Cerebrospinal fluid chitinase‐3‐like 2 and chitotriosidase are potential prognostic biomarkers in early multiple sclerosis

Møllgaard, Maja Vedel; Degn, Matilda; Sellebjerg, Finn; Frederiksen, Jette Lautrup; Modvig, Signe

doi:10.1111/ene.12960

Cited by 57 publications

(47 citation statements)

References 31 publications

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“…24 Elevations in CHIT1 have also been observed in lysosomal storage diseases 25 and multiple sclerosis, 26 whereas increased CSF CHI3L1 level is associated with progression to multiple sclerosis following a clinically isolated syndrome. 24 Elevations in CHIT1 have also been observed in lysosomal storage diseases 25 and multiple sclerosis, 26 whereas increased CSF CHI3L1 level is associated with progression to multiple sclerosis following a clinically isolated syndrome.…”

Section: Discussionmentioning

confidence: 99%

Cerebrospinal fluid macrophage biomarkers in amyotrophic lateral sclerosis

Thompson

Thézénas

et al. 2018

Annals of Neurology

116

100

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Section: Discussionmentioning

confidence: 99%

Cerebrospinal fluid macrophage biomarkers in amyotrophic lateral sclerosis

Thompson

Thézénas

et al. 2018

Annals of Neurology

116

100

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“…Chitinases predict prognosis in early MS. The most recent evidence indicates that CHI3L2 performs better than CHI3L1 and predicts the development of MS after the first demyelinating episode, 98 although in the earlier work, CHI3L1 was mostly studied and a similar predictive capability was demonstrated. 99 Consistency of findings.…”

Section: Neurofilamentsmentioning

confidence: 99%

Science is 1% inspiration and 99% biomarkers

et al. 2017

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Neurodegeneration plays a key role in multiple sclerosis (MS) contributing to long-term disability in patients. The prognosis is, however, unpredictable coloured by complex disease mechanisms which can only be clearly appreciated using biomarkers specific to pathobiology of the underlying process. Here, we describe six promising neurodegenerative biomarkers in MS (neurofilament proteins, neurofilament antibodies, tau, N-acetylaspartate, chitinase and chitinase-like proteins and osteopontin), critically evaluating the evidence using a modified Bradford Hill criteria.

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“…In the human brain, ChT is proposed to be synthesized by microglia and high CSF ChT levels have been shown in several neurological conditions [14][15][16]. Previous reports revealed that ChT is increased in CSF in patients with ALS and proposed this enzyme as a potential biomarker for ALS [17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Chitotriosidase and CC-Chemokine Ligand 18 as Biomarkers of Microglia Activation in Amyotrophic Lateral Sclerosis

et al. 2018

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Background: The development of biomarkers for use in diagnosing, monitoring disease progression and analyzing therapeutic trials response in amyotrophic lateral sclerosis (ALS) is essential. Objective: The aim of this study was to identify inflammatory factors in plasma or cerebrospinal fluid (CSF) from patients with ALS with particular attention to specific markers of microglia activation as chitotriosidase (ChT) and chemokine (C-C motif) ligand 18 (CCL18) to determine its potential as ALS biomarkers. Methods: We studied CSF and plasma samples from 32 patients and 42 healthy controls. We assayed the ChT activity by a spectrofluorometric method and protein levels of other inflammatory biomarkers (tumor necrosis factor [TNF]-alpha, interleukin [IL]-6 and CCL18) by enzyme-linked immunosorbent assay. CHIT1 gene polymorphism in exon 10 (c.1049_1072dup24) encoding inactive ChT enzyme was genotyped in all subjects. Results: ChT activity and TNF-alpha protein levels were significantly higher in CSF of ALS patients, but we found no correlation with the severity and progression of the disease. Nevertheless, we did not found any differences in CCL18 or IL-6 protein levels between both groups in CSF or plasma. In our sample, only 3% of subjects were homozygous carriers for the CHIT1 exon 10 duplication associated with defective enzyme. Conclusions: High ChT activity in CSF of patients with ALS may reflect microglia activation and could be a potential biomarker of the disease. We did not find any significant difference regarding CCL-18, another specific marker of microglia activation that is related with M2-like microglia phenotype. Deepening the understanding of the activation state of microglia (M1 and M2) may contribute to the knowledge about the specific role of neuroinflammation in ALS and future therapeutic strategies.

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Cerebrospinal fluid chitinase‐3‐like 2 and chitotriosidase are potential prognostic biomarkers in early multiple sclerosis

Abstract: CHI3L2 and chitotriosidase are promising biomarkers in patients with a first demyelinating episode. Our findings thus support a role for these proteins as biomarkers in early MS.

Cited by 57 publications

References 31 publications

Cerebrospinal fluid macrophage biomarkers in amyotrophic lateral sclerosis

Cerebrospinal fluid macrophage biomarkers in amyotrophic lateral sclerosis

Science is 1% inspiration and 99% biomarkers

Evaluation of Chitotriosidase and CC-Chemokine Ligand 18 as Biomarkers of Microglia Activation in Amyotrophic Lateral Sclerosis

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