Cerebrospinal fluid flow on time‐spatial labeling inversion pulse images before and after treatment of congenital hydrocephalus in a dog

Ito, Daisuke; Ishikawa, Chieko; Jeffery, Nick; Kitagawa, Masato

doi:10.1111/jvim.16020

Cited by 4 publications

(1 citation statement)

References 41 publications

(125 reference statements)

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“…In our unbiased assortation of chromosome numbers in ten species, we found, as expected, that primates (orangutans) have chromosome numbers consistent with those of humans. However, dogs, a species commonly used for neurosurgical studies ( Dombrowski et al, 2006 ; Park et al, 2010 ; Gomes et al, 2020b ; a ; Hasegawa, 2020 ; Olszewska et al, 2020 ; Ito et al, 2021 ; Lee et al, 2021 ), have significantly more chromosomes (78), suggesting reconsiderations regarding the appropriateness of the canine model for certain genetic studies.…”

Section: Discussionmentioning

confidence: 99%

TRPV4 mRNA is elevated in the caudate nucleus with NPH but not in Alzheimer’s disease

et al. 2022

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Symptoms of normal pressure hydrocephalus (NPH) and Alzheimer’s disease (AD) are somewhat similar, and it is common to misdiagnose these two conditions. Although there are fluid markers detectable in humans with NPH and AD, determining which biomarker is optimal in representing genetic characteristics consistent throughout species is poorly understood. Here, we hypothesize that NPH can be differentiated from AD with mRNA biomarkers of unvaried proximity to telomeres. We examined human caudate nucleus tissue samples for the expression of transient receptor potential cation channel subfamily V member 4 (TRPV4) and amyloid precursor protein (APP). Using the genome data viewer, we analyzed the mutability of TRPV4 and other genes in mice, rats, and humans through matching nucleotides of six genes of interest and one house keeping gene with two factors associated with high mutation rate: 1) proximity to telomeres or 2) high adenine and thymine (A + T) content. We found that TRPV4 and microtubule associated protein tau (MAPT) mRNA were elevated in NPH. In AD, mRNA expression of TRPV4 was unaltered unlike APP and other genes. In mice, rats, and humans, the nucleotide size of TRPV4 did not vary, while in other genes, the sizes were inconsistent. Proximity to telomeres in TRPV4 was <50 Mb across species. Our analyses reveal that TRPV4 gene size and mutability are conserved across three species, suggesting that TRPV4 can be a potential link in the pathophysiology of chronic hydrocephalus in aged humans (>65 years) and laboratory rodents at comparable ages.

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Section: Discussionmentioning

confidence: 99%

TRPV4 mRNA is elevated in the caudate nucleus with NPH but not in Alzheimer’s disease

et al. 2022

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Cerebrospinal fluid flow on time‐spatial labeling inversion pulse images before and after treatment of congenital hydrocephalus in a dog

Ito

Ishikawa

Jeffery

et al. 2021

Veterinary Internal Medicne

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A 3-month-old male crossbreed dog presented with signs of progressive diffuse brain disease. Noncommunicating congenital hydrocephalus concurrent with cervical syringomyelia was diagnosed on magnetic resonance images. On time-spatial labeling inversion pulse (Time-SLIP) images CSF flow through the mesencephalic aqueduct was poorly defined and there was flow into the syrinx across the craniocervical junction. After percutaneous ventricular drainage and ventriculoperitoneal shunting, CSF flow through the aqueduct was clearly detected and flow into the syrinx disappeared.

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Cerebrospinal fluid flow in small-breed dogs with idiopathic epilepsy observed using time-spatial labeling inversion pulse images: a preliminary study

ISHIKAWA,

TANAKA,

SEKIGUCHI

et al. 2024

J. Vet. Med. Sci.

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Cerebrospinal fluid (CSF) circulation diseases, such as hydrocephalus and syringomyelia, are common in small-breed dogs. In human patients with CSF circulation diseases, time-spatial labeling inversion pulse (time-SLIP) sequence performed to evaluate CSF flow before and after treatment allows visualization of the restoration of CSF movement. However, studies evaluating CSF flow using the time-SLIP method in small-breed dogs are limited. Therefore, the present study aimed to evaluate intracranial CSF flow on time-SLIP images in small-breed dogs with idiopathic epilepsy, as an alternative model to healthy dogs. Time-SLIP images were obtained at two sites: 1) the mesencephalic aqueduct (MA) area (third ventricle, MA, and brain-base subarachnoid space [SAS]) and 2) the craniocervical junction area (fourth ventricle, brainstem, and cervical spinal cord SAS) to allow subsequent evaluation of the rostral and caudal CSF flow using subjective and objective methods. In total, six dogs were included. Caudal flow at the MA and brain-base SAS and rostral flow in the brainstem SAS were subjectively and objectively observed in all and 5/6 dogs, respectively. Objective evaluation revealed that a significantly smaller movement of the CSF, assessed as the absence of CSF flow by subjective evaluation, could be detected in some areas. In small-breed dogs, the MA, brain-base, and brainstem SAS would be appropriate areas for evaluating CSF movement, either in the rostral or caudal flows on time-SLIP images. In areas where CSF movement cannot detected by subjective methods, an objective evaluation should be conducted.

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Cerebrospinal fluid flow on time‐spatial labeling inversion pulse images before and after treatment of congenital hydrocephalus in a dog

Cited by 4 publications

References 41 publications

TRPV4 mRNA is elevated in the caudate nucleus with NPH but not in Alzheimer’s disease

TRPV4 mRNA is elevated in the caudate nucleus with NPH but not in Alzheimer’s disease

Cerebrospinal fluid flow on time‐spatial labeling inversion pulse images before and after treatment of congenital hydrocephalus in a dog

Cerebrospinal fluid flow in small-breed dogs with idiopathic epilepsy observed using time-spatial labeling inversion pulse images: a preliminary study

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