGA) infants with normal UA Doppler at 37 weeks, as the study groups and 473 adequate-for-gestational-age (AGA) infants as a control group in a tertiary referral centre.MethodsAll the parameters of UA velocities, including the UA end-diastolic velocity (UA-EDV), UA peak systolic velocity (UA-PSV), UA mean diastolic velocity (UA-MDV) and UA time-averaged maximum velocity (UA-TAMXV), and UA Doppler were measured at approximately 37 weeks of gestation.ResultsAmong the FGR, SGA and AGA groups, the UA-MDV, UA-TAMXV, UA-PSV and UA-EDV decreased with the loss of fetal weight. Multivariate logistic regression analyses showed that the UA-TAMXV was an independent predicting factor of FGR. It had a moderate predictive value for FGR. The area under the receiver operating characteristic curve was 0.82 (95% CI: 0.79 to 0.85).ConclusionsThe UA velocities decreased with the loss of fetal weight among the FGR, SGA and AGA groups and the UA-TAMXV was independently predictive of FGR. The results suggest that the UA-TAMXV might be a new parameter to predict FGR prior to delivery.

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Section: Discussionmentioning

confidence: 57%

“…The possible reasons might be as follows. First, the CPR was a predictor of APOs in fetuses with late-onset FGR 25. However, all of the fetuses in our study had normal UA resistance indices including CPR, UA-PI and MCA-PI values, which indicated to some extent that the fetus was not seriously compromised.…”

Section: Discussionmentioning

confidence: 59%

Prediction of late-onset fetal growth restriction by umbilical artery velocities at 37 weeks of gestation: a cross-sectional study

et al. 2022

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“…It is worth noting that some recent studies have focused on the efficacy of Doppler ultrasound calculation of the CPR for the effective diagnosis of FGR, but the research results are controversial [6,13,16]. A Study by Ozge et al [17], calculated the ratio of the PI values of UA and MCA to obtain CPR, suggesting that CPR may help identify adverse perinatal outcomes in fetuses with FGR. Additionally, according to a recent research, offspring born to patients of FGR with a CPR<1 have a significantly increased risk of delayed neurodevelopment at the age of 3 years [18].…”

Section: Discussionmentioning

confidence: 99%

Comparison and Analysis of Cerebroplacental Ratio and Umbilicocerebral Ratio in the Prenatal Diagnosis and Severity Assessment of Fetal Growth Restriction: A Retrospective Study and Systematic Review

Zheng,

Zhao,

Mao

et al. 2024

Arch Obstet Gynecol

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Purpose: Doppler flow parameters of fetal umbilical artery (UA) and middle cerebral artery (MCA) have been widely used for fetal growth restriction (FGR), but their diagnostic efficacy remains contentious. The purpose of this study is to clarify the superiority of cerebroplacental ratio (CPR) and umbilicocerebral ratio (UCR) in terms of their correlation and predictive accuracy in diagnosing FGR. Methods: Doppler flow parameters of the UA and MCA were tested for FGR patients and normal pregnant women during the third trimester. Collection of delivery gestational weeks and neonatal birth weight were conducted. Logistic regression and area under the curve (AUC) analysis were used to elucidate the association and diagnostic accuracy of CPR and UCR for diagnosing FGR. Results: The CPR-EDV and CPR-MFV in FGR patients were higher, while the CPR-S/D, CPR-PI, and CPR-RI were lower (P<0.05). The UCR-EDV in the FGR group was lower than that in the NC group, while the UCR-S/D and UCR-PI were higher than those in the NC group (P<0.05). Only the CPR-PI (OR:0.166, 95% CI 0.049 ~ 0.563, P = 0.004) was independently associated with FGR. A positive correlation between CPR-PI and delivery gestational weeks was found, as well as neonatal birth weight. The AUC of CPR-PI for detecting FGR was 0.719 (95% CI 0.594 ~ 0.844; P=0.003), with a critical value of 1.57. Conclusion: Compared with UCR and simple UA or MCA blood flow parameters, CPR-PI may be the most optimized ultrasound parameter for diagnosing and assessing FGR.

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Inflammatory markers as predictors of late-onset fetal growth restriction: a focus on neutrophil-to-lymphocyte and platelet-to- lymphocyte ratios

Kahramanoğlu,

Gök

2024

Turkish Journal of Clinics and Laboratory

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Aim: This study evaluates the role of hematologic inflammatory markers, specifically neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR), in predicting late-onset fetal growth restriction (FGR). Material and Methods: A retrospective comparative analysis was conducted on 76 pregnancies complicated by late- onset FGR and 100 healthy pregnancies as controls. Maternal blood samples were collected, and hematologic parameters, including NLR and PLR, were recorded. Data analysis compared inflammatory markers between the FGR and control groups to assess the relationship between maternal inflammatory profiles and FGR. Results: NLR was significantly higher in the FGR group compared to the control group (p

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Cerebroplacental doppler ratio and perinatal outcome in late-onset foetal growth restriction

Cited by 5 publications

References 36 publications

Prediction of late-onset fetal growth restriction by umbilical artery velocities at 37 weeks of gestation: a cross-sectional study

Prediction of late-onset fetal growth restriction by umbilical artery velocities at 37 weeks of gestation: a cross-sectional study

Comparison and Analysis of Cerebroplacental Ratio and Umbilicocerebral Ratio in the Prenatal Diagnosis and Severity Assessment of Fetal Growth Restriction: A Retrospective Study and Systematic Review

Inflammatory markers as predictors of late-onset fetal growth restriction: a focus on neutrophil-to-lymphocyte and platelet-to- lymphocyte ratios

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