2015
DOI: 10.1186/s13195-015-0114-5
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Cerebrospinal fluid amyloid-β 42/40 ratio in clinical setting of memory centers: a multicentric study

Abstract: IntroductionThe cerebrospinal fluid (CSF) biomarkers amyloid-β (Aβ), tau and phosphorylated tau (p-tau181) are now used for the diagnosis of Alzheimer’s disease (AD). Aβ40 is the most abundant Aβ peptide isoform in the CSF, and the Aβ 42/40 ratio has been proposed to better reflect brain amyloid production. However, its additional value in the clinical setting remains uncertain.MethodsA total of 367 subjects with cognitive disorders who underwent a lumbar puncture were prospectively included at three French me… Show more

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Cited by 120 publications
(101 citation statements)
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“…In line with a number of previous reports [1719], but in contrast to others [8, 9, 34, 35], approximately half of the MCI cases in our study had conflicting CSF biomarker constellations. This discrepancy in the frequency of patients with conflicting CSF biomarker results could be possibly attributed to differences in study design.…”
Section: Discussionsupporting
confidence: 89%
See 1 more Smart Citation
“…In line with a number of previous reports [1719], but in contrast to others [8, 9, 34, 35], approximately half of the MCI cases in our study had conflicting CSF biomarker constellations. This discrepancy in the frequency of patients with conflicting CSF biomarker results could be possibly attributed to differences in study design.…”
Section: Discussionsupporting
confidence: 89%
“…A further shortcoming of the study is the collection of some early CSF samples into inappropriate tubes at the ADNI sites. Although the error was corrected rapidly and despite the relatively limited exposure time to any inappropriate CSF collection tube, this error could embody a source of bias because the use of different collection tubes increases intra-laboratory variability [34, 5658]. Moreover, we did not take into account imaging biomarker data.…”
Section: Discussionmentioning
confidence: 99%
“…However, the Aβ42/Aβ40 ratio was significantly higher in EVs compared to the fluids from which they were isolated. These findings are of interest with regards to AD pathogenesis as the Aβ42/Aβ40 ratio has been found to be a more reliable biomarker for AD than Aβ42 or Aβ40 alone 44 . Moreover, mixtures of Aβ42 and Aβ40 with a higher Aβ42/Aβ40 ratio aggregate more vigorously and are more neurotoxic than mixtures with a low Aβ42/Aβ40 ratio 45,46 .…”
Section: Discussionmentioning
confidence: 84%
“…The ac magnetic signal from the sample is detected by the pick-up coil and is transmitted to the flux coupling component.
Fig. 3Configuration of the single-channel high-Tc SQUID ac magnetosusceptometer for IMR measurement [44]
…”
Section: Methods Used In Original Studiesmentioning
confidence: 99%