Cerebrospinal fluid folate and cobalamin levels in febrile convulsion

Osifo, Bola O.A.; Lukanmbi, F.A.; Familusi, J. B.

doi:10.1016/0022-510x(85)90099-1

Cited by 4 publications

(4 citation statements)

References 10 publications

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“…Osifo et al [20] found that serum vitamin B12 levels were lower in patients with FC compared to healthy group and febrile group without seizures. Vitamin B12 levels were significantly lower in our study group compared to the control group, which suggests that low vitamin B12 levels may act a part in the etiopathogenesis of FC.…”

Section: Discussionmentioning

confidence: 97%

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Comparison of laboratory parameters between children with and without febrile convulsion

Aydin¹,

Bucak²

2021

Journal of Surgery and Medicine

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Background/Aim: Febrile convulsion is the most common central nervous system disease of childhood. The etiology of febrile convulsion is not fully brightened. In this study, we aimed to evaluate the relationship between hemogram, biochemical and hormonal parameters and febrile convulsion, and the roles of laboratory parameters in its etiopathogenesis. Methods: A total of fifty-four patients diagnosed with febrile convulsion in the pediatric neurology outpatient clinic of a tertiary hospital from October 2017 to December 2018 were included in this retrospective cohort study. Age, sex, age of first convulsion, type of convulsion and laboratory parameters of the patients were recorded. ILAE classification system was used for the diagnosis of febrile convulsion. Febrile convulsion patients were included in the study group, while the control group was randomly selected from patients between 6 months and 6 years of age who visited general pediatric outpatient clinic. Results: A total of 54 patients (30 males, 24 females) in the study group and 82 patients (53 males, 29 females) in the control group were included in the study (P=0.288). The mean ages of the patients in the study and control groups were 30.31 (14.64) months and 32.32 (19.70) months, respectively (P=0.524). Mean platelet volume (MPV), platelet count, 25-OH D3, vitamin B12 and phosphorus values were significantly lower in the study group (P<0.001, P=0.013, P=0.017, P=0.020). Conclusion: MPV, platelet count, 25 OH D3, vitamin B12 lower levels may be risk factors for febrile convulsion. Studies related to the etiopathogenesis of febrile convulsion are necessary to enlighten the subject and laboratory results will be the guide in this sense.

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Section: Discussionmentioning

confidence: 97%

“…Osifo et al [20] investigated the relationship among serum folic acid values and seizure formation in thirty-two febrile children aged 8 months to 5 years. The authors reported that serum folic acid values in children with FC were significantly higher than those in seizure-free children.…”

Section: Discussionmentioning

confidence: 99%

Comparison of laboratory parameters between children with and without febrile convulsion

Aydin¹,

Bucak²

2021

Journal of Surgery and Medicine

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“…Although it is thought that low vitamin B12 may be a factor triggering seizures, its mechanism of action is still unclear [ 50 , 51 ]. Few studies determined the relationship between vitamin B12 deficiency and febrile seizures in children.…”

Section: Discussionmentioning

confidence: 99%

“…Few studies determined the relationship between vitamin B12 deficiency and febrile seizures in children. Osifo et al [ 50 ] found that the levels of vitamin B12 were significantly higher in children with febrile seizures compared to children with FS, but there were no significant differences in vitamin B12 levels in the cerebrospinal fluid. Biancheri et al [ 44 ] determined EEG abnormalities in all children.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Serum Selenium, Homocysteine, Zinc, and Vitamin D Levels in Febrile Children with and without Febrile Seizures: A Prospective Single-Center Study

Çiğri

İnan

2023

Children

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Objective: Febrile seizure is a complication that makes physicians and families uneasy when detected in children with a high fevers. This study aimed to compare children with febrile seizures and children without seizures in blood selenium, zinc, homocysteine, vitamin D, vitamin B12, and magnesium levels. Materials and Methods: The study group included sixty-one children between the ages of 1–5 who came to the pediatric emergency department with febrile seizure. The control group had 61 children with fever without seizure, who were compatible with the study group in age, sex, and elapsed time since the onset of fever. Blood samples were taken from the patients during their admission. Selenium, zinc, vitamin D, homocysteine, vitamin B12, and magnesium levels were measured, and the data of the two groups were compared. Additionally, patients in the study group had two subgroups, simple and complex febrile seizures, and their parameters were compared. Results: Selenium, zinc, vitamin D, and vitamin B12 levels were significantly lower in the study group than in the control group (p < 0.001), and there was no significant difference in homocysteine (p = 0.990) and magnesium levels (p = 0.787) between the two groups. Moreover, no significant difference was found between those with simple and complex febrile seizures in selenium, vitamin D, homocysteine, vitamin B12, and magnesium levels. Conclusions: Elevated levels of selenium, zinc, vitamin D, and vitamin B12 in the blood of children with fevers help to prevent febrile seizures.

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Concentrations of the water-soluble vitamins thiamin, ascorbic acid, and folic acid in serum and cerebrospinal fluid of healthy individuals

Tallaksen

Bøhmer

Bell

1992

The American Journal of Clinical Nutrition

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Thiamin, thiamin monophosphate, ascorbic acid, and folic acid were determined in serum and cerebrospinal fluid (CSF) in 31 outpatients who underwent a myelography because of back-pain. All subjects were otherwise healthy. The CSF concentration (mean +/- SD) was 8.6 +/- 3.9 nmol thiamin/L, 16.9 +/- 8.3 nmol thiamin monophosphate/L, 133 +/- 58.8 mumol ascorbic acid/L, and 44.9 +/- 13.2 nmol folic acid/L. The CSF-serum ratio was 2.1 +/- 0.8 for thiamin, 8.3 +/- 4.3 for thiamin monophosphate, 3.0 +/- 1.4 for ascorbic acid, and 3.3 +/- 0.8 for folic acid; the amount in CSF was significantly higher than in serum for each compound. These results support the existence of a saturated transport mechanism of water-soluble vitamins from serum into CSF for thiamin monophosphate, ascorbic acid, and folic acid. However, low CSF concentrations are correlated with low serum concentrations for the three vitamins. High serum concentrations should therefore be advocated to ensure high CSF concentrations.

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Cerebrospinal fluid folate and cobalamin levels in febrile convulsion

Cited by 4 publications

References 10 publications

Comparison of laboratory parameters between children with and without febrile convulsion

Comparison of laboratory parameters between children with and without febrile convulsion

Comparison of Serum Selenium, Homocysteine, Zinc, and Vitamin D Levels in Febrile Children with and without Febrile Seizures: A Prospective Single-Center Study

Concentrations of the water-soluble vitamins thiamin, ascorbic acid, and folic acid in serum and cerebrospinal fluid of healthy individuals

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