Cerebrospinal Fluid Glutamate Levels in Chronic Migraine

Peres, Mario F. P.; Zukerman, Eliova; Soares, Carlos Augusto Senne; Alonso, Elena O.; Santos, Bento Fortunato Cardoso dos; Faulhaber, Markus

doi:10.1111/j.1468-2982.2004.00750.x

Cited by 110 publications

(112 citation statements)

References 27 publications

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“…We have recently shown that chronic migraine is related to a hyperglutamatergic state in the brain, confirmed by higher cerebrospinal fluid glutamate levels in chronic migraineurs compared to controls [10]. Therefore, topiramate may be a candidate for chronic migraine prevention.…”

Section: Discussionmentioning

confidence: 95%

Chronic migraine prevention with topiramate

et al. 2006

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Chronic migraine (CM) is a disabling condition with not many treatment strategies available. Topiramate is effective in episodic migraine prevention, however little is known about its effect in CM. An open label study was performed. Sixty-four patients diagnosed with CM or probable CM according to the IHS diagnostic criteria were enrolled, 50 patients were available for analysis and an intention-to-treat methodology was applied. The primary endpoint considered was the number of patients with a decrease in headache frequency higher than 50%. The median dose was 100 mg, a reduction in frequency higher than 50% occurred in 33 patients (66%) and 14 (28%) presented a complete response, defined as a frequency reduction higher than 95%. The medication was well tolerated. The most common side effects found were weight loss, paraesthesias, nausea, cognitive dysfunction, fatigue, somnolence, insomnia and depression. Our findings suggest that topiramate is effective in CM prophylaxis.

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Section: Discussionmentioning

confidence: 95%

Chronic migraine prevention with topiramate

et al. 2006

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“…Cognitive functions involve both brain regions (cortical and subcortical areas) 14 and several neurotransmitters such as dopamine and noradrenaline, important in verbal fluency, attention, working memory, learning, motivation and adaptive behavior, and glutamate, which also seems to play an important role in learning and memory [22][23][24][25][26] . It is believed that these neurotransmitters play an important role in the pathophysiology of migraine [27][28][29][30] . Accordingly, maybe neurochemical aspects involved in the physiopathology of migraine and cognition mechanisms may explain our findings.…”

Section: Discussionmentioning

confidence: 99%

Migraine and cognition in children: a controlled study

Moutran

Villa

Diaz

et al. 2011

Arq. Neuro-Psiquiatr.

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Objective: Evaluate the cognitive functions of children with migraine and compare them to A control group. Method: 30 migraineur children and 30 control group children without migraine, age ranging from 8 to 12 years old, were subjected to a cognitive functions assessment with Wechsler Intelligence Scale for Children (WISCIII). Results: Although both groups had a normal cognitive performance, children with migraine had significantly worse scores compared to the control group in the subtests of Information, Arithmetic, Vocabulary, Object Assembly and in the Indexes of Perceptual Organization, Resistance to Distraction and Processing Speed. Conclusion: Children with migraine had impairment in some cognitive functions such as attention, memory, information speed, and perceptual organization compared to the control group.

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“…Primarily the latter is hypothesised to contribute to chronic sensitisation of central neurons (i.e. in the nucleus trigeminus) (19)(20)(21)(22). It is believed that this process also occurs in other chronic pain disorders such as fibromyalgia, where increased CSF concentrations of NGF, BDNF and glutamate have been found (21).…”

Section: Discussionmentioning

confidence: 99%

Migraine biomarkers in cerebrospinal fluid: A systematic review and meta-analysis

et al. 2016

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Objective: To perform a meta-analysis of migraine biomarkers in cerebrospinal fluid (CSF) and of corresponding blood concentrations. Methods: We conducted a systematic search for studies that measured biochemical compounds in CSF of chronic or episodic migraineurs and non-headache controls. Subsequent searches retrieved studies with blood measurements of selected CSF biomarkers. If a compound was assessed in three or more studies, results were pooled in a meta-analysis with standardised mean differences (SMD) as effect measures. Results: Sixty-two compounds were measured in 40 CSF studies. Most important results include: increased glutamate (five studies, SMD 2.22, 95% CI: 1.30, 3.13), calcitonin gene-related peptide (CGRP) (three studies, SMD: 3.80, 95% CI: 3.19, 4.41) and nerve growth factor (NGF) (three studies, SMD: 6.47, 95% CI: 5.55, 7.39) in chronic migraine patients and decreased b-endorphin (b-EP) in both chronic (four studies, SMD: -1.37, 95% CI: -1.80, -0.94) and interictal episodic migraine patients (three studies, SMD: -1.12, 95% CI: -1.65, -0.58). In blood, glutamate (interictal) and CGRP (chronic, interictal and ictal) were increased and b-EP (chronic, interictal and ictal) was decreased. Conclusions: Glutamate, b-EP, CGRP and NGF concentrations are altered in CSF and, except for NGF, also in blood of migraineurs. Future research should focus on the pathophysiological roles of these compounds in migraine.

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Cerebrospinal Fluid Glutamate Levels in Chronic Migraine

Cited by 110 publications

References 27 publications

Chronic migraine prevention with topiramate

Chronic migraine prevention with topiramate

Migraine and cognition in children: a controlled study

Migraine biomarkers in cerebrospinal fluid: A systematic review and meta-analysis

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