Cerebrospinal Fluid Creatine Kinase–BB Isoenzyme Activity and Outcome After Subarachnoid Hemorrhage

Abstract

The level of CSF CK-BB may help predict neurologic outcome after SAH.

Biomarkers as outcome predictors in subarachnoid hemorrhage – a systematic review

“…In SAH, acceptable sensitivities and specificities were demonstrated with CRP, selectin, thrombin antithrombin complex (TAT), creatine kinase-BB (CK-BB) and malondialdehyde (MDA) (83 versus 84%, 90 versus 83%, 72 versus 70%, 70 versus 100% and 88 versus 75%, respectively) (Coplin et al, 1999; Jeon et al, 2012; Kaneda et al, 2010; Morga et al, 2007; Wang et al, 2011). Although most of the sensitivities and specificities are not greater than 90%, each of these markers may be able to identify subjects that have poor outcome and those that will potentially recover well with some reasonableness.…”

“…CK-BB is a creatine kinase found in the brain and is involved in energy maintenance within mitochondria. Coplin et al (1999) demonstrated that increased CSF levels of CK-BB, greater than 40 U/L, was associated with unfavorable outcome at 1 week and 2 months after SAH.…”

Cerebrospinal creatinine kinase level in children with meningitis

“…In the work of Coplin et al [12], in which a cutoff value of 40 U/L was used for CK-BB level, the sensitivity and specificity of 70% and 100% were determined respectively for subarachnoid hemorrhage in general. However, Briem H et al [13], have indicated that the determination of the CK-BB activity in the CSF is not useful in differentiating diagnosis but in only the prognosis of bacterial and viral meningitis.…”

Biomarcadores prognósticos no traumatismo crânio-encefálico grave

“…The brain has many isoforms CKBB and mitochondrial-CK but lacks CKMB and CKMM, respectively found in the cardiac and skeletal muscles. (34) The molecular mass of CKBB is 40 to 53 kDa. (16) CK-BB is located in the astrocytes and is released when there is anatomical injury in the brain tissue.…”

“…(16) Various situations of brain injury such as cardiac arrest and subarachnoid hemorrhage may lead to release of CKBB in the liquor. (34) High CKBB serum levels are also found in adenocarcinomas of the prostate, breast, ovary, colon, other adenocarcinomas of the gastrointestinal tract and also in small cell anaplastic carcinoma of the lungs. (35) Severe TBI studies have disclosed correlation of the severity score assessed by GCS with serum levels of CKBB.…”